• Renin Angiotensin Aldosterone System (RAAS): Its biology and drug targets for treating diabetic nephropathy 

  Maryam Zain; Awan, Fazli Rabbi (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)

  Diabetes mellitus is a multifactorial disorder of hyperglycemia caused by a combination of biochemical, molecular and genetic factors, which leads to the dysfunction of various organs including kidneys. Diabetic nephropathy ...
• Prostate cancer: Leading and misleading routes to TRAIL of death 

  Farooq, Ammad Ahmad; Qureshi, Muhammad Zahid; Abdur Rehman; Nogueira, Daniele Rubert; Awan, Imrana Iftikhar; Adeela Shahid (Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi., 2014-09-20)

  Prostate cancer is a multifaceted disease that arises because of misrepresentation of linear and integrated signaling cascades that regulate gene network in normal and cancer cells. Programmed cell death is modulated by ...
• REPORT A comparative study of loratidine physiochemical properties from different brands 

  Safila Naveed; Huma Dilshad; Sheeba Urooj (Karachi: Faculty of Pharmacy, University of Karachi, 2018-12-05)

  Loratidine is a piperidine derivative resemble to azatadine long acting non sedating commonly used for the treatment of allergic condition like watery or itchy eyes, runny nose, chronic urticaria or throat itching. In the ...
• REPORT Attenuation of apomorphine induced behavioral sensitization in rats pre-treated with tryptophan 

  Muhammad Farhan; Darakshan Jabeen Haleem (Karachi: Faculty of Pharmacy, University of Karachi, 2018-12-04)

  Psychostimulants substances, some of which are abused by humans, are generally believed to produce sensitization effects when they are repeatedly administered to animals. Apomorphine, a non-narcotic derivative of morphine, ...
• REPORT Effect of macrophage alone or primed with cytokines on Balamuthia mandrillaris interactions with human brain microvascular endothelial cells in vitro 

  Abdul Matin; Salik Nawaz; Jung, Suk-Yul (Karachi: Faculty of Pharmacy, University of Karachi, 2018-12-03)

  Balamuthia mandrillaris is well known to cause fatal Balamuthia amoebic encephalitis (BAE). Amoebic transmission into the central nervous system (CNS), haematogenous spread is thought to be the prime step, followed by ...
• REPORT Safety and toxicological evaluation of herbal formulation on rodents 

  Farzana Sadaf; Sumbul Shamim; Rubeena Saleem; Navaid-ul-Zafar (Karachi: Faculty of Pharmacy, University of Karachi, 2018-12-02)

  Herbal medicines are still most popular, abundant and affordable remedies for curing various ailments. Garlina is one of the herbal formulations of Hamdard Laboratories (waqf) Pakistan used to treat cardiovascular diseases ...
• REPORT Wound healing activity of Hymenocallis littoralis - Moving beyond ornamental plant 

  Sundarasekar, Jeevandran; Sahgal, Geethaa; Murugaiyah, Vikneswaran; Lay, Lam Kit; Thong, Ong Ming; Subramaniam, Sreeramanan (Karachi: Faculty of Pharmacy, University of Karachi, 2018-12-01)

  Spider lily (Hymenocallis littoralis) belongs to Amaryllidaceae family is a well-known plant species for its medicinal properties. The inhibitory effects of H. littoralis methanol sonication extracts were evaluated for ...
• In vitro antibacterial susceptibility of different brands of oral levofloxacin 250 mg tablet against Staphylococcus aureus and Escherichia coli 

  Raheela Bano; Adeel Arsalan (Karachi: Faculty of Pharmacy, University of Karachi, 2018-11-30)
• In vitro antibacterial activity and phyto-chemistry of samples from the roots of Viola pilosa 

  Maria Khan Panni; Jehan Bakht (Karachi: Faculty of Pharmacy, University of Karachi, 2018-11-29)

  Anti-microbial activity and phytochemical analysis of samples from the roots of Viola pilosa was studied against six strains of bacteria. Data indicated that the tested bacterial strain differed in its sensitivity to the ...
• Stability indicating HPLC method for simultaneous quantification of sildenafil citrate and dapoxetine hydrochloride in Pharmaceutical products 

  Liew, Kai Bin; Peh, Kok Khiang (Karachi: Faculty of Pharmacy, University of Karachi, 2018-11-28)

  A stability-indicating HPLC-UV method for the simultaneous determination of sildenafil citrate and dapoxetine hydrochloride in solution and tablet was developed. The mobile phase was comprised of acetonitrile and 0.2M ...
• Comparative analgesic evaluation of Himalrandia tetrasperma and Wendlandia exserta of family Rubiaceae after induction of pain in mice 

  Muhammad Ajaib; Saiqa Ishtiaq; Muhammad Faheem Siddiqu (Karachi: Faculty of Pharmacy, University of Karachi, 2018-11-27)

