Abstract:
: This study was designed to analyze the pharmacological effects of Typha domingenesis crude 70% aqueousethanol extract of Typha domingensis (Td. Cr) in gastrointestinal, respiratory and vascular diseases. Rabbits (2.0-3.0 kg)
and BALB/c mice (20-40 g) of local breed have been used as experimental animals using the established methodologies
from literature with slight modification. The findings suggested that Typha domingensis caused complete relaxation of
spontaneous and K+ (80mM)-induced contractions in isolated rabbit jejunum. Rightward parallel shift of calcium
concentration response curves was observed. Typha domingensis exhibited relaxant effect on Carbachol (Cch)-induced
contractions in isolated rabbit tracheal preparations. Furthermore, Typha domingensis caused relaxation of phenylephrine
(1μM)- induced contractions in isolated rabbit aorta preparations. These effects were similar to verapamil, a standard
calcium channel blocker. These findings could be the basis for explaining the spasmolytic, bronchodilator and
vasodilator activities of the extract, through a possible calcium channel blocking activity.
