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Browsing Issues by Title

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  • Less disease severity of COVID-19 among smokers: An indication of investigating nicotine as preventive measure 
    Ghayyur, Aysha; Hussain, Syed Shahzad; Salam, Emaan; Saeed, Subhan; Shahid, Saman; Tanvir Us Salaam (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    The study was aimed to mention the epidemiology of smoking in Pakistani COVID-19 infected patients along with the disease severity, oxygen dependency and fatality rate. A cross sectional epidemiological study was carried ...
  • The mouse model of hepatic veno-occlusive disease 
    An, Licai; Li, Xijing; Chu, Xiaoxia; Liu, Xiaoqian; Zhang, Yuanfeng; Wang, Yanming; Wang, Yan; Liu, Yinghui (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2021-11-02)
    With the application of hematopoietic stem cell transplantation, Subacute or acute increase in the incidence of hepatic veno-occlusive disease (HVOD) becomes more common and it can lead to fatal complications. This article ...
  • Nanobiotechnology: Cradle for revolution in drug carrier systems 
    Zafar, Saba; Rasul, Akhtar; Iqbal, Muhammad Shahid; Rasool, Maria; Ahmed, Bilal; Qadir, Muhammad Imran (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    : The role of nanobiotechnology in the treatment of diseases is limitless. In this review we tried to focus main aspects of nanotechnology in drug carrier systems for treatment and diagnosis of various diseases such as ...
  • Neurochemical and behavioral effects of lorazepam: A dose related study 
    Ikram, Huma; Atique, Iqra; Perveen, Shahla; Zakir, Rumaisa; Haleem, Darakhshan J (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    Present study was designed to monitor the dose dependent effects of lorazepam; a benzodiazepine (CNS depressant). It is the primary drug of choice for treatment of anxiety and to produce calming effects. However, ...
  • Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka 
    Hassan, Ibrahim Maina; Ibrahim, Wan Norhamidah Wan; Yusuf, Ferdaus Mohamat; Ahmad, Siti Aqlima; Ahmad, Syahida (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    Diseases caused by oxidative stress can be prevented by antioxidant. Current treatments for those neurodegenerative diseases are not effective and cause many side effects. Thus, the search for alternative medicines is ...
  • Neuroprotective role of a monoterpene (thymol) on diazepam induced withdrawal symptoms in rats 
    Saleem, Sadia; Naqvi, Fizza; Batool, Asma; Naqvi, Sajjad Haider; Naqvi, Faizan; Batool, Zehra; Tabassum, Saiqa; Haider, Saida (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)
    : Benzodiazepine administration is known to be related to tolerance and a withdrawal syndrome on sudden cessation. Thymol possesses multiple biological properties especially in the pathogenesis of different brain ...
  • New series of hydrazinyl thiazole derivatives of piperidin-4-one: Synthesis, structural elucidation, analgesic activity and comparative structure activity relationship 
    siddiqui, Rubina; Akhter, Shamim; Haider, Shazia; Saify, Zafar Saied; Akhtar, Mahwish; Shamim, Sana (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)
    Seven new hydrazinyl thiazole derivatives of piperidin-4-one (PE3-PE9) have been synthesized by cyclization of intermediate thiosemicarbazone derivative (PE2). Parent molecule (PE1) was synthesized by one pot total ...
  • Optimization of chitosan for microencapsulation of flaxseed oil through spray drying 
    Kanwal, Sidra; Hafeez-ur-Rahman, Muhammad; Hussain, Ali; Nadeem, Muhammad; Abbas, Farzana; Akram, Muhammad; Inayat, Muhammad; Ali, Kashif (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)
    The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods. Four formulations ...
  • Optimization of empagliflozin immediate release tablets (10 mg) using central composite rotatable design with response surface methodology 
    M. Hanif, Anas; Bushra, Rabia; Iffat, Wajiha; Ghayas, Sana; Perveen, Shaheen; Riaz, Humayun; Alam, Shazia; Ali, Syed Imran; Ismail, Nahlah Elkudssiah; Zeb-un-Nisa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)
    Empagliflozin is a selective inhibitor of sodium glucose co-transporter II, given as mono therapy or an add-on treatment to reduce the glycated hemoglobin levels in type 2 diabetes. This work deals with designing, formulating ...
  • The optimization of total flavonoids from rhizoma drynariae by response surface methodology and the metal ion chelation activity assay 
    Guan, Li; Huang, Xingyu; Zhao, Huiru; Li, Weize (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2021-03-18)
    Rhizoma Drynariae, the dried rhizome of Drynaria fortunei (Kunze), is rich in flavonoids and has varieties of pharmacological activities. To optimize the extract conditions for bioactive flavonoids, a response surface ...
  • Oral bioavailability studies of niosomal formulations of Cyclosporine A in albino rabbits 
    Mujeeb Ur Rehman; Rasul, Akhtar; Khan, Muhammad Imran; Rasool, Maria; Abbas, Ghulam; Masood, Feroza; Nazir, Imran; Iqbal, Muhammad; Islam, Nayyer; Hameed, Misbah; Shah, Pervaiz Akhtar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    Cyclosporine A (CsA) is an immunosuppressant agent. Two niosomal formulations of CsA, FTS and FSB were formulated. Both formulations were studied in terms of size, polydispersity index (PDI), morphology and entrapment efficacy ...
