Abstract:
The aim of study was to synthesize 1-indanyl isoniazid and sixteen other hydrazide Schiff base derivatives
from 1-indanone. All synthesized derivatives were screened for the inhibitory activity against Mycobacterium
tuberculosis on three Mycobacterial strains ATCC H37Rv, known INH-sensitive (INH-S) and INH-resistant strains (INH-R) by proportion method. The derivatives were characterized using different spectroscopic techniques such as UVVisible, FTIR, 1H NMR, and HREIMS. In addition, to gain more insight into morphology of the structures, Scanning
electron microscopy (SEM) was also performed. The results revealed that 1-indanyl isoniazid derivative (UN-1)
exhibited more potent and high anti-mycobacterial activity against both INH-sensitive and INH-resistant strains of Mycobacterium tuberculosis when compared to standard anti-tubercular drug isoniazid which might be a novel isoniazid derivative as a new anti-tubercular agent.
