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ANTITHROMBIN III LEVEL IN PATIENTS OF β-THALASSEMIA: A CROSS-SECTIONAL STUDY

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dc.contributor.author Bin Saad, Ammar
dc.contributor.author Khan, Javed Iqbal
dc.contributor.author Angez Khan, Tahir
dc.contributor.author Basharat Khan, Muhammad
dc.contributor.author Altaf, Nadia
dc.date.accessioned 2022-10-18T10:38:05Z
dc.date.available 2022-10-18T10:38:05Z
dc.date.issued 2018-12-15
dc.identifier.citation Saad, A. B., Khan, J. I., Khan, T. A., Khan, M. B., & Altaf, N. (2018). ANTITHROMBIN III LEVEL IN PATIENTS OF β-THALASSEMIA: A CROSS-SECTIONAL STUDY. Pakistan Journal of Physiology, 14(4), 40-43. en_US
dc.identifier.issn 1819-270X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/13216
dc.description.abstract Thalassemia is a genetic disorder associated with reduced production rate of either a single or more globin chains in the haemoglobin. Thalassemia is divided into two main types, alpha (α) thalassemia and beta (β) thalassemia. The aim of this study was to determine antithrombin III level in diagnosed patients of beta thalassemia major. Methods: This cross-sectional study was conducted at Sheikh Zayed Hospital Lahore from Jan 2014 to Jan 2015. The sample size was 100 including 50 healthy controls and 50 patients with β thalassemia major. Antithrombin III assay was done with Chromogenic determination of Antithrombin (AT) on an auto analyzer. Results: Mean age splenectomized group was 9.1±2.2 years and that for non-splenectomized and control group was 6.5±2.9. The mean antithrombin III level for the splenectomized group was 66.0±8.9% and that for non-splenectomized and control group was 78.6±9.6 and 91.9±4.7 respectively. The overall mean antithrombin III level for cases was 75.8±10.7. The differences for antithrombin III level were significant (p<0.001). The splenectomized group also had significantly lower antithrombin III level as compared to the non-splenectomized group (p=0.001). Conclusion: Antithrombin III level is significantly affected in thalassemia. A considerable difference was observed in antithrombin III levels of splenectomized and non-splenectomized patients en_US
dc.language.iso en en_US
dc.publisher Ayub Medical College, Abbottabad. en_US
dc.subject Antithrombin en_US
dc.subject Thalassemia en_US
dc.subject Splenectomized en_US
dc.subject Normality en_US
dc.title ANTITHROMBIN III LEVEL IN PATIENTS OF β-THALASSEMIA: A CROSS-SECTIONAL STUDY en_US
dc.type Article en_US


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