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Browsing Issue 2 by Issue Date

Browsing Issue 2 by Issue Date

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  • Synthesis of (4R)-thiazolidine carboxylic acid and evaluation of antioxidant potential 
    Begum, Nasreen; Anis, Itrat; Saeed, Syed Muhammad Ghufran; Ashraf, Seema; Choudhary, M. Iqbal (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    We report here the synthesis as well as antioxidant activity of a series of 2-aryl thiazolidine-4-carboxylic acids, including two novel derivatives. They were synthesized by nucleophilic cyclic condensation of ...
  • Hematological complications under hyper conditions of glucose and distilled water 
    Hafeez Ullah; Akhtar, Munir; Hussain, Fayyaz; Ahmad, Ejaz; Ahmad, Mukhtar; Aziz, Muhammad Hammad; Andleeb, Farah; Batool, Zahida (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    This work presents a pilot method of hematological diagnosis about changes in: shape, size and rouleaux formation, cell count of leucocytes and platelet cells in the presence of different glucose [C6H12O6] and water ...
  • Therapeutic effects of Rhamnus alaternus on the nephroangiosclerosis in wistar rats 
    Halzoune, Hanane; Saiah, Wassila; Tabani, Khadija; Lahfa, Farid; Koceir, Elhadj Ahmed; Omari, Naima (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    The buckthorn “Rhamnus alaternus” is a plant used in traditional medicine especially in the treatment of certain diseases such as diabetes, cardiovascular disease and dyslipidemia. The aim of our study was to analysed ...
  • A validated RP-HPLC method for the determination of piperidone analogue of curcumin 
    Alomrani, Abdullah; Alhabardi, Samiah; Aboussekhra, Abdelilah; Alshamsan, Aws; Attia, Mohamed I; Al Quadeib, Bushra (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Curcumin (Diferuloylmethane) is a natural product extracted from the root of Curcuma longa. 5-Bis (4- hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidone, the piperidone analogue of curcumin (PAC), was one of the analogues ...
  • Intestinal lymphatic transport study of antitumor lead compound T-OA with liposomes 
    Li, Shiyuan; Jin, Su; Wang, Xiuli; Song, Naiqi; Wang, Penglong; Chen, Fangning; Lei, Xiaoqing; Li, Geng (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Intestinal lymphatic transport has been proved to have contribution to oral absorption of some highly lipophilic drugs. T-OA, 3βhydroxyolea-12-en-28-oic acid-3,5,6-trimethylpyrazin-2-methylester, has been reported to have ...
  • Evaluation of antioxidant and antimicrobial activities on various extracts of Himalayan medicinal plants 
    Ali, Mumtaz; Abdul Latif; Najeeb ur Rehman; Zaman, Khair; Mehsud, Saifullah; Akbar, Nazia; Ahmad, Manzoor; Arfan, Mohammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    The DPPH radical scavenging potentials of the fractions were determined in comparison to positive controls such as quercetin with EC50 = 4.12±1.27, ascorbic acid with EC50 = 6.20±1.67, gallic acid with EC50 = 4.75±1.24 ...
  • Novel delivery based anionic linear globular dendrimerg2-zidovudine nano-conjugate significantly decreased retroviral activity 
    Pargoo, Esmaeel Mohammadi; Aghasadegh, Mohammad Reza; Parivar, Kazem; Bolhassani, Azam; Nikbin, Mehri; Rahimi, Pooneh; Ardestani, Mehdi Shafiee (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Human diseases like viral organisms for example, hepatitis, HIV and etc., attack the health and caused large mortality in populations by many years. So finding novel delivery vehicles based antiviral drugs employing ...
  • Effect of nose sensitive pill (NSP) on serum IFN-γ and il-4 levels in allergic rhinitis using rats model 
    Song, Zhongyun; Tu, Chunmei; Wang, Yongfu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    This study was conducted to investigate the changes of serum interleukin-4 (IL-4), interferon-γ (IFN-γ), interleukin-17 (IL-17) and interleukin-10 (IL-10) in allergic rhinitis model rats after using the traditional Chinese ...
  • CYP2D6*4 null allele frequency in sixteen Pakistani ethnic groups 
    Anwar Ullah; Riaz, Sana; Siddiqi, Saima; Mazhar, Kehkashan; Mansoor, Atika (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    : CYP2D6 belongs to a family of Cytochrome P450 and is involved in metabolism of a number of commonly prescribed drugs. This study was designed to identify *4 allelic frequency of CYP2D6 in Pakistani population. ...
  • Molecular docking, synthesis and biological evaluation of phenacyl derivatives of 9-aminoacridine as anti-Alzheimer’s agent 
    Munawar, Rabya; Mushtaq, Nousheen; Ahmed, Ahsaan; Saeed, Syed Muhammad Ghufran; Usmani, Saman; Akhter, Shamim; saify, ZS; Arif, Muhammad; Akram, Arifa (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder mainly characterized by progressive deterioration of memory and impaired cognitive function. The most promising approach for symptomatic relief of ...
