Abstract:
The objective of this study to evaluate the effect of Resistant Starch (RS) on lipid profile, blood glucose, hormones and TNF-α in Type 2 Diabetes (T2DM). 45 Wister male rats were divided into 5 groups each having 9 rats: without T2DM negative control (NC) with T2DM positive control (PC), resistant starch: 0.20g/kg body weight (HM0.20), resistant starch: 0.30g/kg body weight (HM0.30) and resistant starch: 0.40g/kg body weight (HM0.40). Different levels were added in basal diets while negative and positive control received basal diet. Animals fed on different diets were induced type 2 diabetes 60mg/kg streptozotocin solution injected intraperitoneally in rats. Results of blood glucose showed significantly (P<0.05) lower in all rats fed HM0.20, HM0.30 and HM0.40. In case of lipid profile results indicated that HM0.04 showed significant (P<0.05) increase in HDL level while cholesterol, LDL, triglycerides were reduced. After treatment hormonal profile, leptin, insulin and TNF-α level were significantly (P<0.05) reduced. It may be concluded that RS is the new approach to treat the T2DM.
