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Effect of Viscum schimperi on advanced glycation endproducts formation

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dc.contributor.author Abdallah, Hossam Mohamed
dc.contributor.author ALGhamdi, Doha Omar
dc.contributor.author Al-Salem, Maab Siddiq
dc.contributor.author Alattas, Maryam
dc.contributor.author El-Bassossy, Hany Mohamed
dc.contributor.author Alahda, Abdulrahman Mohammed
dc.contributor.author Shehata, Ibrahim Ateya
dc.contributor.author Abdel-Sattar, Essam
dc.date.accessioned 2022-10-07T10:42:41Z
dc.date.available 2022-10-07T10:42:41Z
dc.date.issued 2016-11-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12798
dc.description.abstract Diabetes is a disease characterized by elevated uncontrolled glucose level. Hyperglycemia results in diabetic complication due to a reaction between sugar and amino acid of proteins to form advanced glycation endproducts (AGEs) in different tissues. Medicinal plants are considered as a great source of bioactive compounds that affect many ailments. In this regard; AGEs formation could be inhibited by many bioactive compounds isolated from medicinal plants. Viscum schimperi Engl. is a plant belongs to Loranthaceae and known for its antidiabetic activity. In this study; total methanol extract of V. schimperi (VT) was prepared, suspended in water and subjected to fractionation with chloroform followed by n-butanol to give (VC) and (VB) fractions respectively. The aqueous mother liquor was evaporated to form (VA) fraction. The inhibitory effect of all prepared fraction on the formation of advanced glycation endproducts (AGEs) was studied. The results revealed that V. schimperi extract and its different fractions inhibited protein glycation and oxidation of BSA induced by ribose together with decrease of protein aggregation. In conclusion; V. schimperi will be useful in management of diabetic complications based on its inhibition of advanced glycation endproduct formation. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Viscum schimperi en_US
dc.subject advanced glycation endproducts en_US
dc.subject diabetic complications en_US
dc.subject anti-diabetic en_US
dc.subject Saudi plants en_US
dc.title Effect of Viscum schimperi on advanced glycation endproducts formation en_US
dc.type Article en_US


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