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Phytochemical analysis and reappraisal of diuretic activity of Delphinium brunonianum Royle and its mode of action in experimental rats

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dc.contributor.author Asif, Hira
dc.contributor.author Alamgeer, Alamgeer
dc.contributor.author Ishfaq Ahmad, Muhammad
dc.contributor.author Hadal Alotaib, Nasser
dc.contributor.author Saad Alharbi, Khalid
dc.contributor.author Syed Nasir Abbas Bukhari
dc.contributor.author Saleem, Hammad
dc.contributor.author Locatelli, Marcello
dc.date.accessioned 2022-10-14T05:21:33Z
dc.date.available 2022-10-14T05:21:33Z
dc.date.issued 2020-07-10
dc.identifier.citation Asif, H., Ahmad, M. I., Alotaibi, N. H., Alharbi, K. S., Bukhari, S. N. A., Saleem, H., & Locatelli, M. (2020). Phytochemical analysis and reappraisal of diuretic activity of Delphinium brunonianum Royle and its mode of action in experimental rats. Pakistan Journal of Pharmaceutical Sciences, 33(4 (Supplementary)), 1833-1838. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13156
dc.description.abstract The aim of this study was the evaluation of diuretic potential of Delphinium brunonianum. Acute diuretic effect in rats was evaluated 8 h after administration of various doses of crude extract, fractions and hydrochlorthiazide. While, prolonged effect of butanolic fraction was assessed after 7days of oral administration in rats. Thereafter, involvement of different pathways in diuretic activity was also appraised. Furthermore, polyphenolic contents in butanolic fraction were assessed using HPLC/UV-VIS technique. All doses of extract and fractions induced a prominent increase in urine and Na+ excretion with no effect on excretion of K+. Prior administration of indomethacin and atropine considerably avoided the diuretic effect of butanolic fraction. Regarding the quantitative chemical analysis the polyphenolic contents were recorded as 28.78 µg/mg. Thus results of present investigation suggested that Delphinium brunonianum possess remarkable diuretic potential. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Delphinium brunonianum en_US
dc.subject diuretic activity en_US
dc.subject prostaglandins en_US
dc.subject muscarinic pathway en_US
dc.subject HPLC/UV-VIS analysis en_US
dc.title Phytochemical analysis and reappraisal of diuretic activity of Delphinium brunonianum Royle and its mode of action in experimental rats en_US
dc.type Article en_US


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