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Preformulation study and initial determination of biological Properties of isopropylidene shikimic acid

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dc.contributor.author Qu, Changhai
dc.contributor.author Lin, Longfei
dc.contributor.author Yin, Xingbin
dc.contributor.author Zhang, Xiaoyan
dc.contributor.author Yang, Pei
dc.contributor.author Zhang, Hui
dc.contributor.author Kong, Hui
dc.contributor.author Wu, Huangyan
dc.contributor.author Ni, Jian
dc.date.accessioned 2022-10-07T10:25:43Z
dc.date.available 2022-10-07T10:25:43Z
dc.date.issued 2018-11
dc.identifier.citation Qu, C., Lin, L., Yin, X., Zhang, X., Yang, P., Zhang, H., ... & Ni, J. (2018). Preformulation study and initial determination of biological Properties of isopropylidene shikimic acid. Pakistan Journal of Pharmaceutical Sciences, 31(6), 2329-2332. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12789
dc.description.abstract Isopropylidene shikimic acid (ISA), a new drug derviatived from Shikimic Acid, had been proved to be effective in the cerebral protection after cerebral ischemia and reperfusion. But there was little research on the physical pharmacy and biopharmaceutical properties about the drug. In order to provide some useful data for the pharmaceutical development of ISA, the solubility, stability and Oil/Water partition coefficient (LogP) were determined by the classic preformulation study method, and the transmembrane performance of ISA was studied by Franz -diffusion cell method in vitro. The results showed that ISA was water-soluble with a solubility 32.52mg/ml, which could be improved to 44.32 mg/ml by 1% (w/v) sodium dodecylsulfate; the LogP was -0.63; ISA was less stable in water but it was stable when pH greater than 6.0 and unstable when pH less than 6.0; the accumulated permeation rates at 1h were about 50% and more than 80% at 6h. Data obtained by the study indicated that the medium selection and pH control were important for liquid preparation of ISA, and avoiding dissolution and absorption in stomach was critical for the oral solid dosage forms. Mucosal drug delivery systems would be considered, according to the certain hydrophilic-lipophilic characters and good transmembrane capability. en_US
dc.language.iso en_US en_US
dc.publisher Pakistan Journal of Pharmaceutical Sciences University of Karachi en_US
dc.subject Preformulation study en_US
dc.subject isopropylidene shikimic acid en_US
dc.subject stability en_US
dc.subject partition coefficient en_US
dc.subject transmembrane en_US
dc.title Preformulation study and initial determination of biological Properties of isopropylidene shikimic acid en_US
dc.type Article en_US


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