PASTIC Dspace Repository

SCREENING OF SELECTED PLANTS FOR ANTIDIABETIC POTENTIAL

Show simple item record

dc.contributor.author MAHMOOD, AYESHA
dc.date.accessioned 2018-03-15T08:52:46Z
dc.date.accessioned 2020-04-15T00:03:59Z
dc.date.available 2020-04-15T00:03:59Z
dc.date.issued 2015
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/10548
dc.description.abstract In the present study, traditionally used antidiabetic plants (Cassia absus, Moringa oleifera, Dalbergia sissoo, Mangifera indica, Azadirachta indica, Syzygium cumini, Heliotropium strigosum, Momordica charantia and Fagonia indica) were collected from different areas of Punjab, Pakistan. Ethanolic and aqueous extracts of plants obtained through stirring (extraction technique) were evaluated for antioxidant activity (2, 2- diphenylpicrylhydrazyl), antidiabetic activities (in vitro alpha amylase inhibition assay) and phytochemical studies (total phenolic and flavonoid contents). Further, antidiabetic activities (antihyperglycemic & antihyperlipidemic) of three plants (Moringa oleifera, Fagonia indica and Heliotropium strigosum) were also evaluated through in vivo experiments. Although all plant extracts exhibited good antioxidant and antidiabetic (alpha amylase inhibition) activities. However, aqueous extracts were found to have better alpha amylase inhibition activities and higher phenolic acids than ethanolic extracts. Aqueous extract of Heliotropium strigosum exhibited maximum inhibition (58.6±0.03%) at 1ppm. Overall, both aqueous and ethanolic extracts of selected plants showed good antihyperglycemic and antihyperlipidemic activities in alloxan induced diabetic rabbits but Fagonia indica aqueous extract caused maximum reduction (75.36%) in blood glucose level of alloxan induced diabetic rabbits after 21 days of treatment. High performance liquid chromatography analysis evidenced the presence of phenolic acids in all plants extracts. The variation in yield, phytochemicals constituents and biological activities of most of the plant extracts, with respect to solvent and plant species were statistically significant. en_US
dc.description.sponsorship Higher Education Commission, Pakistan en_US
dc.language.iso en en_US
dc.publisher UNIVERSITY OF AGRICULTURE, FAISALABAD en_US
dc.subject Natural Sciences en_US
dc.title SCREENING OF SELECTED PLANTS FOR ANTIDIABETIC POTENTIAL en_US
dc.type Thesis en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account