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Sliding mode controller–observer pair for p53 pathway

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dc.contributor.author Azam, Muhammad Rizwan
dc.contributor.author Uppal, Ali Arshad
dc.contributor.author Bhatti, Aamer Iqbal
dc.date.accessioned 2019-11-14T06:43:28Z
dc.date.available 2019-11-14T06:43:28Z
dc.date.issued 2019-07-18
dc.identifier.issn 1751-8857
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/1214
dc.description.abstract A significant loss of p53 protein, an anti-tumour agent, is observed in early cancerous cells. Induction of small molecules based drug is by far the most prominent technique to revive and maintain wild-type p53 to the desired level. In this study, a sliding mode control (SMC) based robust non-linear technique is presented for the drug design of a control-oriented p53 model. The control input generated by conventional SMC is discontinuous; however, depending on the physical nature of the system, drug infusion needs to be continuous. Therefore, to obtain a smooth control signal, a dynamic SMC (DSMC) is designed. Moreover, the boundedness of the zero-dynamics is also proved. To make the model-based control design possible, the unknown states of the system are estimated using an equivalent control based, reduced-order sliding mode observer. The robustness of the proposed technique is assessed by introducing input disturbance and parametric uncertainty in the system. The effectiveness of the proposed control scheme is witnessed by performing in-silico trials, revealing that the sustained level of p53 can be achieved by controlled drug administration. Moreover, a comparative quantitative analysis shows that both controllers yield similar performance. However, DSMC consumes less control energy. en_US
dc.language.iso en_US en_US
dc.publisher IET en_US
dc.subject COMSATS en_US
dc.subject medical control systems en_US
dc.subject proteins en_US
dc.subject variable structure systems en_US
dc.subject control system synthesis en_US
dc.subject tumours en_US
dc.subject robust control en_US
dc.subject robust control en_US
dc.subject drugs en_US
dc.title Sliding mode controller–observer pair for p53 pathway en_US
dc.type Article en_US


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