• Molecular detection of hupB gene of Mycobacterium tuberculosis in young patients with acute lymphoblastic leukemia (ALL) on Chemotherapy 

  Mahmood, Nasir; Nadeem Abbas, Shahzada; Nazeer, Qurat ul ain; Manzoor, Iqra; Shahid, Saman; Majeed, Asma (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-15)

  Cancer chemotherapy can lead to the mycobacterial infections. Tuberculosis has been reported a serious complication in leukemia patients who undergo chemotherapy. The study was focused to find mutations in hupB gene of M. ...
• Phytochemical, antimicrobial and time-kill kinetics potentials of Euphorbia nivulia Buch.-Ham.: A Cholistan desert medicinal plant 

  Younus, Muhammad; Mohtasheemul Hasan, Muhammad; Khalil, Sadia; Saddiq, Bushra; Ahmad, Khalil; Adnan Jamil, Qazi; Hussain Shirazi, Jafir; Hanif, Muhammad; ur-Rehman, Sajid; ur-Rehman Khan, Kashif; Imran Aziz, Muhammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-14)

  Euphorbia nivulia a locally occurring plant species possesses antiseptic, analgesic and anti-inflammatory properties and is ethnopharmacologically used in various ailments like skin, ear disorders, boils, and worm infestation. ...
• Contribution of mechanical and electrical cardiovascular factors in patients with ischemic stroke 

  Duica, Lavinia; Antonescu, Elisabeta; Totan, Maria; Pirlog, Mihail; Calina Silisteanu, Sinziana (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-13)

  Stroke represents the third - leading cause of death after heart and neoplastic isease and is one of the biggest cause of disability worldwide. Cardioembolism, through its principal mechanism - atrial fibrillation - ...
• Hepatoprotective effect of Ziziphus oxyphylla Edgew in paracetamolinduced hepatotoxic rat model 

  Farooq Awan, Asif; Shoaib Akhtar, Muhammad; Anjum, Irfan; Naveed Mushtaq, Muhammad; Fatima, Almas; ur Rehman Khan, Muti; Haider, Syed Imran (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-12)

  Ziziphus oxyphylla Edgew (Z. oxyphylla) is a small shrub to a medium sized tree. The aim of the present study was to evaluate the hepatoprotective activity of Z. oxyphylla in paracetamol-induced hepatotoxic rat model. ...
• Reference intervals for glomerular filtration function markers among pregnant women of Shandong Province, east China 

  Xu, Yanqiu; Cheng, Shiqing; Su, Yan; Liu, Bin; Luan, Fang (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-11)

  The aim of the study was to establish reference intervals (RIs) for glomerular filtration function markers among pregnant women of Shandong Province, east China. From Janunary 2017 to December 2018, we retrospectively ...
• Hypophagic and weight reducing effect of Momardica charinta fruit by Enhancing 5-HT neurotransmitter in rats brain 

  Bano, Farhat; Akhter, Naheed (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-10)

  Momardica charint seed as vegetable and folk medicine in Pakistan, India, China, Bangladesh and other Asian countries Momardica charinta also known as Kerala, bittergourd ,balsam pear. It possesses many biological active ...
• Fasudil protects retinal ganglion cells and promotes axonal regeneration 

  Zhang, Jie; Wang, Weichao; Wang, Hong; Liu, Junru; Zhang, Zhihong (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-09)

  This study was aimed to investigate whether fasudil can protect retinal ganglion cells and promote axonal regeneration by inhibiting RhoA/Rock pathway. Long Evans rats were used to establish an optic nerve injury model. ...
• An alternative approach to treat obesity with leptogenic polyherbal formulation obesecure: A randomized clinical trial study 

  Riazurrehman, Muhammad; Iqbal, Asif; Ayaz, Sultan; Khurram, Haris; Akhter, Naheed; Mahmood, Arshad; Akram, Muhammad; Rashid, Abid; Muhammad Asif, Hafiz (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-08)

  Obesity is a common disease of developing countries, including Pakistan. Obesity is a risk factor for many diseases which can be life threatening or making the person unable to perform daily routine work. In the current ...
• Treatment of maternal anemia by using oral iron drugs combined with diet therapy 

  Wenting, Jiang; Junjuan, Chen; Baoe, Jiang; He, Jiang; Xiuqin, Zhang (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-07)

  Iron deficiency anemia is a common nutritional deficiency disease in women during pregnancy, mainly due to the increased iron requirements of pregnant women and fetuses, resulting in a lack of iron elements necessary for ...
• Antibacterial activity of eco-friendly zinc nanoparticles prepared from leaf extract of Mentha piperita L. 

