Abstract:
Background: Fibroadenomas are benign breast tumours that are commonly diagnosed in young
woman and are associated with slight increase in the risk of breast cancer. The lesions vary
considerably in their histologic characteristics. Her-2/neu (c-erb-B2) oncogene is a member of
epidermal growth factor receptor family and its amplification is one of the most common genetic
alterations associated with human breast tumours.
Aim: To evaluate any correlation between HER-2 /neu/c-erb B2 immunostaining expression in benign
fibroepithelial lesions - fibroadenoma and its correlation with specific age group.
Methodology: This study was based on the principle that Her-2 / neu antigen is demonstrated using
Avidin –Biotin peroxidase complex method of immunostaining in 25 cases of fibroadenoma.
Results: The results showed that 56% cases took no immunostaining, 28% cases showed faint (+)
level of immunostaining while 16% cases exhibited moderate (++) level of expression. No benign
fibroepithelial lesion manifested intense (+++) level of staining.
Conclusion: The age range in 25 patients of fibroadenoma was 15-38 years with mean age 24.4 +/-
6.59 years. In fibroadenoma group, out of 25 cases, 4 cases (16%) showed a moderate (2+) level of
Her-2 over-expression.
