Abstract:
The thesis in hand mainly describes the isolation and structure elucidation of compounds from
the ethyl acetate and chloroform soluble fractions. Four new and eight known compounds have
been isolated from Zynthoxylem armatum DC.
New Compounds. 1. 2, 6, 7-trimethoxy-8-(3-methyl-2-butenyl) carbazole-3-carbaldehyde (117)
2. Methyl-2, 6, 7-trimethoxy-8-(3-methyl-2-butenyl)carbazole-3-carboxylate (118)
3. 4-methoxy-12, 12-dimethylcyclopenta furoquinoline-10-carbaldehyde (123)
4. Methyl, 4-methoxy-12, 12-dimethylcyclopenta furoquinoline-10-carboxylate (124)
Known Compounds.
1. Sezamine (119)
2. Methyl Piperitol (120)
3. Fargesin (121)
4. Dictamine (122)
5. Planispine A (125)
6. Planispine B (126)
7. Lupenone (127)
8. Lupeol (128)
A brief discussion on biological activities of various fractions as well as of the isolates is
presented in the present work. It was observed that the compounds 117-122 showed higher anti
oxidant properties than ascorbic acid. The compounds 117, 118 and 122 were found to be more active than the rest of the isolates. The two new furoquinoline alkaloids (123) and (124) showed
significant DPPH radical scavenging activity compared to ascorbic acid. The compound 123 was
found to be more active than compound 124, which was further supported by ABTS radical
scavenging assay.
The n-hexane, ethyl acetate, chloroform and n-butanol fractions were screened for anti
fungal activities against Aspergillus flavus and Aspergillus niger. It was found that ethyl acetate
soluble fraction showed maximum inhibition and decreased the fungal growth by 55.5 and 61%,
chloroform fraction showed moderate inhibition while n-hexane and n-butanol fractions showed
minimum inhibition of the corresponding fungi.
