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Therapeutic Effect of Atorvastatin on kidney functions and urinary excretion of Glimepiride in healthy adult human male subjects

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dc.contributor.author Sana, Tayyaba
dc.contributor.author Aslam, Bilal
dc.contributor.author Aslam, Nosheen
dc.contributor.author Ashraf, Muhammad Mudassar
dc.contributor.author Ashraf, Asma
dc.contributor.author Malik, Tahir Aqeel
dc.contributor.author Niazi, Sammia Gul
dc.contributor.author Tahir, Imtiaz Mahmood
dc.contributor.author Riaz-ur-Rehman, Muhammad
dc.contributor.author Ahmed, Hamad
dc.date.accessioned 2022-10-07T10:46:30Z
dc.date.available 2022-10-07T10:46:30Z
dc.date.issued 2016-11-16
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12803
dc.description.abstract Glimepiride and Atorvastatin in combination are commonly employed for treating the hyperglycemia and dyslipidemia, respectively, in patients of type 2 diabetes. The present study was designed to find out the influence of Atorvastatin on urinary excretion and renal clearance of Glimepiride in healthy adult male volunteers. In each experimental subject, Glimepiride 2mg was given orally after an overnight fasting. Samples of blood and urine were taken at different specific time intervals. After a washout period of ten days, Glimepiride 2mg was co-administered with Atorvastatin 20mg orally. Post-medication, blood and urine samples were collected following the same sampling schedule as for Glimepiride alone. The samples were analyzed for Glimepiride and creatinine concentration by HPLCUV and Spectrophotometer, respectively. Mean (±SE) values for blood pH 7.445±0.05 and 7.382±0.05, urine pH 4.972±0.08 and 5.08±0.10, diuresis 0.0207±0.00 and 0.0237±0.00ml/min/kg, endogenous creatinine in plasma 9.048±0.33 and 8.613±0.024µg/ml, endogenous creatinine in urine 512.34±18.20 and 556.72±4.60µg/ml, Glimepiride plasma concentration 0.16069±0.00 and 0.3227±0.01µg/ml, Glimepiride urine concentration 1.5994±0.03 and 0.8665±0.04µg/ml, renal clearance of creatinine 1.224±0.09 and 1.550±0.09ml/min/kg, renal clearance of Glimepiride 0.2064±0.01 and 0.0641±0.00ml/min/kg and clearance ratio 0.1791±0.01 and 0.0414±0.00 were observed for Glimepiride alone and its concurrent administration with Atorvastatin, respectively. Atorvastatin decreased the urinary excretion and renal clearance of Glimepiride due to which chances of hypoglycemia provokes and renal handling of Glimepiride involves back diffusion besides glomerular filtration and no influence of Atorvastatin was seen on these mechanisms. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi en_US
dc.subject Drug interaction en_US
dc.subject Renal clearance en_US
dc.subject Healthy volunteers en_US
dc.subject Glimepiride en_US
dc.subject Atorvastatin en_US
dc.title Therapeutic Effect of Atorvastatin on kidney functions and urinary excretion of Glimepiride in healthy adult human male subjects en_US
dc.type Article en_US


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