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Now showing items 1-20 of 72

Determination of fucoidan in rat plasma by HPLC and its application in pharmacokinetics

Zhang, E; Fulong, Chu; Zhao, Tongde; Liang, Hao; Song, Shuliang; Ji, Aiguo; Chai, Yuchao (Pakistan Journal of Pharmaceutical Sciences, 2020-01-01)

This is a new expanded method of determining the characterisation of fucoidan from Laminaria japonica (kelp) in rat plasma by high-performance liquid chromatography (HPLC) with fluorescence detection. We tagged fucoidan ...
Study of the antioxidant, immunomodulatory and antibacterial properties of Origanum majorana leaf acetone extract

Mushabab Al Syaad, Khalid; Hassan Ibrahim, Essam (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-01-01)

Origanum majorana (OM) is known to have antioxidant properties. The present work was designed to evaluate, for the first time, the hepato/nephroprotective, immunomudulatory and antibacterial potentials of OM leaves acetone ...
Determination of fucoidan in rat plasma by HPLC and its application in pharmacokinetics

Zhang, E; Chu, Fulong; Zhao, Tongde; Chai, Yuchao; Liang, Hao; Song, Shuliang; Ji, Aiguo (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-01)

This is a new expanded method of determining the characterisation of fucoidan from Laminaria japonica (kelp) in rat plasma by high-performance liquid chromatography (HPLC) with fluorescence detection. We tagged fucoidan ...
Medicinal effects of saffron and chamomile on diabetes mellitus and associated hyperlipidemia and memory impairment

Ahmad, Saara; Khan, Asra; Batool, Zehra; Hassan Mehmood, Malik; Khaliq, Saima; Tabassum, Saiqa; Naeem Rajput, Shafiqa; Haider, Saida (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-01-02)

Diabetes mellitus is a multifactorial metabolic syndrome, in which FDA approved treatments have their own limitations and drawbacks. Therefore, herbal alternatives have recently garnered attention for their effectiveness ...
Synthesis, crystal studies and biological evaluation of flavone derivatives

Shoaib, Mohammad; Ali Shah, Syed Wadood; Ghias, Mehreen; Ali, Niaz; Umar, Naveed; Shah, Ismail; Shafiullah, Shafiullah; Nisar, Muhammad; Jan, Tour; Tahir, Muhammad Nawaz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-02)

Three substituted flavone derivatives have been synthesized from substituted O-hydroxy acetophenones and 4- trifluoromethyl benzaldehyde in good yield. These compounds were characterized by NMR spectroscopy and single ...
Genotoxic and cytotoxic of biosynthesized titanium dioxide nanoparticles against CaCO2 and MDA-MB-231 cell lines

Ganash, Magdah (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-01-03)

Till now there is a general lack of information concerning the genotoxic and cytotoxic effects of nanoparticles. Titanium dioxide nanoparticles (TiO2NPs) were synthesized using Trichoderma harzianum and characterized by ...
Yishenhuoxue formula regulates TGF-β/Smad signal transduction to protect rats against Diabetic kidney disease injury

Du, Na; Liu, Shunan; Cui, Chongshuang; Hao, Fang; Gao, Mingyue; Xu, Zhiping; Cao, Xia (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-03)

TGF-β signal pathway activation is vital in the pathogenesis of DKD. We aim to investigate the role of Yishenhuoxue formula on TGF-β/Smad signal transduction in DKD rats. 60 male adult Wistar rats were enrolled and randomly ...
Antimicrobial activity of different solvent extracted samples from the leaves and fruits of Capsicum annuum

Bakht, Jehan; Noor, Nimra; Iqbal, Arshad; Shafi, Mohammad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-04)

The current research describes the antimicrobial potential of methanol, n-hexane, n-butanol, ethyl acetate and aqueous extracted samples from the leaves and fruits tissues of Capsicum annuum. Different solvent extracted ...
Preparation, evaluation and pharmacokinetics of diosmin herbosome in beagle dogs

Adouani, Imene; Qureshi, Anas Sarwar; Hang, Tai-Jun (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-05)

Diosmin is one of the most widely used phlebotonic drugs, but its poor bioavailability has restricted its usage. The aim of this study was to formulate a complex Diosmin with phospholipids (75% in PC, in 1:2 molar ratios) ...
Synthesis, Bacterial biofilm inhibition and cytotoxicity of new NAlkyl/aralkyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4- nitrobenzenesulfonamides

Abbasi, Muhammad Athar; Zeb, Aurang; Rehman, Aziz-ur; Siddiqui, Sabahat Zahra; Ali Shah, Syed Adnan; Shahid, Muhammad; Fatima, Hina (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-06)

