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Development and optimization of flurbiprofen loaded microsponges: An in vitro evaluation

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dc.contributor.author Qureshi, Sundus
dc.contributor.author Zaman, Muhammad
dc.contributor.author Mahmood, Asif
dc.contributor.author Shah, Shahid
dc.contributor.author Amjad, Muhammad Wahab
dc.contributor.author Shaheryar, Zaib Ali
dc.contributor.author Sarfraz, Rai Muhammad
dc.contributor.author Khan, Sajid Mahmood
dc.contributor.author Ghafoor Raja, Maria Abdul
dc.date.accessioned 2022-10-07T10:43:52Z
dc.date.available 2022-10-07T10:43:52Z
dc.date.issued 2019-07-11
dc.identifier.citation Qureshi, S., Zaman, M., Mahmood, A., Shah, S., Amjad, M. W., Shaheryar, Z. A., ... & Raja, M. A. G. (2019). Development and optimization of flurbiprofen loaded microsponges: An in vitro evaluation. Pak. J. Pharm. Sci, 32(4), 1773-1779. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12799
dc.description.abstract Current study was designed with the aim to employ quasi emulsification, and double emulsification techniques for the development of Flurbiprofen (FLB) loaded micro sponges, followed by their physicochemical evaluation. FTIR interpretations exhibited compatibility of ingredients, while crystallographic analysis revealed crystalline nature of pure drug, which was masked upon incorporation into microsponges. Optical microscope and SEM have exposed spherical and spongy surfaces of prepared micro sponges. Micromeritics suggested that the flow properties are excellent and microsponges have remarkable drug entrapment efficiency (98.55±0.08%). In-vitro dissolution studies demonstrated good control over release of FLB until 8th h from the prepared microsponges. However, a difference in cumulated amount of released drug was noticed i.e. EC based formulation has released about 99.3±0.10%, while XG facilitated EC based formulations offered 92.7±2.1% release of the drug. Zeta potential indicated access of negative charge while zeta sizer has described the range of the particle size between 2.6 to 3.5µm. Conclusively the results have advocated the suitability of selected ingredients for incorporation of FLB into microsponges for its sustained delivery. en_US
dc.language.iso en_US en_US
dc.publisher Karachi, Pakistan Journal of Pharmaceutical Sciences, University of Karachi en_US
dc.subject : Drug delivery en_US
dc.subject sustainable materials en_US
dc.subject scanning electron microscopy en_US
dc.subject micro sponges en_US
dc.subject double emulsification technique en_US
dc.title Development and optimization of flurbiprofen loaded microsponges: An in vitro evaluation en_US
dc.type Article en_US


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