Pakistan Journal of Pharmaceutical Sciences: Recent submissions

  • ANTIOXIDANT ACTIVITY OF COVOLVULUS HYSTRIX VAHL AND ITS CHEMICAL CONSTITUENTS 
    DONIA, ABD EL RAHEIM MOHAMMED; ALQASOUMI, SALEH IBRAHIM; AWAAD, AMANI SHAFEEK; CRACKER, LYLE (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-08)
    Total alcohol and successive extracts (diethyl ether, chloroform, ethyl acetate and n-butanol) of Covolvulus hystrix Vahl were screened for their antioxidant activity using free radical 2-2- diphenyl-1-picrylhydrazyl (DPPH) ...
  • HEPATOPROTECTIVE STUDIES ON HALOXYLON SALICORNICUM: A PLANT FROM CHOLISTAN DESERT 
    MAHMOOD AHMAD; SOFIA ERAM (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    The objective was to study the in-vivo hepatoprotective effect of aerial parts of Haloxylon salicornicum (Moq.) Bunge (Family: Chenopodiaceae) in order to validate its traditional use in hepatobiliary disorders, by ...
  • PRODUCTION OF ACTEOSIDE FROM CISTANCHE TUBULOSA BY β-GLUCOSIDASE 
    ZHAO, SHU-YAN; HE, XIU-YAN; JIA, BAO-GUO; PENG, QING-YUN; LIU, XIN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-07)
    Acteoside and echinacoside are the major active components of Herba Cistanches. Facilitated β-glucosidation was investigated as a means of increasing harvest of acteoside from Cistanche tubulosa. Fresh Cistanche tubulosa ...
  • PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF ANNONA SQUAMOSA LINN IN ISONIAZID-RIFAMPICIN INDUCED HEPATOTOXICITY IN RATS 
    MOHAMED SALEEM THATTAKUDIAN SHEIK UDUMAN; RAMKANTH SUNDARAPANDIAN; AZAGUSUNDHARAM MUTHUMANIKKAM; KALIMUTHU, GNANAPRAKASH; PARAMESWARI S, ANGALA; SRINIVAS, THIRUVENGADA RAJAN VASANTHI; KARUNAKARAN, GAUTHAMAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-06)
    The present study was made to investigate the protective effect of methanolic extract of Annona squamosa on isoniazid-rifampicin-induced hepatotoxicity in rats. Rats were divided into five different groups (n=6), group ...
  • FLAVONOIDS OF ENHYDRA FLUCTUANS EXHIBITS ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY IN DIFFERENT ANIMAL MODELS 
    SANTANU SANNIGRAHI; MAZUMDER, UPAL KANTI; DILIPKUMAR PAL; SILPI LIPSA MISHRA; SUBHASIS MAITY (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Enhydra fluctuans (Compositae), an edible semi aquatic herbaceous vegetable plant, widely used in traditional system of Indian medicine. Total flavonoids of E. fluctuans (TFEF) were screened for analgesic and antiinflammatory ...
  • THE PROTECTIVE ROLE OF GLUTATHIONE IN SILVER INDUCED TOXICITY IN BLOOD COMPONENTS 
    KHAN, HAROON; KHAN, MUHAMMAD FARID; ASIM-UR-REHMAN; SYED UMER JAN; NASEEM ULLAH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-05)
    Silver Nitrate (AgNo3) effect on the status of reduced glutathione (GSH), the major non-protein thiol in blood components were examined using freshly isolated plasma and cytosolic fraction of whole blood of healthy human ...
  • INTESTINAL PERMEABILITY STUDIES OF SULPIRIDE INCORPORATED INTO SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) 
    CHITNENI, MALLIKARJUN; KOK KHIANG PEH; YUSRIDA DARWIS; MUTHANNA ABDULKARIM; GHASSAN ZUHAIR ABDULLAH; QURESHI, MOHAMMED JAVED (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-04)
    The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective permeability ...
  • EFFECTS OF AEGELINE, A MAIN ALKALOID OF AEGLE MARMELOS CORREA LEAVES, ON THE HISTAMINE RELEASE FROM MAST CELLS 
    NUGROHO, AGUNG ENDRO; SUGENG RIYANTO; SUKARI, MOHAMAD ASPOLLAH; KAZUTAKA MAEYAMA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Aegeline or N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide is a main alkaloid isolated from Aegle marmelos Correa collected in Yogyakarta Indonesia. In our study, we investigated the effects of aegeline on ...
  • SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SCHIFF BASES OF [4-(AMINO) -5- PHENYL- 4H-1, 2, 4-TRIAZOLE- 3- THIOL] 
    JUBIE, SELVARAJ; PRANABESH SIKDAR; ANTONY, SHANISH; KALIRAJAN, RAJAGOPAL; GOWRAMMA, BYRAN; GOMATHY, SUBRAMANIAN; ELANGO, KANNAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-03)
    The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using water as solvent under reflux condition for 3-4 h. The compound ...
  • SECONDARY DEFENSE ANTIOXIDANT STATUS OF VITAMIN C, VITAMIN E AND GSH IN MALARIA, CAUSED BY PLASMODIUM FALCIPARUM AND PLASMODIUM VIVAX 
    TARIQ JAVEED; TARIQ JAVEED; KHAN, IKRAMULLAH; KHAN, MUHAMMAD KHALID (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-02)
    Present investigations focused on the antioxidant defense in malaria caused by plasmodium Falciparum and plasmodium Vivax the mean ±SEM values of Vitamin C, Vitamin E and GSH very highly significantly decreased as compared ...
