Pakistan Journal of Pharmaceutical Sciences: Recent submissions

  • Multicomponent spectrophotometric assay of cyanocobalamin, hydroxocobalamin and riboflavin 
    I Ahmad; W Hussain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-03)
    The photolysis of cyanacobalamin to hydroxocobalamin in aqueous solution is influenced by riboflavin. A multicomponent spcctrophotometric method has been developed for the simultaneous determination of cyanocobalamin, ...
  • Viscosity and stability stijdies of hydroxypropyl methylcellulose polymer solutions 
    A J Ferdous (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-02)
    Viscosity studies of three grades of hydroxypropyl methylcellulose polymer solutions have been done in detail. The solutions showed pseudoplastic behaviour and their viscosity increased with increase in concentration of ...
  • cularine-type alkaloids from corydalis rutifolia subsp. erdellII 
    Bilge sener; Hulya Temizer; Mehmet Koyuncu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1992-07-01)
  • Short communication: studies on punica granatum-I isolation and identification of some constituents from the seeds of punica granatum 
    R Ahmed; S M Ifzal; A Saifuddin; M Nazeer (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1995-01-08)
    Initial phytochemical screening of the seeds of Punica granatum has revealed the presence of Ursolic acid and beta-Sitosterol alongwith a long straightchain hydrocarbon - nonacosene. Presence of estrogens and glycosides ...
  • Short communication: guidelines to good manufacturing practices (g.m.p.) in pharmaceutical manufacturing 
    R H Shaikh; A A Sial (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1995-01-07)
    The object of the GMP and associated rules is the assurance of the quality of the products for the safety, well being and protection of the patient. In achieving this aim it is impossible to over-emphasise the importance ...
  • Studies on the antimicrobial activity of honey 
    D Sheikh; S Zaman; S B Naqvi; M R Sheikh; G Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-01-06)
    Ten samples of crude and processed honey were used to determine antimicrobial activity against twenty five species of pathogenic and nonpathogenic bacteria, commonly encountered in human infections. The antifungal activity ...
  • Effect of cimetidine, ranitidine and tiotidine on plasma testosterone and luteinizing hormone levels in rats 
    R T Mahmud; M S Akhter (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1994-01-06)
    This investigation was carried out to study the comparative effects of cimetidine, ranitidine and tiotidine on the plasma levels of testosterone and luetinizing hormone under local conditions. The three H(2)-blocking drugs ...
  • Conductometric study of interaction between dyes and surface active agents 
    D Waqar; M Alam; W Hussein (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1995-01-05)
    The interaction of anionic surface active agents e.g. sodium decyl sulphate (SDS), sodium dodecyl sulphate (SDDS), sodium tetradecyl sulphate (STDS), sodium hexadecyl sulphate (DHDS) and sodium octadecyl sulphate (DODS) ...
  • Antimicrobial studies of the leaf of cannabis sativa L 
    K Wasim; I Haq; M Ashraf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1995-01-03)
    In vitro antimicrobial studies were conducted with aqueous, ethanolic and Petroleum ether extracts of the leaves of Cannabis sativa L. The acidic fraction was obtained from the ethanolic extract and 2% Sodium Hydroxide ...
  • Acetylation percentage method for determination of acetylator status in human volunteers and tuberculous patients 
    A S Sohrani; B Ahmad; K H Janbaz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1995-01-02)
    Acetylation percentage method described here is rapid and economical. A comparison has been made between plasma half life (t (1/2)), acetylation ratio and acetylation percentage methods for the determination of phenotyping. ...
  • A study on comparative efficacyof hypolipidemic drugs 
    A Sher; A Ullah; A Mateen (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1995-01-01)
    A study was carried out on the comparative efficacy of Lopid, Mevacor, Bezalip and Lasona in sixteen hyperlipidemic subjects. All the subjects were on Lopid at least for the last 15 days. Lopid therapy was discontinued ...
