• REVIEW Novel synthetic curcuminoids: Not merely an anticancer agent 

  Zhang, Hailei; Jiang, Xiaonan; Song, Weihua; Yang, Zhangqun (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-08-05)

  Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to exhibit biological activity towards different kinds of diseases. But the low oral bioavailability results in a limited ...
• REPORT Biochemical and molecular characterization of catalase enzyme in the saprobic fungus: Sordaria fimicola 

  Muhammad Ishfaq; Nasir Mahmood; Muhammad Akbar; Idrees Ahmad Nasir; Muhammad Saleem (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-08-04)

  Fungi have been used in modern scientific research due to their high potential for different enzymes production based on genomic features. The great proportion of soil mycoflora represented by saprobic fungi plays an ...
• SHORT COMMUNICATION Anticancer activity of Ziziphus mauritiana roots against human breast cancer cell line 

  Marium Batoo; Samina Afzal; Khurram Afzal; Bilal Ahmed; Khizar Abbas; Syed Aun Muhammad; Muhammad Imran Qadir (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-08-03)

  This study was designed to evaluate the anticancer activity of Ziziphus mauritiana roots. The dichloromethane and methanol extracts were prepared and anticancer activity was investigated the by using MTT assay. Human ...
• SHORT COMMUNICATION Pattern of anti-tuberculosis drugs susceptibility in new and previously treated tuberculosis patients and environmental risk factors investigation 

  Salma Hameed; Nasir Mahmood; Chaudhry, Muhammad Nawaz; Sajid Rashid Ahmad; Mohammad Aqeel ur Rahman; Salma Hameed; Chaudhry, Muhammad Nawaz; Nasir Mahmood (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-08-02)

  Resistance pattern both in newly and previously treated-TB patients and risk factors associated in spread of tuberculosis are investigated in the current study. A total 244 Mycobacterium tuberculosis isolates were used ...
• Phenolic contents, elemental analysis, antioxidant and lipoxygenase inhibitory activities of Zanthoxylum armatum DC fruit, leaves and bark extracts 

  Fiaz Alam; Qazi Najam us Saqib; Mohammad Ashraf (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-08-01)

  Zanthoxylum armatum (DC) is a traditional spice and important herb used in Asia as a part of food and household medicine for the treatment of various conditions. The present study was designed to investigate in vitro for ...
• In vitro hepatoprotective activity of Sargassum wightii against CCl4 induced hepatic damage 

  Gunasekaran, Suja; Thirumalairaj, Vinoth Kumar; Ashokan, Lakshmana Senthil Shanmuga; Pitchai, Suganya; Yesudas, Rincy; Chacko, Amrutha (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-25)

  In vitro hepatoprotective activity of Sargassum wightii methanolic extract was checked using established cell culture (Hep G2) and primary rat hepatocytes. In Hep G2 cells, the extract concentrations varying from 31.25-500 ...
• Comparative effect of Beta blocker-Atenolol and Murraya koenigii (L.) spreng (Curry leaves) on cardiac enzyme (CK-MB) level in male albino rats 

  Anum Butt; Nazish Waris; Kulsoom Baqa; Urooj Nazim; Afshan Naz; Abbasi, Sumera Rais; Sumreen Begum (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-24)

  Murraya koenigii (L.) spreng (curry leaves) have traditionally been used for its various medicinal properties. The current study was conducted to assess the comparative effect of Murraya koenigii (L.) spreng (curry leaves) ...
• Extraction optimization of polyphenols from fruits of Pyracantha fortuneana (Maxim.) Li by ultrasonic assistant method and their antibacterial activity 

  Sun, Hongyan; Wang, Xiaoyun; Zhou, Zhaowei; Wang, Rui (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-23)

  The present study was designed to utilise ultrasound assistance technology to optimize the extraction conditions of polyphenols, and identify their antibacterial activity from fruits of Pyracantha fortuneana (Maxim.) Li, ...
• Cocos nucifera (Coconut) water of different maturity stages affects hematological and coagulation parameters in rabbits: A positive lead 

  Sadia Saleem Rao; Rahila Ikram (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-22)

  Cocos nucifera (coconut) water is a traditionally used beverage and sportsdrink around the world. The recommendations on the use of plants for different conditions often lack proper scientific research. This study is first ...
• Oral administration of Lactobacillus acidophilus alleviates exacerbations in Pseudomonas aeruginosa and Staphylococcus aureus pulmonary infections 

  Affhan Shoaib; Xin, Lu; Xin, Yi (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-21)

  Staphylococcus aureus and Pseudomonas aeruginosa are largely the cause of morbidity and mortality in both hospital and community settings. These pathogens remain the important cause of pulmonary infections in patients ...
• GC-MS analysis of bioactive compounds present in medicinally important Periploca hydaspidis 

