Pakistan Journal of Pharmaceutical Sciences: Recent submissions

  • Isolation and characterization of different strains of Bacillus licheniformis for the production of commercially significant enzymes 
    Maria Ghani; Asma Ansari; Afsheen Aman; Rashida Rahmat Zohra; Nadir Naveed Siddiqui; Shah Ali Ul Qader (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-06)
    Utilization of highly specific enzymes for various industrial processes and applications has gained huge momentum in the field of white biotechnology. Selection of a strain by efficient plate-screening method for a specific ...
  • Identification of Sulfamoylbenzamide derivatives as selective Cathepsin D inhibitors 
    Waseem Ahmed; Khan, Ishtiaq Ahmad; Muhammad Nadeem Arshad; Waseeq Ahmad Siddiqui; Muhammad Abdul Haleem; Muhammad Kamran Azim (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-05)
    Aspartic proteases play very important role in post translational processing of proteins and several of them are essential for organism’s viability. Here we present the enzyme inhibition activities of different ...
  • Prolonged preconditioning with natural honey against myocardial infarction injuries 
    Eteraf-Oskouei, Tahereh; Shaseb, Elnaz; Ghaffary, Saba; Moslem Najafi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-04)
    Potential protective effects of prolonged preconditioning with natural honey against myocardial infarction were investigated. Male Wistar rats were pre-treated with honey (1%, 2% and 4%) for 45 days then their hearts were ...
  • Hypoglycaemic effects of alcoholic root extract of Borassus flabellifer (Linn.) in normal and diabetic rats 
    Debnath, Titas; Radhakrishnan, Rajesh; Gopal, Murugananthan; Sahil Talwar; K, Nandakumar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-03)
    The objective of the study was to investigate the alcoholic (ALEBF) extract of B. flabellifer for their hypoglycaemic effects in normal and diabetic rats. Diabetes was induced in rats by single dose administration of ...
  • Counter irritant activity of Carthamus oxycantha 
    Syed Saeed ul Hassan; Imran Waheed; Muhammad Khalil-ur-Rehman; Uzma Niaz; Muhammad Asif Saeed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-02)
    Many locally occurring species of Asteraceae are used as medicinal plants by various tribal and ethnic communities in Pakistan. Carthamus oxycantha is often occurs as weed in cultivated fields. Folk medicines indicated ...
  • Formulation development and evaluation of Diltiazem HCl sustained release matrix tablets using HPMC K4M and K100M 
    Faaiza Qazi; Muhammad Harris Shoaib; Rabia Ismail Yousuf; Tanveer Mustafa Qazi; Zafar Alam Mehmood; Syed Muhammad Farid Hasan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2013-07-01)
    The aim of this study was to develop a sustained release hydrophilic matrix tablet of Diltiazem HCl and evaluates the effect of formulation variables (e.g. lubricant, binder, polymer content and viscosity grades of HPMC) ...
  • Epigallocatechin gallate inhibits corneal neovascularization in ratalkaline burn model 
    Li, Huiyan; Ye, Bei; Zhu, Lili; Wu, Lianqun (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-17)
    To evaluate the effectiveness of epigallocatechin gallate (EGCG) in inhibiting corneal neovascularization in rat alkaline burn model. Corneal neovascularization model was induced by sodium hydroxide alkaline burn injury ...
  • Aryl sulfonate based anticancer alkylating agents 
    Sheikh, Hamdullah Khadim; Tanzila Arshad; Ghazala Kanwal (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-16)
    This research work revolves around synthesis of antineoplastic alkylating sulfonate esters with dual alkylating sites for crosslinking of the DNA strands. These molecules were evaluated as potential antineoplastic cross ...
  • Anticholinergic drug atropine diminishes newly formed fear memory in male rats 
    Sahar Rafiq; Saara Ahmad; Fatima Ahmed; Zehra Batool; Saad Bilal Ahmed; Sadia Saleem; Fizza Naqvi; Laraib Liaquat; Asia Afzal; Saida Haider (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-15)
    Post-traumatic stress disorder (PTSD) is a condition which is triggered shortly after experiencing traumatic events. PTSD is complicated by the fact that people with PTSD often develop additional disorders such as phobias, ...
  • Synthesis, characterization and antihypertensive activity of 2-phenyl substituted benzimidazoles 
    Khan, Muhammad Tariq; Muhammad Tahir Razi; Syed Umer Jan; Muhammad Mukhtiar; Rahman Gul; IzharUllah; Abid Hussain; Asif Mehmood Hashmi; Muhammad Taufiq Ahmad; Nisar Ahmed Shahwani; Imran Rabbani (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-14)
    Hypertension is one of cardiovascular disease that is not sufficiently prevented and controlled at both hospital and community levels. Hypertension resulted in significant morbidity and mortality. The benz-imidazole ring ...