  • NEUROCHEMICAL AND BEHAVIOURAL EFFECTS OF LONG TERM INTAKE OF TEA 
    SAIDA HAIDER; ANILA YASMEEN; TAHIRA PARVEEN; DARAKHSHAN J. HALEEM (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1998-07-08)
    Tea consumption in many cases is the main source of caffeine intake in humans. In the present study neurochemical and behavioural effects of long term tea intake are monitored in rats. Long term tea administration did not ...
  • HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONSHIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONS 
    M.Y. KHUHAWAR; F.M.A. RIND (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1998-07-07)
    Isoniazid (IS) individually or in the presence of pyrazinamide and rifampicin has been determined by high performance liquid chromatography (HPLC) after derivatization with 6-methyl-2-pyridinecarboxaldehyde. Pyrazinamide ...
  • COMPARATIVE ANALYSIS OF PULSED (ACTIVATED) AND RESTING CHICKEN CYTOCHROME C OXIDASES WITH SODIUM CHLORIDE DEPENDENCE OF THE ENZYME 
    MUHAMMAD NISAR ALIZAI; WILSON, M.T.; NISAR MUHAMMAD NISAR (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1998-07-06)
    Comparative investigation of pulsed (activated) chicken cytochrom c oxidase and resting enzyme are compared with other species and pH dependent properties are also monitored Sodium chloride dependence of chicken oxidase ...
  • RESISTANCE PATTERN OF CLINICAL ISOLATES FROM CASES OF CHRONIC EAR INFECTION II 
    ADAM ALI; S. BAQAR SHYUM NAQVI; DILNAWAZ SHEIKH (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1998-07-05)
    During present study hundred clinical isolates from cases of ear infection were tested from local population for resistance pattern, using eleven different antibiotics. A considerable percentage of isolates causing ear ...
  • EFFECT OF CHLORPROMAZINE ON BRAIN BIOGENIC AMINES IN NORMAL AND HYPERGLYCEMIC STATE 
    SHAMOONA TAKWEEN; SHAHIDA P. AHMED; SAIDA HAIDER; DARAKSHAN J. HALEEM (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1998-07-03)
    In present study the effects of chlorpromazine (CPZ) were studied on NA, DA and its metabolities i.e. DOPAC and HVA as well as on 5-HT and its metabolite 5-HIAA in normal and hyperglycemic rats. Significant differences ...
  • PHYTOCHEMICAL AND ANTIMICROBIAL STUDIES OF SALVIA SPLENDENS SELLO 
    KHAN, F. ZIA; M. ASIF SAEED (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1998-07-03)
    The phytochemical investigation of antimicrobial agents from locally occurring Salvia splendens Sello, was carried out. Three common solvents i.e. petroleum ether (40-60%), chloroform and methanol were successively used ...
  • PLATELET ACTIVATING FACTOR ANTAGONISTS 
    SYEDA AFROZ; AZMAT ARA; M. ARIF (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1998-07-02)
    Platelet Activating Factor (PAF) is a D-glycerol derived phosopholipid which is a potent endogenous mediator of inflammation. PAF is synthesized and released by a variety of cell types and elicits its biological activity ...
  • VISCOSITY STUDIES ON MESTRANOL 
    SHAMIM AKHTAR; TAUQIR AHMAD; FAUZIA HASSAN; M. ARIF; SOHAIL HASSAN (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1998-07-01)
    The viscosity of 1x10-4M to 4x 10-4M solution of Mestranol (synthetic oestrogenic steroidal hormone) in thanol was measured at 32o , 40° and 50°C in a viscometric bath. The viscosity rates are maximum at 30°C as compared ...
  • A STUDY ON THE EFFECTS OF SOME NEW DERIVATIVES OF PIPERIDINE ON NEUROTRANSMITTERS 
    Z.S. SAIFY; HANIFA SHAHNAZ; SHAMIM AKHTAR; MOAZZAM HAIDER; DARAKHSHAN JABEEN HALEEM (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 1999-01-07)
    Four chemically synthesized derivatives of piperidine were subjected to evaluate their pharmacological actions on Nervous System in male albino mice. The effects on neurotransmitters such as catechol amine and indolamine ...

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