  • Development of herbal formulation of medicinal plants and determination of its antihyperuricemic potential in vitro and in vivo rat’s model 
    Bilal, Muhammad; Ahmad, Saeed; Rehman, Tayyeba; Abbasi, Waheed Mumtaz; Ghauri, Aymen Owais; Arshad, Muhammad Adeel; Ayaz, Sultan; Nawaz, Allah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Hyperuricemia is a common metabolic disorder and several herbal formulations are being used for its treatment. The study aimed to develop herbal formulation (Urinil B) and find its hypouricemic effects in vitro and in vivo. ...
  • Protective effect of Cnidoscolus aconitifolius leaves against diclofenacinduced gastric mucosal damage 
    Olivia, Njoku Ugochi; Happiness, Uzoagulu Chinedu; Obinna, Ogugofor Martins (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Cnidoscolus aconitifolius is one of the plants used in folk medicine for the treatment of peptic ulcer. However, the present study was designed to validate the gastro-protective effect of Cnidoscolus aconitifolius leaves ...
  • Evaluation of anti-inflammatory and antibacterial potential of newly synthesized 4-(2-Keto-1-benzimidazollinyl) derivatives of piperidine 
    Leghari, Qurratul-ain; Vaid, Faiyaz HM; Saify, Zafar Saeid; Jabeen, Almas; Haider, Fouzia; Siddiqui, Rubina; Munawar, Rabya (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Benzimidazole and its derivatives found variety of biological activities, for the searching of its potent antiinflammatory analogues, we synthesized four novel 4-(2-keto-1-benzimidazollinyl) piperidine derivatives (Q1 to ...
  • Vitamin D receptor FokI polymorphism in a Pakistani population with type 2 diabetes mellitus 
    Abdul Sattar, Naila; Hussain, Fatma (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Present research was undertaken with the aim to assess the association of VDR gene FokI polymorphism with T2DM in local population. The study comprised of 100 T2DM patients (DG) and 50 normal individuals (CG) groups. Demographic ...
  • In-silico determination of pKa and logp values of some isoniazid synthetic analogues using Marvin software 
    Naeem, Sabahat; Akhtar, Shamim; Zafar, Shaista; Iqbal, Sadia (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    : Among the physicochemical properties, pKa and LogP values help us in studying drug parameters like ADME and could be predicted to some extent. With this view, here we wish to predict these two properties of our ...
  • Molecular docking and in-silico study of natural antagonists of ERalpha receptor: Potential candidates against breast cancer 
    Ahmed, Bilal; Qadir, Muhammad Imran; Hafiza Noor-ul-Ain (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Breast cancer is affecting the women in both developing and non-developing countries in a dangerous ratio. Estrogen receptor alpha (ER-α) controls a number of physiological processes. Its over expression is seen in breast ...
  • Analysis of chemical constituents in the extract and rat serum from the chloroform extract of Oxytropis falcata Bunge by HPLC-MS 
    Zhang, Dejun; Yuan, Wangtao; Zhang, Benyin; Hong, Eun-Kyung; Shi, Ping; Yang, Zhanting; Zhang, Yuhao; Wang, Honglun (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Analysis of the constituents of the chloroform extract of Oxytropis falcata Bunge (CEOF), a traditional Tibetan medicine, in rat’s serum after oral administration, has been performed by HPLC-MS. We have identified ...
  • Protective effects of rutin on kidney in type 1 diabetic mice 
    Gong, Biao; Gou, Xiangbo; Han, Ting; Qi, Yajuan; Ji, Xiaoru; Bai, Jing (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Diabetic nephropathy is one the most serious diabetic microangiopathies, which is the main cause of mortality in diabetic patients. Our research investigated the protective effects of rutin on kidney of the type 1 ...
  • Antibacterial activity of the crude extracts from medicinally important Thuja occidentalis 
    Bakht, Jehan; Zafar, Zobia; Ahmad, Jawad; Khan, Shehla (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    The present research was carried out at the Institute of Biotechnology and Genetic Engineering, The University of Agriculture Peshawar, KPK Pakistan. In this study crude methanolic extracts from Thuja occidentalis ...
  • Preparation of Uracil by bacteria isolated from Morchella 
    Fu, Shaobin; Ye, Zhang; Yang, Cailing; Meng, Qingfeng (Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi, 2020-03-16)
    Morchella is one of the most famous rare edible and medicinal fungi over the world. Highly nutritious and immature cultivation techniques led to the high price and the markets have remained tight. The pathogenic bacteria ...

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