Abstract:
This dissertation deals with phytochemical and bioactivities studies on indigenous
medicinal plants; Maytenus royleanus (Celastraceae) (Part A), Ficus faveolata
(Moraceae) (Part B) and additional miscellaneous part C (Cyclotetrapeptides
from Aspergillus ochraceopetaliformis).
Part-A
Part A deals with phytochemical and bioactivities studies on the chemical
constituents of the roots of Maytenus royleanus. The systematic phytochemical
studies have led to the isolation and structure elucidation of three new compounds
(1-3). In addition seven known compounds (4-10) have also been isolated for the
first time from this species. Structures have been elucidation by advanced
spectroscopic techniques.
Royleanine A (1)
1β,2β,5β,7β,8β,11-Hexaacetoxy-4-hydroxy-3α,15-[2',3'-dimethyl-3'(5''-carboxy-
2''-pyridyl)-propanoic acid] dicarbolactone-dihydro-agarofuran
Royleanine B (2)
1β,2β,5β,7β,8β,11-Hexaacetoxy-3α,15-[2'-methyl-4'(5''-carboxy-2''-
pyridyl)-butanoic acid] dicarbolactone-dihydroagarofuran
Royleanine C (3)
1β,2β,5β,7β,8β,11-Hexaacetoxy-3α,15-[2'-methyl-2'β-benzoate-4'(4''-
carboxy-2''-pyridyl)-butanoic acid] dicarbolactone-dihydroagarofuran
Salaspermic acid (4)
Orthosphenic acid (5)
3α,22β-Dihydroxyolean-12-en-29-oic acid (6)
Oleuropein (7)
Ligutroside (8)
Quercetin (9)
β-Sitosterol-3-O-β-D-glycopyrannoside (10)
Part-B
Part B deals with isolation and characterization of chemical constituents
from Ficus faveolata. Five compounds were isolated from the stem methanolic
extract of Ficus faveolata; two of them are new (11, 12) and three known
compounds (13-15) hitherto unreported from this source. Their structures have
been elucidated by spectroscopic techniques.
Ficusonic acid (11)
3β,21β-Dihydroxy-olean-12-en-29-oic acid
Ficusonolide (12)
3α-Hydroxylean-12-en-29,19α-olide
Gallocatechine (13)
β-Sitosterol-3-O-β-D-glycopyrannoside (14)
3β,22β-Dihydroxyolean-12-en-29-oic acid(15)
Part-C
Part C is the miscellaneous section which describes the isolation and
characterization of two new Cyclotetrapeptides; ochrine A (16) and ochrine B (17) from
the fungal strain Aspergillus ochraceopetaliformis collected from Hawaii shallow water
sediment. Their structures have been elucidated by modern spectroscopic techniques.