Abstract:
The present study will report the synthesis of N-derivatives of 5-halogeno substituted
pyramiding 2,4-dione by conventional and solid state microwave assisted methods.
Derivitization of 5-halogenated pyrimidine, 2, 4 dione give predominately N1and N3-
subsituted compounds where R may be the alkyl, aryl, allyl, etc. 5-halogenated
pyrimidine 2,4 dione derivatives represent the novel group of compounds having
anticancer and antibacterial activities with remarkable effect on medicinal application.
The application of solid state microwaves –assisted protocol proved to be of vital
importance in term of energy efficiency and designing a solvent-free eco-friendly
synthetic route with considerable reduced reaction time, excellent yields with easy work
up. High consumption of chemicals for prolonged time has adverse effect on
environment. This is the key reason of pursing solvent free i.e. eco-friendly microwaveassisted
solid state synthetic route.