  Rafi Ullah; Jehan Bakht; Muhammad Raza Shah (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-20)

  The present study investigates the pharmaceutically bioactive compounds in Methanol, n-hexane and ethyl acetate extracted samples from the root of Periploca hydaspidis through Gas Chromatography and Mass Spectroscopy ...
• Determination of related substances in ketoprofen injection by RP-HPLC method 

  LUO, Lei; Tan, Mingguo; LUO, Yonghuang (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-19)

  The paper aims to establish a RP-HPLC method for the simultaneous determination of six related substances in ketoprofen injection. The separation was performed on a VP-ODS C18 column (4.6mm×250mm, 5μm) with the mobile ...
• The prognosis value of C-reactive protein and endothelin-1 in chronic obstructive pulmonary disease patients with pulmonary artery pressure 

  Yan, Fang; Pidayi, Muyeshaer; Xia, Yu; Hu, Xin; Yang, Zengrong (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-31)

  Chronic Obstructive Pulmonary Disease (COPD), which is caused by various proinflammatory cytokines, will present some kinds of complication with progression such as Pulmonary Artery Hypertension (PAH). CRP (C-Reactive ...
• Antioxidative, protein kinase inhibition and antibacterial potential of seven mango varieties cultivated in Pakistan 

  Mamoona Suleman; Joham Sarfraz Ali; Ihsan ul Haq; Sobia Nisa; Muhammad Zia (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-30)

  Peel, pulp and kernel extracts of seven mango fruit (varieties) were analyzedsubjected for antibacterial and antioxidative potential. Langra peel showed good activity against B. subtilis, S. aureus and E. aerogenes. Good ...
• Identification and control of specific aflatoxin-producing fungi in stored maize seeds in awka using azadirachta indica (neem) and garcinia kola seeds 

  Nnedinma, Achugbu Adaeze; Ejiofor, Amadi Jude; Blessing, Ukonze Chikodili; Nkechukwu, Ikegbunam Moses (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-29)

  Four fungal isolates were identified in this study of which three were Aspergillus species with Aspergillus flavus having the highest frequency followed by A. parasiticus. The result of high frequency of Aspergillus flavus ...
• Formulation, characterization and in vitro evaluation of antifungal activity of Nystatin microemulsion for topical application 

  Iram Maqsood; Muhammad Irfan Masood; Hafiz Awais Nawaz; Iram Shahzadi; Naheed Arslan (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-28)

  The current research aims at development and assessment of o/w nystatin microemulsion. The pseudoternary phase diagrams were developed to determine microemulsion existence regions by water titration method. Nystatin was ...
• Antihyperalgesia potency of Zingiber officinale var. Rubrum in inflammatory and neuropathy-induced chronic pain condition in mice 

  Fajrin, Fifteen Aprila; Purwandhono, Azham; Christianty, Fransisca Maria; Sulistyaningrum, Gati Dwi; Afifah; Imandasari, Nidia; Barki, Tsabit (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-27)

  Chronic inflammation and neuropathic pain are classified into chronic pain. Until now there are so many drugs that have been used for chronic pain but the effectiveness still lower. One of the plants that are commonly ...
• Phytochemical and antimicrobial study of Alstonia scholaris leaf extracts against multidrug resistant bacterial and fungal strains 

  Ihsan Ullah Khan Altaf; Muhammad Medrar Hussain; Abdur Rahim (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-26)

  In the present study, Alstonia scholaris leaves were explored for phytochemical constituents, antibacterial and antifungal potentials. Phytochemical screening of the extracts established the presence of glycosides, ...
• Hypoglycemic potential of some seaweeds from Karachi coast of Pakistan 

  Perveen Akhtar; Khan Hira; Ambreen; Viqar Sultana; Jehan Ara; Syed EhteshamulHaque (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-18)

  Hypoglycemic activity of ethanol extracts and polysaccharides of seaweeds were studied in Sprague Dawley rats. Based on primary screening of ethanol extracts of 10 seaweeds, three Spatoglossum variabile, Stokeyia indica ...
• Effect of gamma radiation on combination therapy of certain antiepileptic drugs in rats 

  Ekram Nemr Abd Al Haleem; Shaimaa Salah Eldeen Hussein; Hanan Abdel-Hameed Fahmy; Ragia Ali Mahmoud Taha (Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi, 2019-07-17)

  The current study was designed to estimate the effect of γ-radiation on male rats pretreated with Levetiracetam (LEV) and/ or Oxcarbazepine (OXC). Poly-treatment of rats with LEV, OXC and γ-radiation showed a significant ...

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