• CYP2D6*4 null allele frequency in sixteen Pakistani ethnic groups 

  Anwar Ullah; Riaz, Sana; Siddiqi, Saima; Mazhar, Kehkashan; Mansoor, Atika (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  : CYP2D6 belongs to a family of Cytochrome P450 and is involved in metabolism of a number of commonly prescribed drugs. This study was designed to identify *4 allelic frequency of CYP2D6 in Pakistani population. ...
• Molecular docking and in-silico study of natural antagonists of ERalpha receptor: Potential candidates against breast cancer 

  Ahmed, Bilal; Qadir, Muhammad Imran; Hafiza Noor-ul-Ain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Breast cancer is affecting the women in both developing and non-developing countries in a dangerous ratio. Estrogen receptor alpha (ER-α) controls a number of physiological processes. Its over expression is seen in breast ...
• Therapeutic effects of Rhamnus alaternus on the nephroangiosclerosis in wistar rats 

  Halzoune, Hanane; Saiah, Wassila; Tabani, Khadija; Lahfa, Farid; Koceir, Elhadj Ahmed; Omari, Naima (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  The buckthorn “Rhamnus alaternus” is a plant used in traditional medicine especially in the treatment of certain diseases such as diabetes, cardiovascular disease and dyslipidemia. The aim of our study was to analysed ...
• In-silico determination of pKa and logp values of some isoniazid synthetic analogues using Marvin software 

  Naeem, Sabahat; Akhtar, Shamim; Zafar, Shaista; Iqbal, Sadia (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  : Among the physicochemical properties, pKa and LogP values help us in studying drug parameters like ADME and could be predicted to some extent. With this view, here we wish to predict these two properties of our ...
• Synthesis and characterization of Schiff base of nicotinic hydrazide as antibacterial agent along with in vivo wound healing activities and atomic force microscopic study of bacterial cell wall affected by synthesized compound 

  Barki, Samiullah; Barki, Zeba Gul; Haider, Shazia; Mehjabeen; Ijaz Ahmed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-02-16)

  The present work reports the synthesis of Schiff base series of nicotinic hydrazide (C-1-C-5) and it’s antibacterial and wound healing evaluation. The synthetic molecules were characterized with different spectroscopic ...
• A validated RP-HPLC method for the determination of piperidone analogue of curcumin 

  Alomrani, Abdullah; Alhabardi, Samiah; Aboussekhra, Abdelilah; Alshamsan, Aws; Attia, Mohamed I; Al Quadeib, Bushra (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Curcumin (Diferuloylmethane) is a natural product extracted from the root of Curcuma longa. 5-Bis (4- hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidone, the piperidone analogue of curcumin (PAC), was one of the analogues ...
• Evaluation of antioxidant and antimicrobial activities on various extracts of Himalayan medicinal plants 

  Ali, Mumtaz; Abdul Latif; Najeeb ur Rehman; Zaman, Khair; Mehsud, Saifullah; Akbar, Nazia; Ahmad, Manzoor; Arfan, Mohammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  The DPPH radical scavenging potentials of the fractions were determined in comparison to positive controls such as quercetin with EC50 = 4.12±1.27, ascorbic acid with EC50 = 6.20±1.67, gallic acid with EC50 = 4.75±1.24 ...
• Novel delivery based anionic linear globular dendrimerg2-zidovudine nano-conjugate significantly decreased retroviral activity 

  Pargoo, Esmaeel Mohammadi; Aghasadegh, Mohammad Reza; Parivar, Kazem; Bolhassani, Azam; Nikbin, Mehri; Rahimi, Pooneh; Ardestani, Mehdi Shafiee (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Human diseases like viral organisms for example, hepatitis, HIV and etc., attack the health and caused large mortality in populations by many years. So finding novel delivery vehicles based antiviral drugs employing ...
• Analysis of chemical constituents in the extract and rat serum from the chloroform extract of Oxytropis falcata Bunge by HPLC-MS 

  Zhang, Dejun; Yuan, Wangtao; Zhang, Benyin; Hong, Eun-Kyung; Shi, Ping; Yang, Zhanting; Zhang, Yuhao; Wang, Honglun (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Analysis of the constituents of the chloroform extract of Oxytropis falcata Bunge (CEOF), a traditional Tibetan medicine, in rat’s serum after oral administration, has been performed by HPLC-MS. We have identified ...
• Molecular docking, synthesis and biological evaluation of phenacyl derivatives of 9-aminoacridine as anti-Alzheimer’s agent 

  Munawar, Rabya; Mushtaq, Nousheen; Ahmed, Ahsaan; Saeed, Syed Muhammad Ghufran; Usmani, Saman; Akhter, Shamim; saify, ZS; Arif, Muhammad; Akram, Arifa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder mainly characterized by progressive deterioration of memory and impaired cognitive function. The most promising approach for symptomatic relief of ...
• Protective effect of Cnidoscolus aconitifolius leaves against diclofenacinduced gastric mucosal damage 

