Abstract:
In Diabetic syndrome, function of heart and liver are commonly affected, causing the worsening
of these patients and hence, additional drugs apart from diabetic treatment are given to these
patients. However, these drugs cause additional complication promoting many side effects. This
thesis is composed of determining the metabolic abnormalities in the diabetic patients with the
complications of hypertension and liver cirrhosis. In addition this study is furthered on diabetic
patients with hepatitis B or C. In all these patients, the association of most important blood
enzymes, such as (1) aspartate aminotransferase (AST) or, (2) Serum Oxaloacetate Transaminase
(SGOT), (3) alanine aminotransferase (ALT) or (4) Serum Glutamate Pyruvate Transaminase
(SGPT), (5) creatinine phosphokinase (CPK), (6) lactate dehydrogenase (LDH) and (7) alkaline
Phosphatase (ALP) are studied. Some of the most important metals such as iron, zinc, copper
and magnesium and their overall impact on oxidative stress are also determined. My hypothesis
in diabetic patients a complete picture of metabolic abnormalities could be obtained, if enzymes
conventionally with liver, and heart dysfunction, are studies, total protein, albumin, creatinine,
urea, uric acid, total cholesterol, and triglyceride levels are monitored; the role and anti oxidant
activity of magnesium, zinc, copper is studied. This study was conducted one diabetes mellitus,
hypertension, liver cirrhosis, diabetes with hypertension, diabetes with liver cirrhosis hepatitis B,
hepatitis C, diabetes with hepatitis B, and diabetes with hepatitis C,. The purpose of my study is
to see the changes in enzyme activities related to metabolism and the variation in metal contents
with particular reference to Fe, Cu, Zn and Mg including the ant oxidative activity in diabetic
patients with and without complications. This will assist the pharmacists to design a new
chemotherapeutic, drugs, and for the physicians, to treat the patients with different complications
effectively.
