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Design, Preparation and evaluation of various parameters of controlled release matrices of losartan potassium using polymers combination

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dc.contributor.author Ahmad Khan, Kamran
dc.contributor.author Majid Khan, Gul
dc.contributor.author Ullah Shah, Kifayat
dc.contributor.author Rasul Niazi, Zahid
dc.contributor.author Khan, Haroon
dc.contributor.author Ahmad, Ashfaq
dc.contributor.author ur-Rehman, Fazal
dc.contributor.author Akhtar Shah, Pervaiz
dc.contributor.author Ullah, Aziz
dc.contributor.author Tahir, Muhammad
dc.contributor.author Umer Jan, Syed
dc.date.accessioned 2022-10-12T06:05:15Z
dc.date.available 2022-10-12T06:05:15Z
dc.date.issued 2020-09-03
dc.identifier.citation Khan, K. A., Khan, G. M., Shah, K. U., Niazi, Z. R., Khan, H., Ahmad, A., ... & Jan, S. U. (2020). Design, Preparation and evaluation of various parameters of controlled release matrices of losartan potassium using polymers combination. Pakistan Journal of Pharmaceutical Sciences, 33. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/12990
dc.description.abstract Controlled release formulations are administered once a day and reduce frequency of dose and ensuring patient’s compliance. In the current research controlled release matrices of losartan potassium formulated with polymeric combinations of ethocel grade 7 with carbopol 934P NF using different concentrations of polymers. In some polymeric tablets, Co-excipients like CMC, Starch, HPMC was added by replacing of 10% of filler in formulations at 10:5. Tablets were prepared by direct compression method and evaluated for physicochemical characteristics. USP Method-1 (rotating basket method) was used to carry out dissolution study in phosphate buffer pH 6.8. Drug release kinetics determined and comparison of dissolution patterns was done with reference tablets. The polymeric combinations well retarded drug release and drug was released by anamolous non-fickian diffusion mechanism. Dissolution profiles of tested tablets and reference tablets were found not similar. Drug release rate was increased by co-excipients. It was concluded from this research work that this polymeric combination can be used efficiently in designing of controlled release martices. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Controlled release formulation en_US
dc.subject dissolution en_US
dc.subject combination en_US
dc.subject Losartan Potassium en_US
dc.title Design, Preparation and evaluation of various parameters of controlled release matrices of losartan potassium using polymers combination en_US
dc.type Article en_US


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