  Himalrandia tetrasperma and Wendlandia exserta medicinal plants belong to family Rubiaceae commonly known as coffee family were investigated by quantitative analysis of major bioactive compounds and analgesic effect. The ...
• Evaluation of fast disintegrating tablets of paracetamol prepared from a blend of croscarmellose sodium and Pleurotus tuber-regium powder 

  Eraga, Sylvester Okhuelegbe; Arhewoh, Matthew Ikhuoria; Akpan, Faith Emmanuel; Iwuagwu, Magnus Amara (Karachi: Faculty of Pharmacy, University of Karachi, 2018-11-26)

  The study investigated the combination effects of the mixture of croscarmellose sodium and Pleurotus tuberregium powder on the granules and tableting parameters of paracetamol tablets. Five batches (A-E) of paracetamol ...
• Cellulase-assisted extraction and anti-ultraviolet activity of polysaccharides from the root of Flammulina velutipes on Caenorhabditis elegans 

  Li, Zhenjing; Zhang, Yanan; Lin, Lin; Cui, Haiyan; Wang, Tiantian; Chen, Mianhua; Wang, Changlu (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-11-24)

  We investigated the cellulase-assisted extraction and anti-ultraviolet activity of water-soluble polysaccharides from the root of Flammulina velutipes on Caenorhabditis elegans. A Box–Behnken design experiment with three ...
• Synthesis of 2-Furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives as suitable antibacterial agents with mild cytotoxicity 

  Muhammad Athar Abbasi; Muhammad Mubashar Nazeer; Aziz-ur-Rehman; Sabahat Zahra Siddiqui; Ghulam Hussain; Syed Adnan Ali Shah; Irshad Ahmad; Muhammad Shahid; Muhammad Salman Sarwar (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-11-23)

  The aim of the present research work was synthesis of some 2-furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives and to ascertain their antibacterial potential. The cytotoxicity of these molecules was also checked to ...
• The effect of ivermectin on secondary spermatocytes and serum total proteins 

  Sweify, Karima Mohammad; Darwish, Iman Abd El Moneim; Hafez, Dalia Demerdash Abd El Monem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-11-22)

  Ivermectin, a broad-spectrum anti-parasitic agent first used in veterinary medicine, is active against numerous species of helminths and arthropods. In this study, we aimed to demonstrate the effects of administration of ...
• Extraction and isolation of important bioactive compounds from the fruit of Physalis ixocarpa 

  Wajid Khan; Wajid Khan; Muraleedharan G Nair; Muhammad Nazir Uddin; Mohammad Shaf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-11-21)

  The current study investigates pharmaceutically important bioactive compounds in the fruits of Physalis ixocarpa. Two different extractions methods were used to study its effect on percent extract yield, recovery of ...
• Protective effects of Butea frondosa leaves against stress induced immune impairment in sprague dawley rats 

  Aleza Rizvi; Abbas Ali Mahdi; Shadma Wahab; Mishra, Anuradha (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-11-20)

  Stress is thought to impair immune function through emotional or behavioral manifestations thus the present study was done to assessed the effect of ethanolic extract of Butea frondosa (BF) leaves on behaviour, immunomodulatory ...
• Prevalence of Hepatitis C genotypes in District Swabi, Khyber Pakhtunkhwa 

  Shabeer Ahmed; Abdul Sajid; Muhammad Sadiqu; Mian Muhammad Salman; Natasha Kashif; Sohail Ahmad (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-11-19)

  The present study was conducted to determine the prevalence and genotype of Hepatitis C in District Swabi. Blood samples were collected from 100 seropositive patients from various hospitals of District Swabi, out of which, ...
• A computational structural analysis of functional attributes of hypodermin A and B proteins: A way forward for vaccine development 

  Irum Arif; Abdul Rauf Siddiqi; Haroon Ahmed; Muhammad Inam Afzal; Muhammad Umer; Arooma Maryam; Rana Rehan Khalid; Saira Asif; Muhammad Sohail Afzal; Shabnum Shaheen; Sadaf Abdul Rauf; Ozyalin, Ozge; Simsek, Sami (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-11-18)

  Hypodermosis is a parasitic disease of cattle. The pathogenicity of the disease is attributed to Hypodermin proteins (Hypodermin A, Hypodermin B and Hypodermin C). Studies suggest that Hypodermin proteins may be defined ...
• Preliminary investigations of banana (Musa paradisiaca) starch mucilage as binder in metformin tablet formulation 

  Eraga, Sylvester Okhuelegbe; Arhewoh, Matthew Ikhuoria; Agboola, Janet Olamiposi; Iwuagwu, Magnus Amara (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2018-11-17)

  The binding properties of banana (Musa paradisiaca) starchwas investigated using maize starch BP and polyvinylpyrrolidone (PVP) as standards in the formulation of metformin tablets. Starch from unripe banana fruits was ...

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