Pakistan Journal of Pharmaceutical Sciences: Recent submissions

  • RNA interference in the progress of gastric cancer 
    Wu, Lihua; Zhang, Sisen; Liu, Qing; Shi, Xiaoxin; Zheng, Yingbin (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-13)
    Gastric cancer is one of common malignant tumors. The development of molecular biology and genetics prompts people to regulate tumor cell regulation from the gene level, and seeks method to the new tumor therapy. RNA ...
  • Influence of smoothened siRNA on human esophageal cancer cell line EC9706 proliferation and apoptosis 
    Hui, Wu; Kuisheng, Chen; Hongxin, Zhang; Yanzhi, Ding; Zhihua, Zhao; Hu, Zhang (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-12)
    Apply siRNA technology to take Smoothened (Smo) genetic locus, the possibility of Hh signaling pathway, and also inhibits esophageal squamous carcinoma cell proliferation and induction of apoptosis. Utilizing Smo siRNA ...
  • Effect and mechanism of miRNA to osteosarcoma cell 
    Tian, Ke; Wang, Limin; Di, Ruiqing; Xu, Jianzhong; Li, Guangheng; Li, Zhifu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-11)
    MicroRNA has proved to be low expression in many tumor cells. In addition, it was also proved that as a kind of cancer suppressor gene, miR-199a-3p in miRNA can affect the growth and invasion ability of tumor cells. This ...
  • Study on effect of the expression of siRNA in gastric cancer bearing nude mice transplanted tumor NEDD9 gene 
    Zhang, Sisen; Wu, Lihua; Liu, Qing; Chen, Kuisheng; Zhang, Xiefu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-10)
    The clinical study found that NEDD9 showed high expression on the invasion in gastric cancer tissues and metastasis of the tumor. Based on promoting the fundamental role (Sisen et al., 2013) to the expression level, the ...
  • Curative effect research on curing intercostal neuralgia through paravertebral nerve block combined with pregabalin 
    Xiao, Peng; Zhu, Xu; Wu, Xuejian (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-09)
    This paper aimed to discuss the curative effect and safety of curing intercostal neuralgia through paravertebral nerve block combined with pregabalin. 90 cases of patients diagnosed as intercostal neuralgia were taken as ...
  • Research for the influence of telomerase inhibitors on myeloma cell and therapy 
    Zhihua, Zhao; Miaomiao, Sun; Jianping, Yang; Kuisheng, Chen (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-08)
    This paper aims to study the effect of telomerase inhibitors zidovudine (AZT) on cell morphology, survival rate and telomerase activity of in-vitro culture myeloma cell line (U266). It has provided experiment basis for ...
  • Distribution of selenium and cadmium in soil-rice system of seleniumrich area in Hainan, China 
    Wang, Dengfeng; Wei, Zhiyuan; Tang, Shumei; Qi, Zhiping (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-07)
    Rice, which is the staple food in East Asia, is a source of Selenium (Se) and Cadmium (Cd). The distribution of Se and Cd in soil-rice system is significant to human nutrition and public health. This study is to explore ...
  • Research on antioxidant activity of EOB-F and its function in the diagnosis of heart and cerebral vessels 
    Wang, Zhengbin; Han, Zhanying; Qiu, Chunguang; Huang, Zhenwen; Sun, Guoju; Lu, Wenjie; Chen, Xiaojie; Qin, Xiaofei (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-06)
    This paper introduces the research progress related to the antioxidant activity of bamboo leaf flavonoid (EOBf) and its pharmacological activity of heart and cerebral vessels. The paper studied what role EOB-f played in ...
  • Study on novel galantamine hydrobromide sustained-release capsules and its in vitro releasing property 
    Li, Kun; Yang, Shuoye (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-05)
    In present study, we prepared a novel galantamine hydro bromide sustained-release capsules with the new manufacturing technology, extrusion-spheronization method, and the optimized preparative formulation. A simple, rapid ...
  • Dissolution profile study on the novel doxycycline hydrochloride sustained-release capsules 
    Yang, Shuoye; Li, Kun (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-04)
    In present study, a novel doxycycline hydrochloride (DC) sustained-release capsule was prepared with the new manufacturing technology, extrusion-spheronization method. The release studies were performed using marketed ...
  • Preparation and catalytic performance of temperature-responsive cell-like particles 
    Yang, Qiufeng; Dai, Zhao; Guo, Wenjuan; Chu, Yuanyuan; Chen, Guangping (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-03)
    A novel kind of cell-like particles as temperature-responsive catalysts was presented in this paper. First, uniform α-Fe2O3 shuttle-like nanoparticles were prepared by homogeneous hydrolysis. Then, these α-Fe2O3 particles ...
