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DISPARATE RELATIONSHIP OF VITAMIN D RECEPTOR CDX2 GENE POLYMORPHISM AND POLYCYSTIC OVARIAN SYNDROME

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dc.contributor.author Malik, Soubia
dc.contributor.author Maqsood, Aliya
dc.contributor.author Iqbal, Mehir-un-Nisa
dc.contributor.author Ahmed Khan, Taseer
dc.date.accessioned 2022-10-18T10:18:03Z
dc.date.available 2022-10-18T10:18:03Z
dc.date.issued 2018-12-15
dc.identifier.citation Malik, S., Maqsood, A., & Khan, T. A. (2018). DISPARATE RELATIONSHIP OF VITAMIN D RECEPTOR CDX2 GENE POLYMORPHISM AND POLYCYSTIC OVARIAN SYNDROME IN FEMALES OF SINDH, PAKISTAN. Pakistan Journal of Physiology, 14(4), 18-20. en_US
dc.identifier.issn 1819-270X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13183
dc.description.abstract Vitamin D regulates various biological processes and its role in the pathogenesis of Polycystic Ovarian Syndrome (PCOS) is still dubious. Vitamin D receptor Cdx2 polymorphism is located in the promoter area of Vitamin D receptor gene, its A allele increases and G allele decreases transcription and might play role in the development of insulin resistance in PCOS. The rationale of present study was to investigate the relationship between Vitamin D receptor Cdx2 gene polymorphism and polycystic ovarian Syndrome among young females. Method: A total of 186 subjects (95 cases and 91 controls) were enrolled in this study. Blood samples were collected and genomic DNA was isolated. Genotyping of Vitamin D receptor Cdx2 was carried out using tetra-primer amplification refractory mutation system polymerase chain reaction technique. Results: The genotype frequencies of AA, GA, GG for cases were 8.8%, 12.5%, 78.8% and for controls 11.5%, 15.4%, 73.1% respectively. A non-significant association was observed between Polycystic Ovarian Syndrome (χ 2 :0.707, p=0.702) and Vitamin D receptor Cdx2 gene polymorphism. However, GG (OR: 1.421, 95% CI: 0.293–3.916) and GA (OR: 1.421, 95% CI: 0.497–4.064) genotypes of vitamin D receptor gene polymorphism were at increased risk for PCOS. Conclusion: Vitamin D receptor Cdx2 gene polymorphism may have disparate relationship with PCOS. en_US
dc.language.iso en en_US
dc.publisher Ayub Medical College, Abbottabad. en_US
dc.subject Vitamin D receptor en_US
dc.subject Polycystic Ovarian Syndrome en_US
dc.subject PCOS en_US
dc.subject Cdx2 en_US
dc.subject PCR en_US
dc.subject polymorphism en_US
dc.subject polymerase chain reaction en_US
dc.subject tetra-primer amplification refractory mutation system en_US
dc.title DISPARATE RELATIONSHIP OF VITAMIN D RECEPTOR CDX2 GENE POLYMORPHISM AND POLYCYSTIC OVARIAN SYNDROME en_US
dc.type Article en_US


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