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Effect of paroxetine on intestinal motility in the presence of ondansetron

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dc.contributor.author Afzal, Ayesha
dc.contributor.author Khan, Ammara
dc.contributor.author Khan, Asma
dc.contributor.author Farooqi, Rashida
dc.contributor.author Tayyaba Khan, Bushra
dc.contributor.author Ara, Iffat
dc.date.accessioned 2022-10-12T03:44:48Z
dc.date.available 2022-10-12T03:44:48Z
dc.date.issued 2020-05-21
dc.identifier.citation Afzal¹, A., Khan, A., Khan, A., Farooqi, R., Khan, B. T., & Ara, I. (2020). Effect of paroxetine on intestinal motility in the presence of ondansetron. Pak. J. Pharm. Sci, 33(3), 1169-1172. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12975
dc.description.abstract Chemotherapy, radiotherapy, surgery and depression are the conditions that run in parallel fashions. All these conditions cause the release of an increased amount of serotonin in the body. Serotonin acts on these 5HT3 receptors and causes nausea and vomiting. Ondansetron acts by blocking serotonin from acting on the receptors and thus is useful in decreasing episodes of nausea and vomiting but when used concomitantly with SSRIs (selective serotonin reuptake inhibitors) as cancer patient also suffered from depression. This combination tends to decrease the efficacy of ondansetron. The present study was carried out to observe the modulatory role of ondansetron on ileal smooth muscle motility in vitro. Experiments were performed in four groups (n=6) and ileal smooth muscle activity was recorded on the power lab (USA). The effects of increasing concentrations of serotonin, ondansetron and paroxetine alone were observed. In the fourth group effects of paroxetine in the presence of fixed concentration (1ml) of ondansetron (10ˉ6M) was observed. The maximum response obtained by serotonin served as a control for our study (100%). Paroxetine response on intestinal motility was completely blocked in the presence of ondansetron. Our findings hence, reinforce the hypothesis that paroxetine decreases the antiemetic activity of serotonin antagonist ondansetron, by super sensitization of serotonergic receptors resulting in an increased incidence of nausea and vomiting in cancer patient despite adequate antiemetic prophylaxis. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Serotonin en_US
dc.subject ondansetron en_US
dc.subject paroxetine en_US
dc.subject ntestinal motility en_US
dc.subject SSRI’s en_US
dc.subject 5 HT3 en_US
dc.title Effect of paroxetine on intestinal motility in the presence of ondansetron en_US
dc.type Article en_US


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