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Browsing Issue 5 by Issue Date

Now showing items 1-20 of 37

Clinical trial evaluating efficacy and safety of pemetrexed based chemotherapy regimen versus ramucirumab plus erlotinib in Chinese patients with lung cancer: A preliminary investigation

Mei, Qin; Ye, Lingjun; Chen, Chunyou; Lin, Hao (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-01)

To carry out a preliminary clinical trial to compare the effectiveness and safety of pemetrexed based chemotherapy regimen in combination of cisplatin versus ramucirumab plus erlotinib in Chinese patients with metastatic ...
Study of the antioxidant, immunomodulatory and antibacterial properties of Origanum majorana leaf acetone extract

Mushabab Al Syaad, Khalid; Hassan Ibrahim, Essam (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-01)

Origanum majorana (OM) is known to have antioxidant properties. The present work was designed to evaluate, for the first time, the hepato/nephroprotective, immunomudulatory and antibacterial potentials of OM leaves acetone ...
Study on vascular mechanisms underlying the hypotensive effect of Sorghum halepense (L.) Pers

Batool, Amna; Saleem, Muhammad; Alamgeer, Alamgeer; Muhammad Irfan, Hafiz; Younis, Waqas; Hadal Alotaibi, Nasser; Saad Alharb, Khalid; Nasir Abbas Bukhari, Syed; Locatelli, Marcello; Saleem, Hammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-02)

Sorghum halepense L (Poaceae), ordinarily it is known as Johnson grass and locally as baru. This study was designed to find the vascular mechanisms underlying the hypotensive activity of S. halepense. In this study, effect ...
Azithromycin induced contractile responses of intestinal smooth muscles: A mechanistic approach

Faisal, Rizwan; Nabi, Muhammad; Ali, Niaz; Wadood Ali Shah, Syed; Shakirullah, Shakirullah (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-02)

The current work is documented to investigate the actions of azithromycin on intestinal smooth muscles as there are reports of gastrointestinal upsets with use of azithromycin. Azithromycin was tested on rabbit’s jejunal ...
Design, Preparation and evaluation of various parameters of controlled release matrices of losartan potassium using polymers combination

Ahmad Khan, Kamran; Majid Khan, Gul; Ullah Shah, Kifayat; Rasul Niazi, Zahid; Khan, Haroon; Ahmad, Ashfaq; ur-Rehman, Fazal; Akhtar Shah, Pervaiz; Ullah, Aziz; Tahir, Muhammad; Umer Jan, Syed (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-03)

Controlled release formulations are administered once a day and reduce frequency of dose and ensuring patient’s compliance. In the current research controlled release matrices of losartan potassium formulated with polymeric ...
Pharmacokinetics-based analysis of indomethacin’s anti-tumor effect and drug efficacy

Yan, Zhang; Jun, Zhang; Zhu, Zhao; Jingjing, Gao; Ke, Li (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-03)

Non-steroidal anti-inflammatory drugs are commonly used anti-inflammatory analgesics in clinic. Indomethacin is a kind of NSAIDs and has anti-tumor effect. It can significantly change the growth cycle of cancer cells, ...
Derivatives of diisopropyl phenoxyphosphate with controlled reactivity for enhancement of Acetylcholine (ACh) neurotransmitter

Khadim Sheikh, Hamdullah; Arshad, Tanzila; Sher Mohammad, Zainab; Khalil Moussa, Isra; Usman, Rafia; Mohtasheemul Hasan, Muhammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-04)

Here, new phenoxide derivatives of diisopropyl flourophosphate for reaction with Lewis basic sites on acetyl cholinesterase (AChE) were designed. Such binding interaction or reaction inhibits the hydrolysis of the acetylcholine ...
Assessment and prediction of restless leg syndrome (RLS) in patients with diabetes mellitus type II through artificial intelligence (AI)

Iftikhar, Sadaf; Shahid, Saman; Umar Hassan, Muhammad; Ghias, Mamoona (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-04)

This study aimed to diagnose the incidence of restless leg syndrome (RLS) in patients with diabetes mellitus (DM) type-2, thorough artificial intelligence based multilayer perceptron (MLP). 300 cases of diabetes mellitus ...
Blood pressure lowering effects of Ranunculus scleratus Linn. in normal and fructose induced hypertensive rats and estimation of underlying mechanisms

Sharif, Amber; Alamgeer, Alamgeer; Saleem, Muhammad; Hadal Alotaibi, Nasser; Khalid, Khalid; Alharbi, Saad; Nasir Abbas Bukhari, Syed; Muhammad Irfan, Hafiz; Younis, Waqas (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-05)

Ranunculus scleratus Linn. is used in folk medicine to treat hypertension. This study was aimed at providing validation to its traditional use and to explore underlying mechanisms of action. Effects of hydro-ethanolic crude ...
Therapeutic effect of piracetam with nimodipine on vascular dementia after cerebral infarction

Zongfang, Zhang; Wenjing, Liu; Zhaomin, Chai; Lei, Zhang (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-05)

This article investigated the clinical effects of piracetam with nimodipine in the treatment of vascular dementia (VD) after cerebral infarction. 98 patients with vascular dementia after cerebral infarction were selected ...
Hematological and toxicological effects of aqueous leaf extract of Stevia rebaudiana Bertoni in normal rat modals

Ahmad, Uswa; Shabir Ahmad, Rabia; Shahbaz, Muhammad; Imran, Ali; Haseeb, Muhammad; Siddique, Farzana; Yasmin, Zarina; Ashraf, Ijaz; Masroor, Ashir; Basit, Abdul (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-06)

Stevia rebaudiana Bertoni a non-caloric, safe and natural sweetener has been shown pharmaceutically important in the management of blood disorders. This study was designed to investigate hematology and safety of stevia ...
Antibacterial activity of eco-friendly zinc nanoparticles prepared from leaf extract of Mentha piperita L.

