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Pharmacokinetics and vasodilating effect study of beraprost sodium in healthy volunteers

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dc.contributor.author Li, Pingli
dc.contributor.author Zhang, Rui
dc.contributor.author Yuan, Guiyan
dc.contributor.author Chen, Keguang
dc.contributor.author Liu, Huanjun
dc.contributor.author Wang, Yanyan
dc.contributor.author Sami Shaikh, Abdul
dc.contributor.author Wang, Benjie
dc.contributor.author Li, Rong
dc.contributor.author Guo, Ruichen
dc.date.accessioned 2022-10-13T10:25:51Z
dc.date.available 2022-10-13T10:25:51Z
dc.date.issued 2020-07-27
dc.identifier.citation Li, P., Zhang, R., Yuan, G., Chen, K., Liu, H., Wang, Y., ... & Guo, R. (2020). Pharmacokinetics and vasodilating effect study of beraprost sodium in healthy volunteers. Pakistan Journal of Pharmaceutical Sciences, 33(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13120
dc.description.abstract Currently beraprost sodium (BPS) is widely proposed to ameliorate the symptoms caused by chronic arterial occlusive disease. The objective of this study is to investigate the BPS pharmacokinetic characteristics, its vasodilating effect and the relationship between plasma concentration vs response effect. 12 healthy Chinese volunteers (6 male, 6 female) were chosen to participate in a single center, random, and open design study. After overnight fasting, BPS (dose = 40μg) was administrated orally to each volunteer. The blood samples were collected at different time points (from 0 to 5 h after administration) and BPS concentration was analyzed by LC-MS/MS method. The vasodilating effect was evaluated by detecting the skin microcirculation blood flow of volunteers’ fingers with laser Doppler fluxmetry. The Cmax of BPS was (601.14 ± 214.81) pg/mL, the Tmax was (0.58 ± 0.48) h, and AUC0-t was (1020.41±214.63) pg/mL·h. BPS exhibited significant vasodilating effect since the skin microcirculation blood flow increased definitely at 0.25, 0.5, and 0.75 h (all p<0.05) after drug administration, and a positive correlation was presented between the pharmacokinetics and the vasodilating effect, which would be beneficial for guiding BPS dosage in clinical. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Beraprost sodium en_US
dc.subject pharmacokinetics en_US
dc.subject vasodilating effect en_US
dc.subject skin microcirculation blood flow en_US
dc.title Pharmacokinetics and vasodilating effect study of beraprost sodium in healthy volunteers en_US
dc.type Article en_US


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