  Hasnain, Zuhair; Zafar, Sara; Shafqat, Usman; Perveen, Shagufta; Iqbal, Naeem; Ahmad Qaisrani, Saeed; Chattha, M Bilal; Mumtaz, Saqib (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-06)

  The study aims to prepare reliable, ecofriendly and cost efficient zinc nanoparticles (Zn NPs) by Mentha piperita L. leaf extract and zinc sulfate heptahydrate, for four pathogenic bacteria. Synthesized NPs were investigated ...
• Therapeutic effect of piracetam with nimodipine on vascular dementia after cerebral infarction 

  Zongfang, Zhang; Wenjing, Liu; Zhaomin, Chai; Lei, Zhang (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-05)

  This article investigated the clinical effects of piracetam with nimodipine in the treatment of vascular dementia (VD) after cerebral infarction. 98 patients with vascular dementia after cerebral infarction were selected ...
• Assessment and prediction of restless leg syndrome (RLS) in patients with diabetes mellitus type II through artificial intelligence (AI) 

  Iftikhar, Sadaf; Shahid, Saman; Umar Hassan, Muhammad; Ghias, Mamoona (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-04)

  This study aimed to diagnose the incidence of restless leg syndrome (RLS) in patients with diabetes mellitus (DM) type-2, thorough artificial intelligence based multilayer perceptron (MLP). 300 cases of diabetes mellitus ...
• Pharmacokinetics-based analysis of indomethacin’s anti-tumor effect and drug efficacy 

  Yan, Zhang; Jun, Zhang; Zhu, Zhao; Jingjing, Gao; Ke, Li (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-03)

  Non-steroidal anti-inflammatory drugs are commonly used anti-inflammatory analgesics in clinic. Indomethacin is a kind of NSAIDs and has anti-tumor effect. It can significantly change the growth cycle of cancer cells, ...
• Azithromycin induced contractile responses of intestinal smooth muscles: A mechanistic approach 

  Faisal, Rizwan; Nabi, Muhammad; Ali, Niaz; Wadood Ali Shah, Syed; Shakirullah, Shakirullah (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-02)

  The current work is documented to investigate the actions of azithromycin on intestinal smooth muscles as there are reports of gastrointestinal upsets with use of azithromycin. Azithromycin was tested on rabbit’s jejunal ...
• Clinical trial evaluating efficacy and safety of pemetrexed based chemotherapy regimen versus ramucirumab plus erlotinib in Chinese patients with lung cancer: A preliminary investigation 

  Mei, Qin; Ye, Lingjun; Chen, Chunyou; Lin, Hao (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-01)

  To carry out a preliminary clinical trial to compare the effectiveness and safety of pemetrexed based chemotherapy regimen in combination of cisplatin versus ramucirumab plus erlotinib in Chinese patients with metastatic ...
• Evaluation of cytokines expression in the phytoflavonoids treated epileptic rats: An in vivo study 

  Ahmed, Hammad; Ahmad Khan, Mahtab (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-22)

  Seizure are basic characteristic of epilepsy; these initiate due to irregular, excessive and synchronous electrical discharges. We aimed to determine the antiepileptic potential of phyto-flavonoids on the evaluation of the ...
• Isolation and characterization of nprB, a novel protease from Streptomyces thermovulgaris 

  Mushtaq, Amna; Mahmood Ansari, Tariq; Mustafa, Ghulam; Aslam Shad, Muhammad; Cruz-Reyes, Jorge; Jamil, Amer (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-21)

  Bacterial proteases are of great pharmaceutical importance and have a key role in various biological processes and in life cycle of several pathogens. New technology used for rational protein engineering as well improved ...
• Prevalence and risk factors associated with prenatal depression among pregnant women in Faisalabad, Pakistan 

  Habiba, Ume; Saleem Rana, Muhammad; Hanif, Asif; Amir Gilani, Syed; Asif, Muhammad; Ayaz, Sultan (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-20)

  To determine the prevalence of prenatal depression and explore its association with socio-demographic risk factors, stressful life events and women autonomy/decision-making. The recognition of these problems would play a ...
• Evaluation of efficient carbon, nitrogen sources, micro and macro nutrients for dextran production by Weissella cibaria CMGDEX3 by utilizing a modified multifactorial Placket-Burman statistical design 

  Siddiqui, Khaizran; Akhtar, Jameela; Shoeb, Erum; Badar, Uzma; Qureshi, Fouad M; Fatima, Samreen (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-19)

  In the present study previously isolated Weissella cibaria CMG DEX3 capable of producing high molecular weight, water soluble dextran (Ahmed et al., 2012) is characterized for most efficient less expensive carbon, nitrogen ...
• Antidiabetic potential of Andrographis echioides Nees. leaf extract on high fat diet-fed C57BL/6J diabetic mice 

  S, Sindhu; K, Sivakumar; V, Karthikeyan; P Jacob, Justin (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-18)

  The present study validates the antidiabetic potential of Andrographis echioides leaf extract (AeLE) on high fat diet-fed diabetic C57BL/6J mice. The male C57BL/6J mouse (age 6-8 weeks) were divided into 2 groups (lean ...

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