Hasnain, Zuhair; Zafar, Sara; Shafqat, Usman; Perveen, Shagufta; Iqbal, Naeem; Ahmad Qaisrani, Saeed; Chattha, M Bilal; Mumtaz, Saqib (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-06)

The study aims to prepare reliable, ecofriendly and cost efficient zinc nanoparticles (Zn NPs) by Mentha piperita L. leaf extract and zinc sulfate heptahydrate, for four pathogenic bacteria. Synthesized NPs were investigated ...
Pharmacological investigation of activities pertaining to modulation of gastrointestinal, respiratory and cardiovascular parameters by Indigofera argentea in experimental models

Sajjad Haider, Muhammad; Imran, Imran (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-07)

Indigofera argentea is widely used for the management of gastrointestinal, respiratory and cardiac disorders. This study was done to explore scientific basis of its uses. Aqueous methanolic extract of Indigofera argentea ...
Treatment of maternal anemia by using oral iron drugs combined with diet therapy

Wenting, Jiang; Junjuan, Chen; Baoe, Jiang; He, Jiang; Xiuqin, Zhang (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-07)

Iron deficiency anemia is a common nutritional deficiency disease in women during pregnancy, mainly due to the increased iron requirements of pregnant women and fetuses, resulting in a lack of iron elements necessary for ...
Hematopoietic effects of Azadirachta indica methanolic extract in cyclophosphamide mediated myelosuppressed albino rat

Nadeem Alvi, Muhammad; Tayyab Ansari, Muhammad; Ahmed Siddiqi, Faheem; Ishaque, Ambreen; Abbas, Muhammad; Ul-Hassan, Saeed (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-08)

Myelosuppression or bone marrow suppression is one of the most common side effects caused by anti-cancer drugs. Certain nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics and viruses like B19 virus can also cause ...
An alternative approach to treat obesity with leptogenic polyherbal formulation obesecure: A randomized clinical trial study

Riazurrehman, Muhammad; Iqbal, Asif; Ayaz, Sultan; Khurram, Haris; Akhter, Naheed; Mahmood, Arshad; Akram, Muhammad; Rashid, Abid; Muhammad Asif, Hafiz (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-08)

Obesity is a common disease of developing countries, including Pakistan. Obesity is a risk factor for many diseases which can be life threatening or making the person unable to perform daily routine work. In the current ...
Eugenol and liposome-based nanocarriers loaded with eugenol protect against anxiolytic disorder via down regulation of neurokinin-1 receptors in mice

Jibran Siyal, Fahad; Memon, Zahida; Ahmed Siddiqui, Rehan; Aslam, Zara; Nisar, Uzair; Imad, Rehan; Raza Shah, Muhammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-09)

Anxiety disorder is a psychiatric disorder characterized by extreme fear or worry. It is highly prevalent worldwide which affects daily life and is also an enormous health burden. Neurokinin 1 receptor (NK1R) is a G protein ...
Fasudil protects retinal ganglion cells and promotes axonal regeneration

Zhang, Jie; Wang, Weichao; Wang, Hong; Liu, Junru; Zhang, Zhihong (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-09)

This study was aimed to investigate whether fasudil can protect retinal ganglion cells and promote axonal regeneration by inhibiting RhoA/Rock pathway. Long Evans rats were used to establish an optic nerve injury model. ...
Antimicrobial activities of silver nanoparticles of extra virgin olive oil and sunflower oil against human pathogenic microbes

Negm, Sally; Moustafa, Mahmoud; Sayed, Mahmoud; Alamri, Saad; Alghamdii, Huda; Shati, Ali; Al-Khatani, Mohmed; Alrumman, Sulaiman; Maghraby, Thanaa; Temerk, Hanan (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-10)

Silver nanoparticles were synthesized using extra virgin olive oil (Olea europaea L.) and sunflower oil (Helianthus annuus L.) and characterized by UV–vis spectroscopy, X-ray powder diffraction (XRD) and scanning electron ...
Hypophagic and weight reducing effect of Momardica charinta fruit by Enhancing 5-HT neurotransmitter in rats brain

Bano, Farhat; Akhter, Naheed (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2020-09-10)

Momardica charint seed as vegetable and folk medicine in Pakistan, India, China, Bangladesh and other Asian countries Momardica charinta also known as Kerala, bittergourd ,balsam pear. It possesses many biological active ...

Now showing items 1-20 of 37

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