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Effect of Shexiang baoxin pills on clopidogrel resistance in patients with acute coronary syndrome

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dc.contributor.author Zhang, Li
dc.contributor.author Liu, Na
dc.contributor.author Zhang, Jinying
dc.contributor.author Zhang, Hui
dc.date.accessioned 2022-10-07T10:41:41Z
dc.date.available 2022-10-07T10:41:41Z
dc.date.issued 2016-11-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12796
dc.description.abstract To explore the effect of Shexiang baoxin pills on clopidogrel resistance in patients with acute coronary syndrome (ACS). 131 cases with ACS combining with clopidogrel resistance admitted to our hospital during March 2013 to November 2015 were recruited in this study and were divided into observation group (66 cases) and control group (65 cases) according to the random number table method. And the patients in observation group were given clopidogrel with Shexiang baoxin pills therapy while the control group clopidogrel therapy to observe the platelet aggregation rate, heart rate variability (HRV), and serum level of matrix metalloproteinase-2 (MMP-2). After treatment, the platelet aggregation rate in observation group was significantly less than the group before treatment and that of control group (P<0.05); And before treatment, the serum level of MMP-2 and HRV of the two groups were not statistically significant (P>0.05). But after treatment, the serum level of MMP-2 and HRV of the observation group were significantly lower and better respectively than the observation group before treatment and control group (P<0.05). Shexiang baoxin pill plays an active role in reducing clopidogrel resistance in patients with ACS, lowering platelet aggregation rate and serum level of MMP-2, improving HRV in the body en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Shexiang baoxin pill en_US
dc.subject acute coronary syndrome en_US
dc.subject clopidogrel resistance en_US
dc.subject influence en_US
dc.title Effect of Shexiang baoxin pills on clopidogrel resistance in patients with acute coronary syndrome en_US
dc.type Article en_US


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