  • DETERMINATION OF TOXIC METALS IN SOME HERBAL DRUGS THROUGH ATOMIC ABSORPTION SPECTROSCOPY 
    BUSHRA HINA; RIZWANI, GHAZALA HAFEEZ; SHAHID NASEEM (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    This study presents a picture of occurrence of heavy metals (Pb, Cd, Cu, Cr, Co, Fe, Ni, Zn) in some selected valuable herbal drugs (G. glabra, O. bracteatum, V. odorata , F. vulgare, C. cyminum, C. sativum, and ...
  • ROLE OF CHLAMYDIA PNEUMONIAE, HELICOBACTER PYLORI AND CYTOMEGALOVIRUS IN CORONARY ARTERY DISEASE 
    ABDULLAH AL-GHAMDI; ASIF AHMED JIMAN-FATANI; HASSAN EL-BANNA (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2011-04-01)
    Coronary artery disease (CAD) is the leading cause of death in many countries. The underlying mechanism of the chronic inflammatory process in atherosclerosis is still unknown. As a possible trigger, different viruses ...
  • PHYTOCHEMICAL ANALYSIS, ANTIOXIDANT AND ANTIBACTERIAL EFFECTS OF SEA BUCKTHORN BERRIES 
    SAADIA CHAMAN; SYED, NAWAZISH-I-HUSAIN; ZEESHAN DANISH; KHAN, FARRAKH ZIA (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Sea buckthorn berries are therapeutically used as folk medicine for a variety of diseases, however, the scientific evidence is hardly available to support their role. This study explored their chemical constituents and ...
  • Enhanced production of streptokinase from Streptococcus agalactiae EBL-31 by response surface methodology 
    Arooj Arshad; Muhammad Anjum Zia; Muhammad Asgher; Joyia, Faiz Ahmad; Muhammad Arif (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-23)
    Streptokinase (SK) is a fibrinolytic protein used for the treatment of cardiovascular disorders. In the present study, enhanced production of SK was achieved by determining the optimum fermentation conditions for the ...
  • Molecular basis of quinolone resistance in clinical isolates of Klebsiella pneumoniae from Pakistan 
    Roman Farooq Alvi; Bilal Aslam; Naveed Shahzad; Muhammad Hidayat Rasool; Muhammad Shafique (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-21)
    Antibiotic resistant Klebsiella pneumoniae, is associated with various nosocomial infections that are difficult to treat. This study is designed to find out the patterns of resistance against commonly used antibiotics in ...
  • INTERACTION STUDY OF MOXIFLOXACIN AND LOMEFLOXACIN WITH CO-ADMINISTERED DRUGS 
    GANDHIMATHI MURUGANATHAN; NAIR, DHANYA KONDAYIL; NATARAJAN BHARATHI; RAVI, THENGUNGAL KOCHUPAPY (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    Moxifloxacin and lomefloxacin are fluoroquinolone antibiotics used in treating urinary and respiratory tract infections. Fluoroquinolones are known to have interactions with drugs that are active in gastro intestinal tract. ...
  • Enhanced production of Lovastatin by filamentous fungi through solid state fermentation 
    Naveed Munir; Muhammad Asghar; Mian Anjum Murtaza; Naheed Akhter; Ghulam Rasool; Syed Muhammad Ali Shah; Imtiaz Mahmood Tahir; Khan, Fahad Said; Muhammad Riaz; Sabira Sultana; Sabira Sultana; Muhammad Akhlaq; Muhammad Akram (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-20)
    Lovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with ...
  • Role of ibuprofen and lavender oil to alter the stress induced psychological disorders: A comparative study 
    Sara Qadeer; Shaista Emad; Shaista Emad; Sarwat Yousuf; Sheeza Sheikh; Yousra Sarfaraz; Sana Sadaf; Saida Haider (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-19)
    Stress has become an integral feature of everyday living. Each individual that lives encounters some manifestation of stress in life. Stress causes certain alterations in the structure and functions of the body and is ...
  • ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF DIFFERENT FRACTIONS OF COCCINIA CORDIFOLIA L. ON NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS 
    MD. ARIFUL ISLAM; KHAN, RAFIQUL ISLAM; SAROWAR HOSSAIN; KHURSHID ALAM; IMAM IBNE WAHED; BYTUL M. RAHMAN; ASM ANISUZZAMAN; SHARIF MD. SHAHEEN (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2011-07-20)
    The present study was carried out to observe the antidiabetic and hypolipidemic effects of petroleum-ether, ethyl acetate and chloroform fractions isolated from ethanolic extract of the leaves of Coccinia cordifolia ...
  • High performance liquid chromatographic method validation for determination of rosuvastatin calcium in tablet dosage forms 
    Madiha Moid; Sidra Afzal; Najia Rahim; Tariq Ali; Wajiha Iffat; Lubna Bashir; Shazia Naz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-07-18)
    A precise, sensitive and quick High Performance Liquid Chromatographic (HPLC) method for the determination of rosuvastatin calcium in bulk and tablet dosage forms has been validated. The chromatographic scheme involved: ...

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