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Browsing Issue 3 by Issue Date

Now showing items 1-20 of 61

Screening of anticancer, hepatoprotective and nephroprotective effects of ethanol extract of Elephantopus scaber L.

Sulistyani, Nanik; Nurkhasanah, Nurkhasanah (Pakistan Journal of Pharmaceutical Sciences, 2020-01-05)

7.12-dimethylbenz (α)anthracene (DMBA) is a carcinogenic compound. It is metabolized in the liver by cytochrome P450 enzyme into 7.12-dimethylbenz (α) anthracene-3.4-diol-1.2-epoxide (DMBA-DE) which is more reactive and ...
Evaluation of Pyocyanin induced systemic pathogenicity of Pseudomonas aeruginosa

Rashid, Muhammad Ibrahim; Andleeb, Saadia; Ali, Amjad (Pakistan Journal of Pharmaceutical Sciences, 2020-01-05)

Pseudomonas aeruginosa (PA) is one of the most clinically significant nosocomial infectious agents. Clinical significance of this bacterium is intensified due to the phenomenon of its natural tendency for acquiring drug ...
Gelation and rheological characterization of Carbopol® in simulated gastrointestinal fluid of variable chemical properties

Hamed, Rania; Kamal, Areej; Alkilani, Ahlam Zaid (Pakistan Journal of Pharmaceutical Sciences, 2020-01-05)

Carbopol® is a hydrophilic polymer commonly used in the preparation of oral controlled-release matrix tablets. These matrices are subjected to dissolution testing to investigate the rate and mechanism of drug release. The ...
Evaluation of Pyocyanin induced systemic pathogenicity of Pseudomonas aeruginosa

Rashid, Muhammad Ibrahim; Andleeb, Saadia; Ali, Amjad (Pakistan Journal of Pharmaceutical Sciences, 2020-01-05)

Pseudomonas aeruginosa (PA) is one of the most clinically significant nosocomial infectious agents. Clinical significance of this bacterium is intensified due to the phenomenon of its natural tendency for acquiring drug ...
Effect of Toddalia asiatica extract combined with miR-483 on proliferation, apoptosis and inflammatory factors expression of osteoarthritis chondrocyte

Yan, Can; Wu, Jianjun (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-01)

This study aims to investigate the effect of Toddalia asiatica extract combined with miR-483 on osteoarthritis chondrocyte proliferation and apoptosis and expression of inflammatory factors. Osteoarthritis chondrocytes ...
Screening of anticancer, hepatoprotective and nephroprotective effects of ethanol extract of Elephantopus scaber L.

Sulistyani, Nanik; Nurkhasanah, Nurkhasanah (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-01)

7.12-dimethylbenz (α)anthracene (DMBA) is a carcinogenic compound. It is metabolized in the liver by cytochrome P450 enzyme into 7.12-dimethylbenz (α) anthracene-3.4-diol-1.2-epoxide (DMBA-DE) which is more reactive and ...
Calycosin reduces infarct size, oxidative stress and preserve heart function in isoproterenol-induced myocardial infarction model

Huang, Jie; Shen, Hongyuan; Jiang, Mi; Huang, Lihua; Yuan, Yuan; Wang, Qian (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-02)

Calycosin (CC) is a phytoestrogen, isolated from Radix astragali a well-known Chinese herb and used for treating various pathological conditions. The current study was projected to elucidate the cardio-preservative property ...
Prebiotic-like effects of chitosan on the intestinal microflora in mice

Zhang, Di; Xing, Yu; Liu, Li-kun; Li, Xin-li (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-02)

Food supplements can modulate the composition of human intestinal microflora due to the potential capacity of improving the host health. Chitosan (CS) possesses diverse biological and pharmacological effects and has been ...
Efficacy and safety of MAO-B inhibitor versus donepezil in Chinese elderly stroke patients with Alzheimer disease: A potential therapeutic option

Yang, Huaqing; Han, Weidong; Li, Hui (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-03)

This pilot study designed to evaluate the efficacy and safety of MAO-B inhibitor in comparison with Donepezil (DNP) in elderly Chinese patients with Alzheimer disease (AD). In the present clinical trial, Chinese elderly ...
Evaluation of Pyocyanin induced systemic pathogenicity of Pseudomonas aeruginosa

Ibrahim Rashid, Muhammad; Andleeb, Saadia; Ali, Amjad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-03)

Pseudomonas aeruginosa (PA) is one of the most clinically significant nosocomial infectious agents. Clinical significance of this bacterium is intensified due to the phenomenon of its natural tendency for acquiring drug ...
Comparison of the antidepressant like activity of homeopathic remedies (Argentum nitricum, Staphysagria and Ignatia amara) and their effect on the behavior of rodents

