Abstract:
Diabetes is a disease characterized by elevated uncontrolled glucose level. Hyperglycemia results in diabetic
complication due to a reaction between sugar and amino acid of proteins to form advanced glycation endproducts
(AGEs) in different tissues. Medicinal plants are considered as a great source of bioactive compounds that affect many
ailments. In this regard; AGEs formation could be inhibited by many bioactive compounds isolated from medicinal
plants. Viscum schimperi Engl. is a plant belongs to Loranthaceae and known for its antidiabetic activity. In this study;
total methanol extract of V. schimperi (VT) was prepared, suspended in water and subjected to fractionation with
chloroform followed by n-butanol to give (VC) and (VB) fractions respectively. The aqueous mother liquor was
evaporated to form (VA) fraction. The inhibitory effect of all prepared fraction on the formation of advanced glycation
endproducts (AGEs) was studied. The results revealed that V. schimperi extract and its different fractions inhibited
protein glycation and oxidation of BSA induced by ribose together with decrease of protein aggregation. In conclusion;
V. schimperi will be useful in management of diabetic complications based on its inhibition of advanced glycation
endproduct formation.
