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Synthesis, spectral characterization and antimicrobial studies of novel series of allylidene based multifaceted chalcones analogues

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dc.contributor.author Irshad, Misbah
dc.contributor.author Ali, Qamar
dc.contributor.author Athar Abbasi, Muhammad
dc.contributor.author Iram, Fozia
dc.contributor.author Saadia, Mubshara
dc.contributor.author Hamza Ishfaq, Muhammad
dc.date.accessioned 2022-10-11T10:48:42Z
dc.date.available 2022-10-11T10:48:42Z
dc.date.issued 2020-05-09
dc.identifier.citation Irshad, M., Ali, Q., Abbasi, M. A., Iram, F., Saadia, M., & Ishfaq, M. H. (2020). Synthesis, spectral characterization and antimicrobial studies of novel series of allylidene based multifaceted chalcones analogues. Pakistan Journal of Pharmaceutical Sciences, 33(3), 987-996. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12950
dc.description.abstract Following the Claisen Schmidt condensation a series of chalcone, their allylidene derivatives and metallic complexes were produced and subsequently screened for antibacterial assay. The precursors were simple acetophenone and different substituted aryl benzaldehydes; which were made to react in basic ethanolic conditions. The structure of synthesized targets was established by IR, 1H-NMR and EIMS data. The antibacterial statistics showed that most of the bacterial strains particularly S. typhi and E. coli were potently inhibited by majority of the compounds like 3c, 5c, 7a & 7c. This structure activity relationship studies showed that these molecules possessed p-methoxy substituents in their framework and found active in rupturing the cell wall. These molecules might serve as potential drug candidates for future drug discovery and design. The presented manuscript highlights the pharmacological diversity of chalcones holding allylidene moiety and Zn+2 complexes. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Chalcones en_US
dc.subject allylidene en_US
dc.subject 1H-NMR en_US
dc.subject EIMS en_US
dc.subject metallation en_US
dc.title Synthesis, spectral characterization and antimicrobial studies of novel series of allylidene based multifaceted chalcones analogues en_US
dc.type Article en_US


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