  Olivia, Njoku Ugochi; Happiness, Uzoagulu Chinedu; Obinna, Ogugofor Martins (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Cnidoscolus aconitifolius is one of the plants used in folk medicine for the treatment of peptic ulcer. However, the present study was designed to validate the gastro-protective effect of Cnidoscolus aconitifolius leaves ...
• Development of herbal formulation of medicinal plants and determination of its antihyperuricemic potential in vitro and in vivo rat’s model 

  Bilal, Muhammad; Ahmad, Saeed; Rehman, Tayyeba; Abbasi, Waheed Mumtaz; Ghauri, Aymen Owais; Arshad, Muhammad Adeel; Ayaz, Sultan; Nawaz, Allah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Hyperuricemia is a common metabolic disorder and several herbal formulations are being used for its treatment. The study aimed to develop herbal formulation (Urinil B) and find its hypouricemic effects in vitro and in vivo. ...
• Intestinal lymphatic transport study of antitumor lead compound T-OA with liposomes 

  Li, Shiyuan; Jin, Su; Wang, Xiuli; Song, Naiqi; Wang, Penglong; Chen, Fangning; Lei, Xiaoqing; Li, Geng (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Intestinal lymphatic transport has been proved to have contribution to oral absorption of some highly lipophilic drugs. T-OA, 3βhydroxyolea-12-en-28-oic acid-3,5,6-trimethylpyrazin-2-methylester, has been reported to have ...
• Antibacterial activity of the crude extracts from medicinally important Thuja occidentalis 

  Bakht, Jehan; Zafar, Zobia; Ahmad, Jawad; Khan, Shehla (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  The present research was carried out at the Institute of Biotechnology and Genetic Engineering, The University of Agriculture Peshawar, KPK Pakistan. In this study crude methanolic extracts from Thuja occidentalis ...
• Preparation of Uracil by bacteria isolated from Morchella 

  Fu, Shaobin; Ye, Zhang; Yang, Cailing; Meng, Qingfeng (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Morchella is one of the most famous rare edible and medicinal fungi over the world. Highly nutritious and immature cultivation techniques led to the high price and the markets have remained tight. The pathogenic bacteria ...
• Evaluation of anti-inflammatory and antibacterial potential of newly synthesized 4-(2-Keto-1-benzimidazollinyl) derivatives of piperidine 

  Leghari, Qurratul-ain; Vaid, Faiyaz HM; Saify, Zafar Saeid; Jabeen, Almas; Haider, Fouzia; Siddiqui, Rubina; Munawar, Rabya (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Benzimidazole and its derivatives found variety of biological activities, for the searching of its potent antiinflammatory analogues, we synthesized four novel 4-(2-keto-1-benzimidazollinyl) piperidine derivatives (Q1 to ...
• Effect of nose sensitive pill (NSP) on serum IFN-γ and il-4 levels in allergic rhinitis using rats model 

  Song, Zhongyun; Tu, Chunmei; Wang, Yongfu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  This study was conducted to investigate the changes of serum interleukin-4 (IL-4), interferon-γ (IFN-γ), interleukin-17 (IL-17) and interleukin-10 (IL-10) in allergic rhinitis model rats after using the traditional Chinese ...
• Vitamin D receptor FokI polymorphism in a Pakistani population with type 2 diabetes mellitus 

  Abdul Sattar, Naila; Hussain, Fatma (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Present research was undertaken with the aim to assess the association of VDR gene FokI polymorphism with T2DM in local population. The study comprised of 100 T2DM patients (DG) and 50 normal individuals (CG) groups. Demographic ...
• Protective effects of rutin on kidney in type 1 diabetic mice 

  Gong, Biao; Gou, Xiangbo; Han, Ting; Qi, Yajuan; Ji, Xiaoru; Bai, Jing (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  Diabetic nephropathy is one the most serious diabetic microangiopathies, which is the main cause of mortality in diabetic patients. Our research investigated the protective effects of rutin on kidney of the type 1 ...
• In vitro antioxidant and inhibitory activities of polyphenolic-rich extracts of Syzygium cumini (Linn) Skeels leaf on two important enzymes relevant to type II diabetes mellitus 

  Ajiboye, Basiru Olaitan; Ojo, Oluwafemi Adeleke; Oyinloye, Babatunji Emmanuel; Akuboh, Olivia; Okesola, Mary Abiola; Idowu, Olajumoke; Kappo, Abidemi Paul (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)

  In this study, the effect of free and bound polyphenolic-rich extract of Syzygium cumini (Linn) Skeels leaf on antioxidant as well as α-amylase and α-glucosidase activities were determined using in vitro model. ...

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