Pakistan Journal of Pharmaceutical Sciences: Recent submissions

  • Influence of Ibuprofen on the pharmacokinetics of isoniazid 
    M K Saleh; W A Malik; B Ahmad; K H Janbaz; M A Khan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1993-01-01)
    The influence of ibuprofcn (400 mg urally) on the pharmacokinetics of isoniazid (500 mg orally) was evaluated in healthy human subjects (n = 30). Subjects participated in a two way crossover trial, the first dosing condition ...
  • EFFECT OF TEMPERATURE AND HUMIDITY ON THE DISINTEGRATION TIME OF PACKAGED PARACETAMOL TABLET FORMULATIONS 
    IQBAL AHMAD; SHAIKH, RIAZ HUSSAIN (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 1994-01-20)
    A study of the effect of various temperature and humidity conditions on the disintegration time of different brands of packaged paracetamol tablet formulations has been made over a period of six months. Under all the storage ...
  • Short communication: characterization of streptolysin s (sls): storage and stability 
    B A Memon; T H Birkbeck; J H Frerr (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-09)
    The stability of streptolysin S during storage under different conditions has been studied. It is completely stable in 0.1% (w/v) bovine serum albumin supplemented with 20% (v/v) glycerol at -20 degrees C for more than 6 ...
  • Review: scheduling drugs and national legal controls the need for research 
    D C Jayasuriya; I Khan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-09)
    The system of scheduling narcotic drugs and psychotropic substances under national legislation does not always correspond to the system of scheduling under the international drug control treaties. Even though many drugs ...
  • Effect of temperature and humidity on hardness and friability of packaged paracetamol tablet formulations 
    I Ahmad; R H Shaikh (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-08)
    The influence of various temperature and relative humidity conditions on changes in hardness and friability of five commercial brands of packaged paracetamol tablets stored over a period of six months has been investigated. ...
  • Stability of phosphoinosit1des containing liposomes: effects of triton x-100, temperature and 68 rpm 
    M Riaz; N Weiner (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-07)
    The stability of phosphoinositide containing liposomes was investigated. It was found that 2% of triton X-100 completely released entrapped carboxyfluorescein. The release of carboxyfluorescein occurred the most of 58 ...
  • Haemolytic assay for the detection of adenylate cyclase toxin of Bordetella pertussis 
    Y F Kazi; R Parton; B A Memon (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-06)
    The aim of this study was to device a simple, sensitive and convenient assay for the detection of toxicity of the Adenylate cyclase toxin (ACT), a newly recognized toxin of Bordetella pertussis. Haemolytic activity of ACT ...
  • Effect of cobalt (ii), copper (ii), nickel (ii) and zinc(ii) metal ions on the biological activity of triazine derived ligand 
    Z H Chohan; M A Farooq (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-05)
    A new Schiff-base triazine-derived ligand and its cobalt (II), copper (II), nickel (II) and zinc (II) metal complexes have been synthesised and characterised on the basis of elemental analysis, molar conductance, infrared, ...
  • Estimation of nor-adrenaline content of human penile tissue in diabeticmen with/without neuropathy 
    S T Ali; R N Shaikh; N A Siddiqui; P Q Raza (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-04)
    Penile tissue consisting of corps cavernosum (cc) and tunica albuginea (TA) was obtained from 35 impotent patients undergoing surgery for implantation of penile prostheses and was examined for nor adrenaline content. 10 ...
  • Biochemical alterations during swimming induced stress 
    S I Ahmad; S P Ahmed; R Najam; T Sharafatullah; N Aruj (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-03)
    Stress can be defined as any stimulus that creates an imbalance in the internal environment. Hypothalamus has sensors that detect changes produced in the body. Stress can cause diseases by altering immune system, cardiovascular ...
  • Amino Acid analysis of intellan, a herbal product used in enhancing brain function 
    Shahnaz Ahmed; Atiq Ur Rehman; Kaneez Fatima (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-02)
    Analysis of the drug "INTELLAN" and two reputed plants i.e. Centella asiatica and Herpestis monniera used in the preparation of the drug reveals that glutamic and aspartic acids are present in high concentration in the ...
  • Studies on marine algae for haemagglutinic activity 
    Mohammad Tanweer Alam; K. Usmanghani (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-07-01)
    Lectins (agglutinins) are important in medical and immunological applications. Phytohaemagglutinins have been found useful in blood banking. Keeping in view of these facts, the marine algae found at Karachi coastal region ...
  • DNA repair, cancer and gene therapy 
    S A Rasool; R Ali; A Mirza; T Yasmeen; R Mushtaque (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-11)
    Fidelity of DNA synthesis is pivotal to our understanding of fundamental biological processes. An organism must replicate and repair its DNA with high accuracy and precision in order to maintain its genetic activity. DNA ...
  • Biochemical and electrophoretical studies of the effect of some chemosterilants on theenzymes of aedes aegypti (L.) larvae 
    S N Naqvi; H M Sulaiman; A M Mohammad; M Afzal (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-10)
    In vivo effect of standard and prospective chemosterilants on some enzymes is reported. Colorimetric and histochemical findings indicate that alkaline phosphatase is inhibited by shikonin, hempa, tepa and shikonin angelate. ...
  • Determination of toxicity of danitol, methoprene and neem formulation against stored grain pest, sitophilus oryzae L 
    R Tabassum; M Jahan; M A Azmi; S N Naqvi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-09)
    Toxicity of a synthetic pyrethroid (Danitol 10 E.C.), methoprene (J.H.A.) and crude neem extract formulation (RB-b +PBO +Tx) in synergestic form was determined in laboratory by contact method against adults of Sitophilus ...
  • In vitro antibacterial studies of some newly synthesized phenacyl-thiosemicarbazones 
    S M Khalid; S A Khan; M Arif; S Shafiq; Z S Saifi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-08)
    Four different phenacyl-thiosemicarbazone compounds were studied for their antibacterial activity against seventeen different species/strains. Of the four compounds under study, O-methoxy- phenacyl-thiosemicarbazone was ...
  • Biflavone from mangifera indiga 
    M A Khan; S S Nizami; M N Islam; S W Azeem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-07)
    The phenolic extractive of the bark of Mangifera indica yielded a known biflavone which was characterized by spectral and chemical methods as amentoflavone. This is the first report for the isolation of biflavon from ...
  • A study of comparative blood absorption of vitamin b(1) from different B-complex preparations 
    O Ahsan; A R Memon; I Ahmad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-06)
    In order to judge the therapeutic efficacy of thiamine (vitamin B(1)) in B-complex preparations, three commercial syrup preparations were analysed for thiamine content and their blood absorption in rabbits was compared ...
  • Cyclic voltammetric adsorption behaviour of riboflavin at platinum electrode 
    W Hussein; D Waqar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-05)
    Cyclic voltammetric technique has been used to determine the electrochemical adsorption behaviour of riboflavin at platinum disc electrode in acidic solution. The electrode loses its activity after the first cyclic curve ...
  • Screening of marine algae of karachi for haemagglutinin activity 
    S B Shyum; D Sheikh; K Usmanghani; M Shameel; R Sheikh (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-04)
    Ethanol extracts of 66 species of marine benthic algae, collected from the coastal areas of Karachi, Pakistan, were tested for haemagglutination against human erythrocytes of blood groups A, B, AB and O. Out of 23, 16 and ...

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