  • Predicting the long-term toxicity of five-antibiotic mixtures to Vibrio qinghaiensis sp. Q67 
    Zhang, Jin; Chen, Qiong (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-02)
    Concentration addition (CA) is commonly used as a standard additive reference model to predict the shortterm toxicity for most chemical mixtures. Whether CA can predict the long-term toxicity of antibiotic mixtures ...
  • The research for the relationship between nutritional status of vitamin A in infant's body and immunization effect of hepatitis B and measles vaccine 
    Ni, Shumei; Wei, Ling; Liu, Ying; Tang, Jinglei (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2014-09-01)
    This paper is to discuss the relationship among the nutritional status of vitamin A in infant's body, antibody level of hepatitis B's surface and antibody concentration of measles IgG. 2ml of infant's venous blood is ...
  • A mini-review of therapeutic potential of Mangifera indica L. 
    Nazima Batool; Noshin Ilyas; Sumera Shabir; Maimoona Saeed; Roomina Mazhar; Amjid, Muhammad Waqas (Karachi: Pakistan Botanical Society, University of Karachi, 2018-07-20)
    Among known species of 69 Mangifera, Mangifera indica L. is a medicinal plant being used in tropical regions by indigenous people. It has been a main plant species being used in Ayurvedic as well as indigenous medical ...
  • REVIEW Nanoparticles toxicity and their routes of exposures 
    Yah, Clarence Suh; Simate, Geoffrey Simate; Iyuke, Sunny Esayegbemu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2012-04-29)
    The new scientific innovation of engineering nanoparticles (NPs) at the atomic scale of 100 nm or less, has led to numerous novel and useful wide applications in electronics, chemicals, environmental protection, biological ...
  • REVIEW Pharmacogenomic approaches in the treatment of breast cancer by tamoxifen 
    Sidra Ameen; Muhammad Imran Qadir; Bashir Ahmad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2012-04-28)
    Breast cancer (BC) is a highly diverse complaint rather than sole disease consisting of several markers linked to typical features of tissues, medical assessment and reaction to treatment. Mutation in RAS/MEK/ERK and ...
  • Immunological study of different fraction of wheat proteins 
    Shaista Khan; Khaskheli, Muhammad Hassan; Ghulam Nabi; Deverajani, Bikha Ram; Naima Memon; Shar, Ghulam Abbas (Karachi: Pakistan Botanical Society, University of Karachi, 2018-07-20)
    Wheat allergy specifically refers to the adverse reaction involving IgE antibody to one or more protein fraction of wheat such as albumin, globulin, gliadin and glutenin (gluten). The majority of IgE-mediated reactions ...
  • REPORT Antimicrobial activities of rhizomes of Polygonatum verticillatum: Attributed to its total flavonoidal and phenolic contents 
    Haroon Khan; Muhammad Saeed; Naveed Muhammad; Rukhsana Ghaffar; Khan, Saeed Ahmad; Sohail Hassan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2012-04-27)
    The current study was undertaken to evaluate the rhizomes of Polygonatum verticillatum against various pathogenic bacteria and fungi. Broad spectrum antibacterial activity was demonstrated by the crude extract of the plant ...
  • REPORT Phytochemical screening, and assessment of ameliorating effect of aqueous and ethanolic extracts of Gmelina arborea on drug induced hepatic and renal insufficiency in rats 
    Anthony, Ogbonnaya Enyinnaya; Mbuh, Awah Francis; Emmanuel, Mounmbegna Philippe (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2012-04-26)
    Phytochemical screening of stem bark and leaves of Gmelina arborea; and effect of aqueous and ethanolic extracts of Gmelina arborea stembark on hepatic and renal insufficiency in rats was assessed in this study. Phytochemical ...
  • REPORT Improved physicochemical characteristics of artemisinin-nicotinamide solid dispersions by solvent evaporation and freeze dried methods 
    Muhammad Tayyab Ansari; Humayun Pervez; Muhammad Tariq Shehzad; Zahid Mahmood; Muhammad Tahir Razi; Nazar Muhammad Ranjha; Nuzhat Khanum (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2012-04-25)
    Artemisinin (ARMN) is a drug of choice against drug-resistant malaria especially due to Plasmodium falciparum. Being poorly soluble in water, its solid dispersions with nicotinamide (NA) were prepared at various drug-carrier ...

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