Anser, Humaira; Ikram, Rahila; Khatoon, Humera; Naeem, Sadaf; Saeed Khan, Saira; Nazim, Urooj; Imam, Shahlla; Shafiq, Yusra; Ishaque, Sumaira (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-04)

The majority of the world population suffers from mental and behavioral disorder. It is the need of the time to find an alternate of presently available medicines in order to decrease the medical expense. Homeopathic ...
Gelation and rheological characterization of Carbopol® in simulated gastrointestinal fluid of variable chemical properties

Hamed, Rania; Kamal, Areej; Zaid Alkilani, Ahlam (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-04)

Carbopol® is a hydrophilic polymer commonly used in the preparation of oral controlled-release matrix tablets. These matrices are subjected to dissolution testing to investigate the rate and mechanism of drug release. The ...
Neuroprotective and antioxidant potential of Ficus carica leaves extract in scopolamine induced memory impairment

Nadeem, Wajahat; Khaliq, Saima; Arshad, Maria; Ruby, Tabinda; Sajid, Madiha; Nawaz, Shazia; Azizuddin, Azizuddin; Haider, Saida; Batool, Zehra; Ali Khan, Rashid (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-04)

Ficus species has been reported to be used in prevention and therapy of various diseases but little information is available regarding the effects of its leaf extract on memory related disorders. This study was designed ...
Application of dopamine combined with dobutamine in children with pneumonia and heart failure

Yang Cun, Wang Jianlong (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-04)

Pediatric pneumonia and heart failure is a common critical illness in pediatrics. This article observes the clinical effects of dopamine and dobutamine in the treatment of pneumonia and heart failure. As a key neurotransmitter ...
Fabrication of niosomes containing N-acetyl glucosamine: In-vitro and ex-vivo characterizations

Sharif, Arfa; Akhtar, Naveed (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-05)

This study was designed to formulate N-acetylglucosamine (a skin lightening agent) containing advanced dosage form, niosomes. Thin film hydration technique was used to produce niosomes. The in-vitro stability studies were ...
Restraint-induced behavioral deficits are attenuated or impaired by pre- or post-injection of apomorphine: A context-based study

Ikram, Huma; Ahmed, Shoaib; Jabeen Haleem, Darakhshan (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-05)

Apomorphine, a psycho stimulant, has neuroprotective effects due to its ability to decrease oxidative stress. Stress-induced dopaminergic dysfunction might lead to posttraumatic stress disorder, depression and related ...
Efficacy of moxifloxacin combined with levofloxacin in the treatment of drug-resistant tuberculosis

Feng Qiujing, Wang Weiwei (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-05)

Drug-resistant tuberculosis is a clinically common respiratory-borne chronic infectious disease. Fluoroquinolone drugs can inhibit the replication and transcription of bacterial DNA and cause bacteria to die, and the ...
HPLC analysis and pharmacological study of Quercus dilatata Lindle. ex Royle aqueous methanolic extract in Sprague Dawley rats

Saleem, Mohammad; Khalid, Iqra; Furqan Akhtar, Muhammad; Saleem, Ammara; Rasul, Azhar; Hamid, Irfan; Shah, Muhammad Ajmal; Basheer, Ejaz; Javaid, Zeeshan (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-06)

Quercus dilatata (QD) is traditionally used to treat inflammation and pain. In the present study, aqueous methanolic extract of QD was evaluated for anti-inflammatory and anti-arthritic and anti-nociceptive potential by ...
Effects of sulfasalazine combined with moxibustion methods on patients with cold-dampness obstruction type ankylosing spondylitis

Liao, Wen-Jun; Song, Feng-Jun; Liu, Hai-Fei (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-06)

Twenty-four patients with cold, dampness, obstructive ankylosing spondylitis were treated with sulfasalazine and sulfasalazine in combination with moxibustion for 3 weeks. The results showed that the combined treatment of ...
Investigation on the urinary excretion kinetics of three atractylenolides from crude and processed Atractylodis rhizoma extracts in rats by UPLC-MS/MS

Liu, Yuhan; Qi, Xiaojie; Liu, Yuqiang; Cai, Qian; Liu, Shujing; Sun, Jianzhi; Lv, Xin (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-05-06)

Atractylodis rhizoma is a frequently-used traditional Chinese medicine in clinical practice, which have the effect of eliminating dampness and tonifying spleen. And after being processed with wheat bran, the dryness of A. ...

Now showing items 1-20 of 61

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