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In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones
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| dc.contributor.author | Arshia, Arshia | |
| dc.contributor.author | Abbasi, Sanaullah | |
| dc.contributor.author | Rasheed, Saima | |
| dc.contributor.author | AJ Khan, Jalaluddin | |
| dc.contributor.author | Muhammad Saad, Syed | |
| dc.contributor.author | Mohammed Khan, Khalid | |
| dc.contributor.author | Choudhary, M Iqbal | |
| dc.date.accessioned | 2022-10-12T03:43:30Z | |
| dc.date.available | 2022-10-12T03:43:30Z | |
| dc.date.issued | 2020-05-19 | |
| dc.identifier.citation | Abbasi, S., Rasheed, S., Khan, J. A., Saad, S. M., Khan, K. M., & Choudhary, M. I. (2020). In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones. Pakistan Journal of Pharmaceutical Sciences, 33(3), 1147-1154. | en_US |
| dc.identifier.issn | 1011-601X | |
| dc.identifier.uri | http://142.54.178.187:9060/xmlui/handle/123456789/12972 | |
| dc.description.abstract | Fifteen benzophenone thiosemicarbazones were synthesized and their in vitro antiglycation activity was evaluated. The most active compound 2 (IC50 = 118.15±2.41μM) showed two folds potent activity than the standard, rutin (IC50 = 294.5±1.5μM). Compounds 1 and 3-7 showed good to moderate antiglycation activity in the range of 204.14 - 488.54μM. These compounds were also evaluated for antioxidant activity. Their structure-activity relationships have been developed. The results reveal the potential of these compounds as leads for further studies towards the development of antidiabetic drugs. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. | en_US |
| dc.subject | Benzophenone | en_US |
| dc.subject | thiosemicarbazone | en_US |
| dc.subject | advanced glycation end products (AGEs) | en_US |
| dc.subject | antioxidant | en_US |
| dc.subject | diabetes | en_US |
| dc.subject | structure-activity relationship (SAR) | en_US |
| dc.title | In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones | en_US |
| dc.type | Article | en_US |
