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Neurada procumbens promotes functions regain in a mouse model of mechanically induced sciatic nerve injury

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dc.contributor.author Rasul, Azhar
dc.contributor.author Al-Shawi, Ali AA
dc.contributor.author Ahmad Malik, Shoaib
dc.contributor.author Anwar, Haseeb
dc.contributor.author Rasool, Bilal
dc.contributor.author Razzaq, Aroona
dc.contributor.author Aziz, Nimra
dc.contributor.author Shahid Kamran, Syed Kashif
dc.contributor.author Sarfraz, Iqra
dc.contributor.author Shabbir, Asghar
dc.contributor.author Selamoglu, Zeliha
dc.contributor.author Hussain, Ghulam
dc.date.accessioned 2022-10-07T10:56:36Z
dc.date.available 2022-10-07T10:56:36Z
dc.date.issued 2019-07-13
dc.identifier.citation Rasul, A., Al-Shawi, A. A., Malik, S. A., Anwar, H., Rasool, B., Razzaq, A., ... & Hussain, G. (2019). Neurada procumbens promotes functions regain in a mouse model of mechanically induced sciatic nerve injury. Pak J Pharm Sci, 32(4), 1761-1766. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12818
dc.description.abstract Peripheral nerve injury is a complex condition which results in restricted physical activity. Despite the tremendous efforts to figure out effective remedies, the complete functional retrieval is still a goal to be achieved. So, the need of hour is the exploration of potential natural compounds to recover this functional loss. Here, we have investigated the role of a local plant “Neurada procumbens” in ameliorating the functional recovery after an induced nerve compression injury in a mouse model. A dose of N. procumbens (50mg/kg of body weight) was administered orally from the day of injury to onwards. The motor functional recovery was assessed by evaluating muscle grip strength and sciatic functional index; while the sensory functions were gauged by the hotplate test. The serological parameters were carried out to analyze the effect of N. procumbens on oxidative stress level. The recovery of sensory and motor functions was significantly improved and perceived earlier in the treatment group. Moreover, the elevated antioxidant level was statistically significant in the treatment group. These results indicate that the supplementation of N. procumbens accelerates functional recovery after sciatic nerve crush injury. en_US
dc.language.iso en_US en_US
dc.publisher Karachi, Pakistan Journal of Pharmaceutical Sciences, University of Karachi en_US
dc.subject : Peripheral nerve injury en_US
dc.subject sensory functions recovery en_US
dc.subject motor functions recovery en_US
dc.subject Neurada procumbens en_US
dc.title Neurada procumbens promotes functions regain in a mouse model of mechanically induced sciatic nerve injury en_US
dc.type Article en_US


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