Volume 32: Recent submissions

  • Hematological indices of end-stage chronic renal failure patients in Sudan: With or without iron supplements 
    Elgari, Mahmoud Mohamed; F Khabour, Omar; Abd Elmahmoud, Hanim; Elhag, Hassan; Mahmoud Muddathir, Abdel Rahim (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)
    Anemia is very common among end stage patients with chronic renal failure (CRF). In this investigation, hematological parameters were examined in patients with end stage chronic renal failure from Khartoum, Sudan. A total ...
  • Study on structural insight of the analysis of negative effects of opioids analgesics in naltrexone with TLR4 Mutations 
    Tariq, Iqra; Farhan, Ali; Ashfaq, Usman Ali; Qasim, Muhammad; Rehman, Mahmood-ur; Humayun, Fahad; Shah, Masaoud; Munir, Anum; Masoud, Muhammad Shareef (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-16)
    Chronic pain has been defined as the persistence that remained for more than three months. The extent of previous time duration with the normal time of natural healing phase becomes poor and results in reduced life quality ...
  • Anti-nociceptive potential of lyophilized Beta vulgaris L. (Beet root) powder 
    Sarfaraz, Sana; Ikram, Rahila (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-08)
    Pain is a very common symptom and pain management is most important challenge to alleviate the suffering and for improving the quality of life of those living with chronic pain. Beet root is a vegetable consumed as salad ...
  • Hepato-protective effect of Allium sativum against immobilization stress in rats 
    Syed Kashif Zaidi; Shakeel Ahmed Ansari; Shams Tabrez; Ghulam Md. Ashraf; Shazi Shakil; Mohammad Alam Jafri; Muhammad Imran Naseer; Wesam H Abdulaal; Naheed Banu; Muhammed Al-Qahtani (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-07)
    The purpose of the current study was to examine immobilization stress-induced antioxidant defense changes and estimation of the antioxidant potential of pre and post stress treatment of aqueous garlic extract in rat’s ...
  • Chewable cough tablets with improved palatability: A comparative phase II clinical trial 
    Khan, Mehwish; Rehman, Hina; Naveed, Safila; Zaidi, Syed Faisal; Ayaz, Sultan; Owais, Aymen; Usmanghani, Khan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-15)
    Cough is the common disease condition which affects patients of every age. Numerous OTC medications available in community pharmacies however no antiviral treatment and even antibiotics has been shown to be effective ...
  • Development of thiomer based buccal films for the enhancement of bioavailability: An in-vivo analysis 
    Zaman, Muhammad; Hanif, Muhammad; Wahab Amjad, Muhammad; Mahmood, Asif; Shah, Shahid; Ghafoor Raja, Maria Abdul; Rasool, Shahid; Sarfraz, Rai Muhammad (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)
    Present work was conducted to improve the bioavailability of Tizanidine HCl (TZN) by formulating mucoadhesive buccal films (MBFs) using novel thiolated arabinoxylan (TAX) as film former. MBF‟s were prepared by solvent ...
  • Development and validation of RP-HPLC method for determination of Lornoxicam in rabbit’s plasma 
    Shah, Syed Nisar Hussain; Sohail, Kashif; Javaid, Zeeshan; Zaman, Muhammad; Basheer, Ejaz (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-14)
    A simple, rapid and accurate reverse phase high performance liquid chromatographic (RP- HPLC) method was developed for the quantification of lornoxicam in oral disintegrating tablets (ODTs) and in rabbit’s plasma. C18 ...
  • In vitro antimicrobial activity and phytochemical analysis of different solvent extracted samples from medicinally important Litsea glutinosa 
    Bakht, Jehan; Farooq, Muhammad; Iqbal, Arshad (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-06)
    The present research work investigate the antimicrobial activities of crude methanolic extracted samples from the leaves of Litsea glutinosa against different microorganisms through disc diffusion assay applied in two ...
  • Cardioprotective effect of 6-shogaol against hyperglycemia-induced toxicity in H9c2 cardiomyocytes via suppressing of NF-κB pathway 
    Malki, Waleed Hassan Al; Abdel-Raheem, Ihab Talat (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-13)
    Diabetic cardiomyopathy (DC) is a serious complication of diabetes. Apoptosis, inflammatory and ROS production are among the factors that are involved in the progression of diabetic cardiomyopathy. 6-shogaol is reported ...
  • Antidiabetic and antidyslipidemic potential of Echinops echinatus in rat models of type I and type II diabetes 
    Chaudhry, Shafqat Rasul; Akram, Adnan; Aslam, Naveed; Wajid, Muhammad; Iqbal, Zafar; Nazir, Imran; Jabeen, Qaiser; Muhammad, Sajjad (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-05)
    Echinops echinatus is traditionally an important plant that finds its extensive use as a diuretic, antiinflammatory, anti-pyretic, nerve tonic, abortifacient, aphrodisiac, antiasthmatic, and antidiabetic agent. The current ...
