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Recent submissions

Issue 4: Recent submissions

Now showing items 1-20 of 23

Insights into Off-Label therapeutic strategies against mild and severe COVID-19 infection

Arshad, Bushra; Iqbal, Tahira; Bhatti, Khalid Pervez; Ahmed, Sheraz; Zaman, Wajid; Fazal Ullah; Nazeer, Amna; Saqib, Saddam (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Currently, prevention and control of the coronavirus disease pneumonia epidemic situation are grim globally. To cope with total sheer carriers and patients of COVID-19 requires intensive medical support and adjunctive ...
Clinical outcomes of using second – versus first-Generation EGFR-tkis for the First-Line treatment of advanced NSCLC patients with EGFR mutations: A meta-analysis

Hou, Bing; Lu, Xiao; Gao, Dong-Cai; Liu, Quan-Xing; Zhou, Dong; Zheng, Hong; Dai, Ji-Gang (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

First-generation EGFR-TKIs (gefitinib/erlotinib) and second-generation EGFR-TKI (afatinib) have become the current first-line treatments for EGFR-mutated non-small cell lung cancer (NSCLC), however, the effects of ...
Atractylenolide II induces cell cycle arrest and apoptosis in breast cancer cells through ER pathway

Dou, Shaohua; Yang, Chao; Zou, Danfeng; Da, Wa; Masood, Muqaddas; Adlat, Salah; Baima, Yang-Jin; Nasser, MI; Li, Bin; Jiang, Nan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

In this research, atractylenolide II (ATR II) on apoptosis, cell cycle cells via ER pathway in breast cancer (MDA-MB-231 and MCF-7) cells are assessed. The effect of ATR II on cell proliferation was detected by MTT assay. ...
Anti-inflammatory and anti-nociceptive activities of polyphenols from Feijoa fruit and leaves

Mahmoudi, Mitra; Seif, Sadaf; Khan, Barkat Ali; Alshahrani, Sultan M; Arimi, Amirali; Allami, Alireza; Alqahtani, Saad S.; Ebrahimzadeh, Mohammad Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Many pharmacological activities have been reported from plants polyphenols. The aim of this study was to investigate anti inflammatory and antinociceptive activities of polyphenols from Feijoa sellowiana fruit and leaves. ...
Application of factorial experimental design for optimization and development of color lipstick containing antioxidant-rich Sacha inchi oil

Poomanee, Worrapan; Kongin, Kultida; Sriputorn, Kemjira; Leelapornpisid, Pimporn (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

This study aimed to optimize and develop the color lipstick formulation containing antioxidant-rich Thai Sacha inchi oil using full factorial experimental design. Antioxidant capacity of Sacha inchi oil was elucidated ...
Pharmacological basis for the antihypertensive activity of Grewia asiatica fruit extract

akram, zuneera; Perveen, Rehana; Siddiqi, Hasan Salman; Hussain, Muzammil; Imam, Shahlla; Abrar, Hina; Mahmood, Syed Mohammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

In the management of cardiovascular disorders, medicines from herbal sources have played a vital role through centuries. The following study was commenced in order to lay possible pharmacological foundation associated with ...
Isolation, identification, and antimycotic activity of plumbagin from Plumbago europaea L. roots, leaves and stems

Jaradat, Nidal; Khasat, Ahmad Ibrahim; Al-Maharik, Nawaf; M Eid, Ahmad; Jundi, Waheed; Zatar, Nidal Abd Aljaber; Shtayeh, Mohammed Saleem Ali; Jamous, Rana (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Plumbago europaea L. is a plant utilized in Palestinian ethnomedicine for the treatment of various dermatological diseases. The current investigation was designed to isolate plumbagin from P. europaea leaves, roots and for ...
New series of hydrazinyl thiazole derivatives of piperidin-4-one: Synthesis, structural elucidation, analgesic activity and comparative structure activity relationship

siddiqui, Rubina; Akhter, Shamim; Haider, Shazia; Saify, Zafar Saied; Akhtar, Mahwish; Shamim, Sana (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Seven new hydrazinyl thiazole derivatives of piperidin-4-one (PE3-PE9) have been synthesized by cyclization of intermediate thiosemicarbazone derivative (PE2). Parent molecule (PE1) was synthesized by one pot total ...
Effect of vasopressin on electrocardiographic changes produced by ischemia-reperfusion in rats

Nazari, Afshin; Mohamadi, Asghar; Imani, Ali Reza; Faghihi, Mahdieh; Tarahi, Mohamad Javad; Moghimian, Maryam; Cheraghi, Mostafa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

The present study was conducted to identify the effect of vasopressin (AVP) on electrocardiographic changes produced by ischemia-reperfusion . Male rats were divided into seven groups (n=8-13) subjected to 30min ischemia ...
Synthesis and cytotoxicity evaluation of alpha beta unsaturated carboxylic acids of thiophene analogs by using polymer supported microwave-assisted method

Hassan, Jhanara; Ehsan, Shahana; Shahnaz; Khan, Tahira Moen; Saghir, Tahira (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

