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Antinephrolithiatic activity of Ananas comosus extract against experimentally induced renal calculi in rats

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dc.contributor.author A Sayed, Amany
dc.contributor.author R Fahmy, Sohair
dc.contributor.author M Soliman, Amel
dc.contributor.author M Mohamed, Dina
dc.date.accessioned 2022-10-13T10:28:45Z
dc.date.available 2022-10-13T10:28:45Z
dc.date.issued 2020-07-30
dc.identifier.citation Sayed, A. A., Fahmy, S. R., Soliman, A. M., & Mohamed, D. M. (2020). Antinephrolithiatic activity of Ananas comosus extract against experimentally induced renal calculi in rats. Pakistan Journal of Pharmaceutical Sciences, 33(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13126
dc.description.abstract The present study evaluates the prophylactic role of Ananas comosus ethanolic extract (ACEE) against sodium oxalate (NaOx) - induced nephrolithiasis. Forty two rats were allocated into the following set of groups (6 rats/set group). Normal rats divided to two groups, one of them received distilled water (Control group) and the other received ACEE (1000 mg/kg body weight, p.o) for 7 consecutive days. Urolithiatic rat groups which divided into five subgroups injected with sodium oxalate (70 mg NaOx /kg body weight, i.p) for 7 days; and concurrently received oral administration of distilled water (Urolithiatic group, Vehicle), ACEE and Cystone. Interestingly, ACEE showed a beneficial effect in preventing stone formation. Significant reductions were obtained in the urinary and serum calcium and phosphate excretion along with an increase in magnesium excretion in urolithiatic rats treated with ACEE. Urolithiatic rats treated with ACEE and cystone significantly increased the urinary volume. Administration of ACEE caused significant amelioration in renal function which suggests antilithiatic activity of ACEE. Moreover, urolithiatic rats treated with ACEE significantly attenuated oxidative damage induced by NaOx. In conclusion, ACEE has antilithiatic efficacy may be due to its diuretic activity, antioxidant activity, beside its bioactive constituents which affecting calcium oxalate crystallization. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Ananas comosus ethanolic extract en_US
dc.subject nephrolithiasis en_US
dc.subject sodium oxalate en_US
dc.subject urinary stone en_US
dc.subject oxidative stress en_US
dc.title Antinephrolithiatic activity of Ananas comosus extract against experimentally induced renal calculi in rats en_US
dc.type Article en_US


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