  • Prevalence and co-infection of Malaria and Typhoid in the local population of Faisalabad, Pakistan 
    Jalani, Hasan Abdaal; Shah, Syed Muhammad Ali; Anjum, Fozia; Khan, Samreen Gul; Akhter, Naheed; Khan, Muslim; Akram, Muhammad; Tahir, Imtiaz Mahmood; Munir, Naveed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-12)
    Malaria and typhoid fever are among the major infectious diseases which impose significant health and socioeconomic burden on affected populations. Further, co-infection and resembling symptomatology in both infections, ...
  • Detection of paracetamol as substrate of the gut microbiome 
    Mukhtar, Imran; Anwar, Haseeb; Hussain, Ghulam; Rasul, Azhar; Naqvi, Syed Ali Raza; Naeem Faisal, Muhammad; Mustafa, Imtiaz; Malik, Saima; Shaukat, Arslan; Mirza, Osman Asghar; Sohail, Muhammad Umar (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2019-03-20)
    Gut microbiome, a new organ; represent targets to alter pharmacokinetics of orally administered drugs. Recently, in vitro trials endorsed the idea that orally administered drugs interact and some of their quantity may be ...
  • Acute and sub acute toxicity study and randomized clinical trial of polyherbal coded drug candicure in the management of acute vulvovaginal candidiasis 
    Sultana, Sabira; Qureshi, Tasneem; Asif, Hafiz Muhammad; Akram, Muhammad; Ayaz, Sultan; Shah, Syed Muhammad Ali (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-11)
    Vulvo-Vaginal Candidiasis is common gynecological disorder. Clinical trials are designed to evaluate the effect of medical intervention with allopathic and herbal medicine to treat vulvo-vaginal candidiasis. The toxicity ...
  • Metabolomics and marker-based stability studies of methanol extract of seeds of Syzygium cumini L 
    Islam, Muhammad; Shehzad, Naureen; Salman, Muhammad; Zahi, Fakhra; Qamar, Shaista; Danish, Muhammad Z; Saeed, Hamid; Hashmi, Furqan K; Khan, Humaira M; Khan, Muhammad T; Bukhar, Nadeem I; Hussain, Khalid (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-03-04)
    Though, herbal medicines are prone to deterioration upon storage due to their complex nature, but less attention has been paid to investigating stability of such products to assign shelf-life. Therefore, the present study ...
  • Glucagon-like peptide-1 attenuates liver injury in the rat diabetes model 
    Yang, Zhenxing; Guo, Caiyun; Ma, Jun; Lu, Yang; Xuan, Liping; Huang, Yongmin; Yang, Xiaoyu; Zhao, Minxia; Luo, Yaner (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-10)
    The aim of present study is to examine the effect of glucagon-like peptide-1(GLP-1) on diabetes-induced liver injury and explore detailed mechanisms of GLP-1 hepatoprotective effect. 150 male Sprague-Dawley rats were ...
  • Glucagon-like peptide-1 attenuates liver injury in the rat diabetes model 
    Yang, Zhenxing; Guo, Caiyun; Ma, Jun; Lu, Yang; Xuan, Liping; Huang, Yongmin; Yang, Xiaoyu; Zhao, Minxia; Luo, Yaner (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-10)
    The aim of present study is to examine the effect of glucagon-like peptide-1(GLP-1) on diabetes-induced liver injury and explore detailed mechanisms of GLP-1 hepatoprotective effect. 150 male Sprague-Dawley rats were ...
  • Presence of gallic acid and rutin improve the hepatoprotective strength of Withania coagulans 
    Qureshi, Shamim Akhtar; Jahan, Musarrat; Lateef, Tooba; Ahmed, Dildar; Rais, Sumera; Azmi, Muhammad Bilal (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-09)
    Carbon tetrachloride (CCl4) is one of the chemicals used in industry reported to accelerate the risk of liver diseases in workers especially in developing countries, if it is not handled carefully. Therefore, the present ...
  • Investigation of antiaging and skin rejuvenation potential of phytoconstituents from Pyrus communis loaded topical emulgel 
    Khiljee, Tanzila; Akhtar, Naveed (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-08)
    Pyrus communis fruit is traditionally used for improving the skin color and texture. The current study was designed to investigate Pyrus communis fruit phytoconstituents and their in-vivo rejuvenation effects on human ...
  • Antioxidant and antimicrobial activities of various extracts from Engleromyces sinensis fruiting body 
    Wang, Fei; Zhou, Xiao; Shen, Xiao-Ye; Hou, Cheng-Lin (Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, 2019-04-03)
    Engleromyces sinensis, as rare macro-ascomycetes and traditional ethnomedicine in the southeast part of China, have been applied in anti-infection, anti-inflammatory and anti-tumor for a long time. In this study, ...
  • MiR-145 inhibited lipopolysaccharide-induced apoptosis of gastric mucosal via up-regulating JNK-mediated cytoprotective autophagy 
    Meng, Fanyong; Chen, Jihua; Long, Qinglin; Liu, Dong (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-01-07)
    It has been reported that specific microRNA could inhibit apoptosis of gastric mucosa. Our study was designed to investigate the effect and mechanisms of miR-145 in gastric mucosa. Gastric mucosal cells (GES-1) were treated ...

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