The current research was commenced by reaction of 1,4-benzodioxane-6-amine (1) with 4- nitrobenzenesulfonyl chloride (2) in the presence of aqueous base under dynamic pH control at 9 to yield N-(2,3-dihydro1,4-benzodiox ...
Influence of a herbal preparation on the pharmacokinetics of highly active antiretroviral therapy drugs in rats

Su, Qijian; Lu, Zhenzhen; Tang, Yunxia; Wei, Suosu; Zhou, Zhipin; Jiang, Feng (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-07)

Shenlin Fuzheng Capsule (SLFZC) is a herbal preparation used for HIV/AIDS in Guangxi, China. This study was designed to evaluate the influence of SLFZC on the pharmacokinetics of highly active antiretroviral therapy (HAART) ...
Rapid and reliable method for composition of concentric layers of kidney stones by fourier transform infrared spectroscopy with KSLS13

Nadeem, Beenish; Channa, Naseem Aslam; Ghanghro, Abdul Waheed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-08)

Present study is aimed to explore the rapid and reliable method of analyzing the composition of concentric layers of stones by fourier transform infrared spectroscopy with Kidney Stone Library Software (KSLS-13). Total ...
Evaluation of genetic variation, antioxidant and antibacterial activities of two Sidr varieties in Medina

Badr, Salwa Fahmy; El-Sherif, Nahla A; II, Shabana; El-Deeb, Mai; AL-Shinqiti, Fatma Yahya Mohammed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-09)

Genetic variation of two Ziziphus spina-christi L. (Sidr) varieties was determined by Random Amplified Polymorphic DNA (RAPD). The activity of antioxidant enzymes (peroxidase and catalase) was also determined for the two ...
GuaLou GuiZhi decoction represses LPS-induced BV2 activation via miR-155 induced inflammatory signals

Hu, Haixia; Zhu, Xiaoqin; Lin, Xinjun (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-01-10)

Inflammatory response that occur post-ischemia is a serious problem in the treatment of ischemic brain disease. MicroRNA-155 is a brain-specific or brain-enriched miRNA, which mediates inflammatory reactions in cerebral ...
Blend of guar gum and Eudragit shows excellent drug release retarding behavior in sustained release tablets

Ahmad, Sarah; Jamshaid, Muhammad; Mehmood, Rizwan; Bashir, Irfan; Ali, Rabia; Jameel, Sana (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-10)

The objective of the current study was to compare sustained release behavior of natural and synthetic polymers in matrix tablets of lisinopril and hydrochlorothiazide combination. Guar gum was used as a hydrophilic natural ...
Saline vs. dextrose for local anesthetic dilution in brachial plexus block: A randomized study

Mosaffa, Faramarz; Hosseini, Fahimeh; Dabir, Shideh (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-11)

Higher sodium ions in saline diluted local anesthetic may reduce the anesthetic action of the drug as injected around the nerves. However, the impact of local anesthetic dilution agents on the quality of peripheral nerve ...
Neurochemical and behavioral effects of midazolam: A dose related study

Ikram, Huma; Tasneem, Sarah; Perveen, Shahla; Haleem, Darakhshan Jabeen (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-12)

In the present study we have monitored dose dependent effects of midazolam; a benzodiazepine (CNS depressant). It is the primary drug of choice for procedural sedation, preoperative sedation, and in emergency departments. ...
Optimal extraction bioactive components of tetramethylpyrazine in Chinese herbal medicine jointly using back propagation neural network and genetic algorithm in R language

Yu, Li; Jin, Weifeng; Zhou, Jing; Li, Xiaohong; Zhang, Yuyan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-13)

A combinational approach of back propagation neural network (BPNN) and genetic algorithm (GA) was proposed in the present study to optimize the extraction technology of tetramethylpyrazine (TMP) in Ligusticum wallichii ...
Screening of water distilled Rosa damascena Mill. flowers as hematopoietic agent in an animal model

Osama, Muhammad; Ikram, Rahela; Sarfaraz, Sana; Ahmed, Shadab; Iqbal, Adnan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi, 2020-01-14)

Pancytopenia is classified as low blood cell count. Low levels of hemoglobin, red blood cells, white blood cells and platelets are indicative of pancytopenic state. This pancytopenic state can be treatment (drug) or disease ...
Clinical efficacy and drug safety of rivaroxaban in the prevention and treatment of senile thromboembolic diseases

Hongwei, Lv; Li, Ren; Daoli, Guo (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-01-15)

As a new oral anticoagulant, rivaroxaban is equivalent to warfarin in preventing and treating thromboembolism, but it can significantly reduce the occurrence of severe bleeding and fatal organ bleeding. This article analyzes ...

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