Abstract:
The study was designed to investigate the neuro-protection of lauric acid (LA) on haloperidol (HPD) induced
Parkinson’s disease (PkD) rat model. Rats were divided into group A (normal), group B (diseased, by HPD 1mg/kg i.p.
for 14 days), group C (standard treatment, levodopa 30 mg/kg), group D (vehicle coconut oil 1ml/kg), group E (LA
0.66mg/kg) and group F (LA 1.32mg/kg) for 35 days after induction of PkD. The study displayed a state of oxidative
stress in the striatum of rat model of PkD as shown from the increased MDA, NO levels and the decreased superoxide
dismutase levels. HPD caused an increase in tumor necrosis factor-α level, NF-кB, IL-8 mRNA expression and suppress
IL-4 expression. Neuro-protection with LA attenuated the oxidative stress and changes in pro-inflammatory cytokines
induced due to PkD induction. The LA treatment also showed improvement in the histo-pathology of the rats’ brain. LA
also improved behavioral performances, food intake, weight gain as compared to animal of diseased group and prevented
decline in motor activities (assessed Rotarod, and Beam walking test). LA showed significant neuro-protection against
oxidative stress, inflammatory cytokines and behavioral changes in HPD induced rat model of PkD.