  • Pharmacognostic screening, physico-chemical and cytotoxic potential of Sesuvium sesuvioides (Fenzyl) Verdc 
    Sajid-ur-Rehman, M.; Ishtiaq, Saiqa; Khalil-ur-Rehman, Muhammad; Bauer, Rudolf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)
    Sesuvium sesuvioides(Fenzl) Verdc. (Aizoaceae) is commonly known as BarriUlwaiti and used in folklore remedies; i.e. arthritis, gout, epistaxis, hemorrhage, smallpox, chickenpox, cold and flu by the local practitioners ...
  • Pharmacological basis for the antihypertensive activity of Grewia asiatica fruit extract 
    akram, zuneera; Perveen, Rehana; Siddiqi, Hasan Salman; Hussain, Muzammil; Imam, Shahlla; Abrar, Hina; Mahmood, Syed Mohammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)
    In the management of cardiovascular disorders, medicines from herbal sources have played a vital role through centuries. The following study was commenced in order to lay possible pharmacological foundation associated with ...
  • Phenotypic and molecular characterization of virulence factors of extra-intestinal pathogenic Escherichia coli isolated from patients of Peshawar, Pakistan 
    Zeb, Zermina; Azam, Sadiq; Rehman, Noor; Khan, Ibrar; Afzal, Sumera; Gul-e-Sehra; Anhar Ullah; Absar, Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    Extra-Intestinal Escherichia coli (ExPEC) are important cause of Urinary Tract Infections (UTIs) and systemic infections. The purpose of this study was to investigate numerous ExPEC bacterial isolates for phenotypic virulence ...
  • Phytochemical screening and biological activities of Bromus pectinatus Thunb 
    Begum, Kausar; Abbas, Saira; Mushtaq, Nadia; Khan, Saad Ullah; Parveen, Ishrat; Jamil ur Rahman, H.; Mahmood, Sultan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    The present research study investigates the phytochemical and pharmacological importance of Bromus pectinatus. Qualitative phytochemical analysis of this plant was carried out to use standard method for the presence ...
  • Phytochemistry, antioxidant and antibacterial activities of fruit extracts of Myrsine africana L. 
    Gul, Hina; Kaukab Raja, Ghazala; Shahid, Maryam; Iqbal, Mohsin; Irum, Samra; Agshar, Arafa; Ahmad, Dawood; Gulfraz, Muhammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2021-03-03)
    Myrsine africana L. a commonly consumed medicinal plant grows in forest of mountains region located at North East of Pakistan. In current study, the fruit extracts were chemically characterized and their bioactivities were ...
  • Piroxicam loaded polymer hybrid microspheres based tablets with modified release kinetics: Development, characterization and in vivo evaluation 
    Hamid, Hajra Afeera; Khan, Shahzeb; Shah, Syed Muhammad Noor; Asghar, Muhammad; Shahid, Muhammad; Hussain, Zahid; Sohail, Muhammad; Barkat, Ali Khan; Amin, Fazli; Jan, Syed Umer; Elhissi, Abdelbary; Shah, Syed Muhammad Hassan; Minhas, Muhammad Usman; Shah, Syed Wadood Ali; Ahmad, Naveed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    Piroxicam (PC) is a non-steroidal anti-inflammatory drug characterized by poor aqueous solubility and reported to cause and impart crucial GIT irritation, bleeding, peptic and duodenal ulcer. Engineering of PC ...
  • Plasma ApoA-1 and endothelin-1 levels changes in early Parkinson disease and its relationship with cognitive function and cerebral white matter structure change 
    Yan, Yingying; Fu, Jianjiong (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    The study aimed to investigate the plasma apolipoprotein A-1 (ApoA-1) and endothelin -1 (ET-1) changes in early Parkinson disease (PD), and analyze their relationship with cognitive function and cerebral white matter ...
  • Potential protective role of curcumin powder to regulate arsenicinduced hepatorenal toxicity and hyperlipidemic metabolic dysfunction in rat model 
    Haleem, Muhammad Ammar; Khan, Safwan Ahmad; Khan, Muhammad Kamran; Ahmad, Rabia Shabir; Naqvi, Syed Ali Raza; Imran, Muhammad; Ahmed, Muhammad Haseeb; Anwar, Haseeb; Mahr Un Nisa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)
    The present work was conceptualized to determine the potential protective effects of curcumin on arsenicinduced kidney damage in male albino rat model. Thirty six male albino rats were selected, weighed about 175±10g ...
  • Potential therapeutic effects of avenanthramide-C against lung toxicity caused by silver nanoparticles injection in rats 
    Altwaijry, Najla; El-Masry, Thanaa A; Alotaibi, Badriyah S; Tousson, Ehab; Alodhayani, Abdulaziz A; El-Morshedy, Kadreya; Elmaghed, Nouf A; Sayed, Ahmed E; Saleh, Asmaa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-01-16)
    : Most clinical investigations about the impact of nanoparticles on cells and tissues show that nanoparticles may enter the human body by means of respiratory tracts. Humans, animals, plants and environments are ...

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