Volume: Recent submissions

  • A comparative neurobehavioral study of sesame oil and fish oil on experimental animals 
    Naeem, Sadaf; Ali, Liaquat; Rizwani, Ghazala H; Ikram, Rahila; Khan, Saira Saeed; Shareef, Huma; Younus, Ishrat; Malick, Tabinda Zareen; Aleem, Umer (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Natural oils are enriched with polyunsaturated fatty acids (PUFAs) which are important for our health. Recent experimental data explained that PUFAs might have a beneficial effect on various brain functions such as anxiety, ...
  • Terpenoid-lupeol of red dragon fruit (Hylocereus polyrhizus) and its immunomodulatory activity 
    Wahdaningsih, Sri; Wahyuono, Subagus; Riyanto, Sugeng; Murwanti, Retno (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Red dragon fruit (Hylocereus polyrhizus, (F.A.C. Weber) Britton and Rose) has been reported to have various biological activities such as antimicrobial, anti-hypercholesterolemia, anti-diabetes mellitus, cardiovascular ...
  • Effectiveness of methotrexate in combination therapy in a rat collageninduced arthritis model 
    Zhuang, Chenchen; Zhou, Juan; Mo, Hailu; Lin, Dong; Luo, Xiaohong; Mo, Hanyou (2019-09-16)
    This study was to investigate the effect of methotrexate in combination therapy by the characteristic cytokine in Th17 cells and the frequency of Tregs, which involved in the induction and pathological progress of ...
  • Relaxant activity of different fractions of fruits of Rosa moschata J. 
    Nabi, Muhammad; Ali, Niaz; Shams, Bilal; Ahmed, Ghayour; Shah, Muhammad Jalat; Shakir Ullah; Shoaib, Mohammad; Shah, Syed Wadood Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    The current work is an attempt to know that in which fraction(s) the relaxant constituents of Rosa moschata concentrate. Crude methanolic extract of Rosa moschata was prepared as per our reported procedure. Sub fractions ...
  • Phytochemical, anti-inflammatory, anti-nociceptive and cytotoxic basis for the use of Haloxylon stocksii 
    Peerzada, Sohaib; Khan, Muhammad Tanveer; Akhtar, Muhammad Furqan; Saleem, Ammara; Hamid, Irfan; Sharif, Ali; Akhtar, Bushra; Ali, Sajid; Ahmed, Shoaib; Raza, Moosa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    A halophytic plant, Haloxylon stocksii, is used to treat various inflammatory disorders traditionally. The present study was carried out to investigate the phytochemical parameters, anti-inflammatory, analgesic and ...
  • Light transmission properties of pharmaceutical liquid bottles and evaluation of their photoprotective efficacy 
    Sabah, Arif; Shah, Ali; Tanwir, Sidra; Arsalan, Adeel; Malik, Aysha; Ahmad, Iqbal (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    The light sensitive pharmaceutical dosage forms are well protected from light by packing in light protective bottles especially the colored glass and plastic bottles. In the present study the transmission characteristics ...
  • Synthesis, characterization, antibacterial, hemolytic and thrombolytic activity evaluation of 5-(3-chlorophenyl)-2-((N-(substituted)-2- acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives 
    Aziz-ur-Rehman; Khan, Samreen Gul; Bokhari, Tanveer Hussain; Anjum, Fozia; Akhter, Naheed; Rasool, Shahid; Shah, Syed Adnan Ali; Shahid, Muhammad; Arshad, Aneesa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    A novel series of 5-(3-Chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives was efficiently synthesized and screened for antibacterial, hemolytic and thrombolytic activities. The molecule ...
  • Long term outcome of chronic myeloid leukemia patients treated with imatinib: Report from a developing country 
    Absar, Muhammad; Akhtar, Tanveer; Jameel, Abid; Mahmood, Amer; Ullah, Anhar; Aleem, Aamer; Qureshi, Kulsoom; Rehman, Noor; Iqbal, Zafar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    The outcome of chronic myeloid leukemia has been greatly improved by the use of Imatinib (IM), a selective BCR/ABL kinase inhibitor. The aim of present study was to report long term follow-up & outcome of IM-treated ...
  • Synthesis, characterization and antimicrobial activity of norfloxacin based acetohydrazides 
    Walayat, Kamran; Ahmad, Matloob; Rasul, Azhar; Aslam, Sana; Anjum, Muhammad Naveed; Sultan, Sadia; Iqbal, Mazhar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    The drug resistance phenomenon in microbes is resulting in the ineffectiveness of available drugs to treat the infections. Thus, there is a continued need to discover new molecules to combat the drug resistance ...
  • Assessment of reproductive disorder (imposex) induced by tributyltins in marine gastropods 
    Hassan, Safia; Siddiqui, Ghazala; Trudgett, Alan; Robert, David; Zhao, Yanyan; Wang, Xinhong (2019-09-15)
    Imposex is a genital disorder characterized by imposition of male sexual characteristics in female gastropods due to exposure to tributyltin (TBT). TBT is used as biocidal agent in antifouling paints, applied on the ship ...
  • Evaluation of wound healing effects of Syzygium cumini and laser treaqtment in diabetic rats 
    Kazmi, Syed Asif Jahanzeb; Riaz, Azra; Akhtar, Naheed; Khan, Rafeeq Alam (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    This study was aimed to investigate the antioxidant effects of Syzygium cumini (S. cumini) seeds extract along with wound healing score in correlation to glutathione and blood glucose levels in diabetic rats. Sprague-Dawley ...
