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The neuroprotective effect of apigenin against OGD/R injury in rat hippocampal neurons

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dc.contributor.author Ding, Yue-Min
dc.contributor.author Lin, Jiang-Tao
dc.contributor.author Fang, Lu-Mei
dc.contributor.author Lou, Zhang-Qi
dc.contributor.author Liang, Ge-nan
dc.contributor.author Zhang, Xiao-yue
dc.contributor.author Li, Ai-qing
dc.contributor.author Zhang, Xiong
dc.date.accessioned 2022-10-13T10:05:00Z
dc.date.available 2022-10-13T10:05:00Z
dc.date.issued 2020-07-11
dc.identifier.citation Ding, Y. M., Lin, J. T., Fang, L. M., Lou, Z. Q., Liang, G. N., Zhang, X. Y., ... & Zhang, X. (2020). The neuroprotective effect of apigenin against OGD/R injury in rat hippocampal neurons. Pakistan Journal of Pharmaceutical Sciences, 33(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13084
dc.description.abstract To investigate the effects of apigenin on the injury caused by oxygen and glucose deprivation in neurons and the underlying mechanisms, primary cultured rat hippocampal neurons were incubated with apigenin for 90 min before a 2-h oxygen and glucose deprivation followed by a 24-h reperfusion (OGD/R). Subsequently, cell viability, lactate dehydrogenase (LDH) leakage rate, apoptotic rate of neurons and activity of the sodium pump were assessed. In addition, activity of the sodium pump was also examined in the hippocampus of SD rats injected intraperitoneally with apigenin 90 min before a 10-min global cerebral ischemia/24-h reperfusion. The results showed that cell viability and activity of the sodium pump markedly decreased but LDH leakage rate and apoptotic rate significantly increased in OGD/R-treated neurons. However, pretreatment with apigenin (20-50μmol/L) reversed the changes dose-dependently. Compared to sham controls, activity of the sodium pump was significantly suppressed in global ischemia/reperfusion rats; application of apigenin (200mg/kg) restored the activity of the sodium pump. Furthermore, the neuroprotective effect of apigenin was blocked partly by the sodium pump inhibitor ouabain. Our findings provide the evidence that apigenin has a neuroprotective effect against OGD/R injury and the protective effect may be associated with its ability to improve sodium pump activity. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Apigenin en_US
dc.subject neuron en_US
dc.subject ischemia en_US
dc.subject sodium pump en_US
dc.title The neuroprotective effect of apigenin against OGD/R injury in rat hippocampal neurons en_US
dc.type Article en_US


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