dc.contributor.author |
Malik, Soubia |
|
dc.contributor.author |
Maqsood, Aliya |
|
dc.contributor.author |
Iqbal, Mehir-un-Nisa |
|
dc.contributor.author |
Ahmed Khan, Taseer |
|
dc.date.accessioned |
2022-10-18T10:18:03Z |
|
dc.date.available |
2022-10-18T10:18:03Z |
|
dc.date.issued |
2018-12-15 |
|
dc.identifier.citation |
Malik, S., Maqsood, A., & Khan, T. A. (2018). DISPARATE RELATIONSHIP OF VITAMIN D RECEPTOR CDX2 GENE POLYMORPHISM AND POLYCYSTIC OVARIAN SYNDROME IN FEMALES OF SINDH, PAKISTAN. Pakistan Journal of Physiology, 14(4), 18-20. |
en_US |
dc.identifier.issn |
1819-270X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/13183 |
|
dc.description.abstract |
Vitamin D regulates various biological processes and its role in the pathogenesis of
Polycystic Ovarian Syndrome (PCOS) is still dubious. Vitamin D receptor Cdx2 polymorphism is
located in the promoter area of Vitamin D receptor gene, its A allele increases and G allele decreases
transcription and might play role in the development of insulin resistance in PCOS. The rationale of
present study was to investigate the relationship between Vitamin D receptor Cdx2 gene polymorphism
and polycystic ovarian Syndrome among young females. Method: A total of 186 subjects (95 cases
and 91 controls) were enrolled in this study. Blood samples were collected and genomic DNA was
isolated. Genotyping of Vitamin D receptor Cdx2 was carried out using tetra-primer amplification
refractory mutation system polymerase chain reaction technique. Results: The genotype frequencies of
AA, GA, GG for cases were 8.8%, 12.5%, 78.8% and for controls 11.5%, 15.4%, 73.1% respectively.
A non-significant association was observed between Polycystic Ovarian Syndrome (χ
2
:0.707, p=0.702)
and Vitamin D receptor Cdx2 gene polymorphism. However, GG (OR: 1.421, 95% CI: 0.293–3.916)
and GA (OR: 1.421, 95% CI: 0.497–4.064) genotypes of vitamin D receptor gene polymorphism were
at increased risk for PCOS. Conclusion: Vitamin D receptor Cdx2 gene polymorphism may have
disparate relationship with PCOS. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Ayub Medical College, Abbottabad. |
en_US |
dc.subject |
Vitamin D receptor |
en_US |
dc.subject |
Polycystic Ovarian Syndrome |
en_US |
dc.subject |
PCOS |
en_US |
dc.subject |
Cdx2 |
en_US |
dc.subject |
PCR |
en_US |
dc.subject |
polymorphism |
en_US |
dc.subject |
polymerase chain reaction |
en_US |
dc.subject |
tetra-primer amplification refractory mutation system |
en_US |
dc.title |
DISPARATE RELATIONSHIP OF VITAMIN D RECEPTOR CDX2 GENE POLYMORPHISM AND POLYCYSTIC OVARIAN SYNDROME |
en_US |
dc.type |
Article |
en_US |