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Conbercept and Retinal Photocoagulation in the treatment of Diabetic Macular Edema

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dc.contributor.author Meng, Weizhe
dc.contributor.author Li, Ronghua
dc.contributor.author Xie, Xiufen
dc.date.accessioned 2019-11-14T10:33:06Z
dc.date.available 2019-11-14T10:33:06Z
dc.date.issued 2019-01-01
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/1290
dc.description.abstract Objective: To explore the clinical efficacy of intravitreal injection of conbercept in combination with retinal laser photocoagulation in the treatment of diabetic macular edema. Methods: Ninety patients with diabetic macular edema were selected and grouped into an observation group and a control group using random number table, 45 patients (45 eyes) each group. The control group was given retinal laser photocoagulation, while the observation group was given intravitreal injection of Conbercept on the basis of panretinal photocoagulation. The Best Corrected Visual Acuity (BCVA), thickness of retinal nerve fibre layer (RNFL) and macular thickness were measured through relevant examinations before and after treatment. The intraocular pressures of patients in the two groups were evaluated, and moreover the complications were recorded. Results: The RNFL thickness and macular thickness of the two groups had no statistically significant differences before treatment (P>0.05) and decreased significantly after treatment; the decrease amplitude of the observation group was significantly larger than that of the control group (P<0.05). The BCVA of both groups significantly increased in the 1st, 2nd and 4th week after treatment (P<0.05); the increase amplitude of BCVA of the observation group was more significant than that of the control group at different time points after treatment (P<0.05). The intraocular pressure of the observation group was not significantly different with that of the control group in the 1st, 2nd and 4th week after treatment (P>0.05). There were no severe eye complications and systemic adverse reactions in both groups in the process of follow up. Conclusion: Intravitreal injection of conbercept in combination with retinal laser photocoagulation performs better in improving the BCVA and central macular thickness of patients with diabetic macular edema compared to retinal laser photocoagulation and has high safety en_US
dc.language.iso en_US en_US
dc.publisher Pak J Med Sci en_US
dc.subject Medical and Health Sciences en_US
dc.subject Conbercep en_US
dc.subject Retinal photocoagulation en_US
dc.subject Diabetic macular edema en_US
dc.title Conbercept and Retinal Photocoagulation in the treatment of Diabetic Macular Edema en_US
dc.type Article en_US


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