Abstract:
Four different series of some new di-and triorganotin and organogermanium carboxylates have been prepared. Of them eight compounds of general formula (R1(CH3)2SiCH2)2Sn(O2CCH2(R2)CHGeR33)2 where R1=CH3, C2H5; R2=C6H5, C6H4OMe3/4; R3=CH3, N(CH2CH2O)3 have been synthesized from (R1(CH3)2SiCH2)2SnCL2 AND R33GeCH(R2)CH2CO2H in the presence of triethylamine. Second series of new triorganotin carboxylates containing germanium with general formula
R1GeCHR2CH2COO)Sn(CH2C(CH3)3)3 where R1=N(CH2CH2O)3, C6H5; R2=C6H5, p-C6H4OCH3 and o-/p-C6H4F were synthesized.
Another series of diorganotin(IV) derivatives of general formula (R3'GeCHRCH2COO)2SnR2'' have been prepared by the reaction of diorganotin chlorides/oxides with substituted germyl propionic acids. A series of ten new organogermanium compounds with general formulae C21H16RGeN2O4 and C13H12RGeNO3 have also been prepared from GeO2 by hydrogermanation reaction in the presence of different substituted 3-trichlorogermyl propionic acids. Thus prepared substituted acids were complexed with 8-quinolinol and 2-methyl-8-quinolinol.
All above compounds have been characterized by various analytical techniques such as elemental analysis, IR, multinuclear NMR (1H, 13C, 119Sn) and mass spectrometry. Some selected compounds have also been subjected to Mossbauer spectroscopy. The single crystal structures of precursors like Ph3GeCHRFCH2COOH (RF = 4-FC6H4) and (p-CH3C6H4)3GeCH(Ph)CH(Me)COOH has been determined by X-ray diffraction. Biological studies like cytotoxicity, antibacterial, antifungal enzyme-inhibition and antileishmanial activity have shown their potential in the treatment of leishmaniases and ulcers.
All above data has been tabulated in the form of four research papers complete in all respects either accepted in foreign journal or submitted for publication.