  • Hypoglycemic and hypolipidemic activities of crude seeds of Centratherum anthelminticum in healthy volunteers and type 2 diabetic patients 
    Hina Akram Mudassir; Qureshi, Shamim Akhter; Muhammad Bilal Azmi; Muhammad Ahsan; Musab Kamran; Sakina Jafar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-13)
    This study first time reports the hypoglycaemic activity of crude seeds powder (CSP) of Centratherum anthelminticum in healthy and type 2 diabetic volunteers. In addition, hypolipidemic effect of same CSP was also determined ...
  • 2-{[5-(Substituted-phenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(1,3- thiazol-2-yl)acetamides: New bi-heterocycles as possible therapeutic agents 
    Muhammad Shahid Ramzan; Abbasi, Muhammad Athar; Aziz-ur-Rehman; Sabahat Zahra Siddiqui; Syed Adnan Ali Shah; Muhammad Ashraf; Bushra Mirza; Hammad Ismail (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-12)
    An electrophile, N-(1,3-thiazol-2-yl)-2-bromoacetamide (3), was synthesized by the reaction of 1,3-thiazole-2- amine (1) and 2-bromoethanoyl bromide (2) in an aqueous medium. A series of carboxylic acids, 7a-j, were ...
  • Effect of aerobic exercise combined with ginkgo polysaccharide on weight, blood glucose and glycosylated serum protein in diabetic rats 
    Zhu, Rongkun; Xie, Jun (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-11)
    Streptozotocin copied diabetic rats model were studied through aerobic exercise combined with ginkgo polysaccharide. Aimed to offering the updating experimental basis to prevent diabetic through aerobic exercise combined ...
  • Out of pocket (OOP) cost of treating hypertension in Karachi, Pakistan 
    Nousheen Aslam; Muhammad Harris Shoaib; Rabia Bushra; Faraz Ahmed Farooqi; Farya Zafar; Huma Ali; Saima Saleem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-10)
    Pakistan is categorized to below to middle income countries where two third of the national annual health expenditure is in the form of out of pocket (OOP) cost. A prevalence based study was conducted to determine the OOP ...
  • Chemical composition and antioxidant activity of phenolic compounds from Dioscorea (Yam) leaves 
    Zhou, Li; Shi, Xinmin; Ren, Xiangmei; Qin, Zhihong (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-09)
    This study was aimed to assess the potential of Dioscorea (yam) leaves as a source of antioxidants. Microwave-assisted extraction (MAE) process was used to prepare the extracts. The phenolic compounds in Dioscorea leaves ...
  • Inhibition of diet-restriction-induced behavioral deficits by tryptophan administration in rats 
    Darakhshan M Saleem; Shafaque Mehboob; Khan, Moona Mehboob; Noreen Samad; Afshan Zafar; Darakhshan J Haleem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-08)
    Diet has a great impact on brain health and function. It plays an important role to improve and control a number of psychiatric disorders such as depression, anxiety, hyperactivity and behavioral impulsivity. Anorexia ...
  • Study of biological activity and targeted distribution of catesbeianalectin in mouse tissue 
    Zhao, Rui-Li; Lin Zhu; Liu, Meng-Yue; Jin, Tian-Ming; Ma, Ji-Fei; Hu, Ye; Wang, Xuan; Qin, Shun-Yi; Chen, Jian-Bao (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-07)
    Lectin has attracted attention because of its ability to serve as a carrier for targeted drug delivery. Large lectins isolated from marine invertebrates and crustaceans have strong immunogenicity and adverse effects, which ...
  • Microwave and conventional synthesis of Co (II), Cu (II) and Ni (II) metal complexes of some acid hydrazones with their spectral characterization and biological evaluation 
    Mussarat Jabeen; Karamat Mehmood; Khan, Misbah-ul Ain; Noreen Aslam; Ansa Madiha Zafar; Naveed Sajid; Shazia Noreen; Samina Aslam; Abdul Ghafoor (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-06)
    The transition metal complexes of Co(II), Ni(II), and Cu(II) derived from N'-((5-(2,5-dichlorophenyl)furan-2- yl)methylene)-2-hydroxybenzohydrazide (L24) and N'-((5-(2, 5-dichlorophenyl)furan-2-yl)methylene)benzohydrazide ...
  • Effects of Costus speciosus ethanolic extract on male rats: The action mechanism and the ability to impregnate 
    Sari, Ika Puspita; Nurrochmad, Arief; Setiawan, Irfan Muris; Hertiani, Triana; Paramita, Annisa Dian; Annisa, Anggit Yustitia (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-05)
    To examine the action mechanism that mediates the anti-fertility effect of Costus speciosus extract, research was conducted on male Sprague-Dawley rats. Costus extract was given to male rats for 14 days at various doses, ...
  • Ethanolic seeds extract of Centratherum anthelminticum reduces oxidative stress in type 2 diabetes 
    Hina Akram Mudassir; Shamim A Qureshi; Muhammad Bilal Azmi; Muhammad Ahsan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-05-04)
    This work was accomplished to assess the in-vitro antiglycation and antioxidant activities of ethanolic seeds extract of Centratherum anthelminticum (CSEt), followed by its in-vivo examination in type 2 diabetes. Overnight ...

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