  • Piroxicam loaded polymer hybrid microspheres based tablets with modified release kinetics: Development, characterization and in vivo evaluation 
    Hamid, Hajra Afeera; Khan, Shahzeb; Shah, Syed Muhammad Noor; Asghar, Muhammad; Shahid, Muhammad; Hussain, Zahid; Sohail, Muhammad; Barkat, Ali Khan; Amin, Fazli; Jan, Syed Umer; Elhissi, Abdelbary; Shah, Syed Muhammad Hassan; Minhas, Muhammad Usman; Shah, Syed Wadood Ali; Ahmad, Naveed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    Piroxicam (PC) is a non-steroidal anti-inflammatory drug characterized by poor aqueous solubility and reported to cause and impart crucial GIT irritation, bleeding, peptic and duodenal ulcer. Engineering of PC ...
  • Cardiotonic potential of Carissa opaca Stapf ex Haines: A study on isolated rabbit heart 
    Alqahtani, Yahya S; Amir, Huma; Alamgeer; Ahmad, Taseer; Mahnashi, Mater H; Alyami, Bandar A; Alqarni, Ali O; Akram, Muhammad; Khan, Hafeez Ullah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    : Carissa opaca (C.O) is a wild shrub, belonging to the family Apocynaceae. The medicinal virtues of this plant have long been known. The present study demonstrates the effects of aqueous-methanolic extract and various ...
  • Cardioprotective effect of boswellic acids against doxorubicin induced myocardial infarction in rats 
    Shahid, Muhammad Hassaan; Anjum, Irfan; Mushtaq, Muhammad Naveed; Riaz, Saba (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    The aim of the present study was to evaluate the cardioprotective activity of boswellic acids in doxorubicin (DOX) induced cardiotoxicity. DOX (2.5mg/kg) was used intraperitoneally in rats to induce cardiotoxicity in six ...
  • Synthesis and anticancer evaluation of 2-oxo-2-(arylamino) ethyl 4- phenylpiperazine-1-carbodithioates 
    Hafeez, Freeha; Zahoor, Ameer Fawad; Rasul, Azhar; Ahmad, Sajjad; Mansha, Asim (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    Piperazine moiety is found as an efficient pharmacological scaffold in various drugs. To explore the anticancer potential of piperazine framework, a series of novel N-acetamides derivatives of phenyl piperazine ...
  • Immunoinformatics approaches to explore B and T cell epitope-based vaccine designing for SARS-CoV-2 Virus 
    Bashir, Zohaib; Ahmad, Syed Umair; Kiani, Bushra Hafeez; Jan, Zainab; Khan, Nayab; Khan, Umama; Ihteshamul Haq; Zahir, Fazli; Qadus, Amara; Mahmood, Tariq (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    SARS-CoV-2, a new world coronavirus belonging to class Nidovirales of Coronaviridae family causes COVID-19 infection which is the leading cause of death worldwide. Currently there are no approved drugs and vaccines available ...
  • Potential therapeutic effects of avenanthramide-C against lung toxicity caused by silver nanoparticles injection in rats 
    Altwaijry, Najla; El-Masry, Thanaa A; Alotaibi, Badriyah S; Tousson, Ehab; Alodhayani, Abdulaziz A; El-Morshedy, Kadreya; Elmaghed, Nouf A; Sayed, Ahmed E; Saleh, Asmaa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    : Most clinical investigations about the impact of nanoparticles on cells and tissues show that nanoparticles may enter the human body by means of respiratory tracts. Humans, animals, plants and environments are ...
  • Less disease severity of COVID-19 among smokers: An indication of investigating nicotine as preventive measure 
    Ghayyur, Aysha; Hussain, Syed Shahzad; Salam, Emaan; Saeed, Subhan; Shahid, Saman; Tanvir Us Salaam (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    The study was aimed to mention the epidemiology of smoking in Pakistani COVID-19 infected patients along with the disease severity, oxygen dependency and fatality rate. A cross sectional epidemiological study was carried ...
  • Oral bioavailability studies of niosomal formulations of Cyclosporine A in albino rabbits 
    Mujeeb Ur Rehman; Rasul, Akhtar; Khan, Muhammad Imran; Rasool, Maria; Abbas, Ghulam; Masood, Feroza; Nazir, Imran; Iqbal, Muhammad; Islam, Nayyer; Hameed, Misbah; Shah, Pervaiz Akhtar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    Cyclosporine A (CsA) is an immunosuppressant agent. Two niosomal formulations of CsA, FTS and FSB were formulated. Both formulations were studied in terms of size, polydispersity index (PDI), morphology and entrapment efficacy ...
  • Hepatoprotective and hypolipidemic activities of Caesalpinia bonduc seed kernels and Gymnema sylvestre leaves extracts in alloxan-induced diabetic rats 
    Kousar, Shaneel; Aslam, Bilal; Muhammad, Faqir; Khan, Junaid Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    The objective of the current research was to validate the hepatoprotective and anti-hyperlipidemic activities of C. bonduc seed kernels (CBSK) and G. sylvestre leaves (GSL) hydro-methanolic extracts, separately and in ...

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