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Relationship of oxidative stress with elevated level of DNA damage and homocysteine in cardiovascular disease patients

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dc.contributor.author Qasim, Muhammad
dc.contributor.author Bukhari, Shazia Anwer
dc.contributor.author Ghani, Madiha Javeed
dc.contributor.author Masoud, Muhammad Shareef
dc.contributor.author Huma, Tayyabah
dc.contributor.author Arshad, Muhammad
dc.contributor.author Haque, Asma
dc.contributor.author Ibrahim, Zubair
dc.contributor.author Javed, Sadia
dc.contributor.author Rajoka, Muhammad Ibrahim
dc.date.accessioned 2022-10-07T10:39:05Z
dc.date.available 2022-10-07T10:39:05Z
dc.date.issued 2016-11-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12794
dc.description.abstract Amounts of DNA damage and homocysteine (Hcy) in heart patients blood may have strong function in the causation of cardiovascular disease (CVD). The main objective of this work was to know experimentally the role of total oxidants (produced by Reactive Oxygen species (ROS), clinical biochemical indices, their oxidized products and total antioxidant status (TAS) among such patients to find the association of homocysteine, total oxidation status (TOS) and oxidative DNA damage with other clinical parameters in sixty positive CVD patients compared with those of 60 normal subjects. As compared to healthy individuals, CVD patients had significantly higher concentrations of homocysteine (p<0.0001), total oxidants stress (TOS) (p<0.0001), serum total lipids (p<0.04), malondialdehyde (MDA) (p<0.001), high density lipoprotein-cholesterol (HDL-C) (p<0.0001), and low density lipoprotein cholesterol (LDL-C) (p<0.01), than those of healthy individuals. Plasma Hcy content, TOS and amount of DNA were positively and significantly associated with cholesterol, triglycerides, systolic blood pressure, urea, and albumin (p values<0.01). TOS, Hcy and oxidative DNA damage were negatively correlated with HDL-c, TAS and proteins. It is suggested that these parameters have pivotal role in diagnostic process of determining severity in CAD patients. Oxidized products of macromolecules in blood of CVD patients impart major functions in causing CVD disease. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Antioxidants en_US
dc.subject heart disease en_US
dc.subject CVD en_US
dc.subject homocysteine en_US
dc.subject TOS en_US
dc.subject DNA damage en_US
dc.subject malondialdehyde en_US
dc.subject 8-Hydroxy2’deoxyguanosine en_US
dc.title Relationship of oxidative stress with elevated level of DNA damage and homocysteine in cardiovascular disease patients en_US
dc.type Article en_US


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