α- β unsaturated carboxylic acids containing a heterocyclic moiety is one of the most potent class of bioactive compounds whose speedy generation through novel synthetic techniques has become an enigma for the ...
Isolation of new phytometabolites from Alpinia galanga willd rhizomes

Sharma, Pradeep Kumar; Fuloria, Shivkanya; Ali, Mohammed; Singh, Amit; Kushwaha, Shekhar Prakash; Sharma, Vijay Kumar; Subramaniyan, Vetriselvan; Fuloria, Neeraj Kumar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

The current research was aimed to isolate newer phyto-metabolites from rhizomes of Alpinia galanga plant. Study involved preparation of Alpinia galanga rhizome methanolic extract, followed by normal phase column chromatography ...
The effects of alendronate treatment in the diagnosis and management of proximal femur osteoporosis: A real-life scenario

Asadullah, Muhammad; Sarfaraz, Sana; Tanzil, Sana; Ikram, Rahela; Kamil, Noor (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Currently the increased focus is being given to reforming osteoporosis regimens. Optimizing the evaluation of pharmacological intervention occurs once a medicine has been approved. There is literature available on the use ...
Evaluation of wound healing potential and biochemical estimation of sage oil nanoemulsion on animal model

Alam, Muhammad Sarfaraz; Ali, Mohammad Daud; Ahmad, Sarfaraz; Banu, Nuzhat; Ali, Muhammad Sajid; Alam, Nawazish; Ali, Muhammad; Ansari, Muhammad Salahuddin; Shamim, Muhammad; Mujtaba, Muhammad Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

The study was aimed to design a nano emulsion formulations of Sage oil and to determine its effectiveness in healing the wound using rats as a model. Sage oil nanoemulsion (o/w) was formulated by a spontaneous ...
Allantoin may modulate aging impairments, symptoms and cancers

Marzook, Fawzy; Marzook, Ebtisam; El-Sonbaty, Sawsan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Allantoin increases in different stress conditions and environment such as physical activity, amniotic fluids and oxidative stress. So, we inspired to explore the role of allantoin as a metabolic by-product in health ...
Analgesic and anti-inflammatory potential of four varieties of bell pepper (Capsicum annum L.) in rodents

Mazha, Nimra; Baig, Sadia Ghousia; Ahmed, Salman; Mohtasheem ul Hasan, Mohammad; Palla, Amber; Ishra, Ghazala (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

The aim of study was to evaluate the analgesic and anti-inflammatory activity of four different colored (green, yellow, orange and red) sweet bell peppers (Capsicum annuum L.) available in the local market of Karachi ...
Comparative proteome-wide study for in-silico identification and characterization of indispensable hypothetical proteins of food bornepathogen Campylobacter jejuni (CJJ) by subtractive genomics approach

Reaz Uddin; Arif, Alina; Zahra, Noor-ul-Ain; Sufian, Muhammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Campylobacter jejuni (CJJ) is a source of bacterial foodborne diarrhea globally. Mostly found prevalent in children in the developing countries that may lead to mortality. The upsurge in antimicrobial resistance is ...
Effects of Yupingfeng nasal drops on serum cytokines, histopathology and eosinophil cationic protein in nasal mucosa of rats with allergic rhinitis

Liu, Bao; Huang, Xiangming; Xia, Lina; Wang, Dandan; Mu, Dehong; Tian, Li (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Allergic rhinitis (AR) is one of the most common atopic disorders, which seriously affects patients' quality of life. Yupingfeng (YPF) Power is a traditional Chinese herb formula, and its oral dosage form has been widely ...
Protective role of lycopene on blood haematology parameters in liver cirrhosis: Study in rats

Zaidi, Syeda Nuzhat Fatima; Iqbal, Iqra SM (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

The present study was designed to evaluate the effect of lycopene supplementation on blood haematology parameters in thioacetamide induced liver cirrhosis. Experimental period consisted of 12 weeks, divided into two ...
Purification and characterization of β-galactosidase from Aspergillus fumigatus PCSIR-2013

Bano, Saeeda; Iqbal, Samina; Siddiqui, Kausar; Abbasi, Kanwal (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Extra cellular β-galactosidase enzyme was purified and characterized from Aspergillus fumigatus PCSIR2013. Estimated molecular mass of the enzyme was approximately 95 kDa. by native polyacrylamide gel electrophoresis. Initially, ...
Enteric coating of nanostructured lipid carriers (NLCs) and enteric coating of hard gelatin capsules filled with NLCs: Feasibility studies

Managuli, Renuka Suresh; Reddy, Meka Sreenivasa; Koteshwara, Kunnatur Balasundara; Mutalik, Srinivas (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2021-07-20)

Nanostructured lipid carriers (NLCs) of asenapine maleate (ASPM) were enteric coated with polymethacrylate polymers (Eudragit®) for oral delivery. The present study aimed to compare the feasibility of direct enteric coating ...

Now showing items 1-20 of 23

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