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Chlorogenic acid inhibits forming of diabetes mellitus in rats induced by high-fat high-sucrose and streptozotocin

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dc.contributor.author Wang, Yan
dc.contributor.author Peng, Shuguang
dc.contributor.author Mei, Zihan
dc.contributor.author Jin, Chenzhong
dc.contributor.author Kang, Jinhe
dc.contributor.author Xiang, Minghui
dc.contributor.author Wang, Zheng
dc.contributor.author Hu, Yihong
dc.date.accessioned 2022-10-12T03:38:50Z
dc.date.available 2022-10-12T03:38:50Z
dc.date.issued 2020-05-14
dc.identifier.citation Wang, Y., Peng, S., Mei, Z., Jin, C., Kang, J., Xiang, M., ... & Hu, Y. (2020). Chlorogenic acid inhibits forming of diabetes mellitus in rats induced by high-fat high-sucrose and streptozotocin. Pakistan Journal of Pharmaceutical Sciences, 33(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12960
dc.description.abstract To evaluate the inhibitory effect of chlorogenic acid on the forming of type 2 diabetes mellitus (T2DM), using Sprague Dawley (SD) rats, a recognized T2DM model induced by high-fat high-sucrose diet (HFSD) and streptozotocin (STZ). Thirty female SD rats were assigned equally to three groups randomly: normal control with standard commercial (NC), chlorogenic acid treatment with HFSD and chlorogenic acid (90mg/kg, CA), and diabetes model with HFSD (DM). Upon treatment with chlorogenic acid, suppression of the onset of diabetes, reduced serum glucose and insulin concentrations, improved glucose tolerance and increased body weight and visceral fat weight were observed. Serum triglyceride, total cholesterol, low density lipoprotein levels, and kidney and pancreas morphology were significantly ameliorated. Chlorogenic acid also inhibited the mRNA levels of hepatic G-6-Pase and up-regulated the mRNA levels of skeletal muscle GLUT4. Our results indicated that before the onset of diabetes, chlorogenic acid had an inhibitory effect against the forming of T2DM induced by HFSD and STZ through regulating the glucose and lipid metabolism. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Chlorogenic acid en_US
dc.subject Type 2 diabetes mellitus en_US
dc.subject high-fat high-sucrose diet en_US
dc.subject hepatic glucose-6-phosphatase en_US
dc.subject skeletal muscle glucose transporter 4 en_US
dc.title Chlorogenic acid inhibits forming of diabetes mellitus in rats induced by high-fat high-sucrose and streptozotocin en_US
dc.type Article en_US


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