Abstract:
Green silver nanoparticles were biosynthesized utilizing aqueous leaves extracts of Agave
americana, Mangifera indica and Mentha spicata plants due to presence of pre-eminent reducing
and stabilizing phytochemicals. These biocompatible nanostructures were purified, optimized
and characterized as mildly neutral, polycrystalline, monodispersed and thermally sensitive
compounds owing predominantly spherical shape and 30–150 nm diameter. Biological/
pharmacological analysis in comparison to crude ethanolic, methanolic, aqueous and acetone
leaves extracts evinced stupendous antibacterial activity against all pathogenic experimental
bacteria particularly E.coli and MRSA. Evaluated MIC values for AgNPs and crude leaves
extracts against experimental bacteria lies in the range of 40–320 μL. Green AgNPs remarkably
inhibited the growth of all test fungal mycelia while moderate fungal growth inhibition was
demonstrated by crude leaves extracts. Good anticancer activity was demonstrated by A.
americana AgNPs (69%) and acetone extracts (78%) while remaining AgNPs and extracts
moderately inhibited prostrate tumor proliferation. Robust antioxidant activity was demonstrated
by AgNPs and crude leaves extracts at highest sample concentration of 300 μL. In parallel,
significantly exalted cytotoxic, phytotoxic, anti-termite, insecticidal activity was exhibited by
bioinspired AgNPs and crude leaves extracts at highest sample concentration of 1000 μL.
Moderate enzyme inhibition was manifested against acetylcholine esterase and urease. Finally
absence of phyto-glutinins was evinced by negative hemagglutination reactions.
